The neuron-microglia interaction

The aim of a sub-project within ForInter is to investigate the neuron-microglia interaction in the human brain under healthy and pathological conditions.

Microglial cells play an important role in brain development and neuronal connectivity. Within the project, human microglia-like cells are generated from induced pluripotent stem cells (iPSCs). The interactions in two-dimensional models and three-dimensional tissue assemblies, the organoids, will be investigated. The study will be conducted using iPSCs from patients with familial leukodystrophy with CSF1R mutation, a disease caused by microglia. Genome editing methods will be used to uncover the role of the mutation.