Organoids in cancer research
Patient-derived three-dimensional cell culture systems offer new opportunities to study the interactions of tumor cells in a purely human model.
Conventional glioma cell cultures have limitations, as they do not adequately reflect the tumor cell heterogeneity of glioblastoma. However, the interaction of the different cell types (stem cells and differentiated cells) and the influence of gradients of the microenvironment are of great importance for realistic tumor modeling. The tumor heterogeneity of tumor organoids is being researched in the group. In addition, a pure autologous model system of primary glioma stem cells will be used to gain deeper insights into the interaction of cancer-forming and healthy cell populations in the central nervous system.
