Clinical Research Unit 5024 (GB.Com)

GB.Com Immune checkpoints of gut-brain communication in inflammatory and neurodegenerative diseases

The gut-brain axis, a bidirectional communication system controlled by neural, hormonal, metabolic, immunological, and microbial signals, plays a crucial role in modulating brain function. Recent insights highlight the significance of disrupted gut-brain communication in the pathogenesis of gastrointestinal and neurological disorders. Clinical studies indicate a heightened risk of Parkinson’s disease in patients with inflammatory bowel disease (IBD) and suggest a suspected link between IBD and multiple sclerosis (MS). This association underscores the emergence of the concept of a pathological “gut-brain axis”.

The central aim of this clinical research group KFO 5024 (GB.Com) is to deepen the understanding of interactions along the gut-brain axis in immune-mediated inflammatory and degenerative diseases. By bridging the research focuses of immunology and neuroscience, the group aims to uncover unique insights into the pathogenesis of these conditions, laying the groundwork for the development of new diagnostic and therapeutic targets.

Further information can be found under KFO 5024