Cellular Optomechanics lab – Unveiling the Cell Biology of Immune Cells
Our lab investigates how immune cells coordinate molecular and structural processes to mount efficient immune responses. We focus on the cell biology of dendritic cells, macrophages, and T cells, studying how their migration, signal transduction, cytoskeletal remodeling, and organelle positioning shape their ability to detect, process, and respond to antigens. To uncover these mechanisms, we use a combination of in vitro reconstitution assays, genetically engineered mouse models, and live imaging of immune responses in tissues. These approaches are complemented by genome editing, advanced microscopy, and biophysical tools to quantitatively dissect immune cell behavior in space and time.
By uncovering how immune cells orchestrate their responses at the molecular level, our research provides insights into the mechanisms underlying immune dysfunction in autoimmunity, cancer, and chronic inflammation, and may inform the development of targeted therapies that modulate immune cell behavior for clinical benefit.
For further information please visit Homepage
