Links zu Publikationen 2025

T cell engagers emerge as a compelling therapeutic modality. 

Baeuerle PA, Sauer K, Grieshaber-Bouyer R, Michaelson JS.

J Exp Med. 2026 Feb 2;223(2):e20251652. doi: 10.1084/jem.20251652. Epub 2025 Dec 26.

PMID: 41474966      Review.      

Author Correction: E-type prostanoid receptor 4 drives resolution of intestinal inflammation by blocking epithelial necroptosis. 

Patankar JV, Müller TM, Kantham S, Acera MG, Mascia F, Scheibe K, Mahapatro M, Heichler C, Yu Y, Li W, Ruder B, Günther C, Leppkes M, Mathew MJ, Wirtz S, Neufert C, Kühl AA, Paquette J, Jacobson K, Atreya R, Zundler S, Neurath MF, Young RN, Becker C.

Nat Cell Biol. 2025 Dec 22. doi: 10.1038/s41556-025-01863-y. Online ahead of print.

PMID: 41429937      No abstract available. 

Comparison of long-term efficacy, tolerability and drug survival rates of baricitinib as monotherapy or combination therapy in RA patients: data from a real-world prospective cohort study. 

Temiz A, Tascilar K, Kleyer A, Hueber AJ, Hartmann F, Schett G, Bayat S.

RMD Open. 2025 Dec 17;11(4):e006333. doi: 10.1136/rmdopen-2025-006333.

PMID: 41407433      Free PMC article.      

New insights into Th9 cells in inflammatory bowel diseases. 

Neurath MF.

Semin Immunol. 2025 Dec 16;81:102013. doi: 10.1016/j.smim.2025.102013. Online ahead of print.

PMID: 41406701      Review.      

Characteristics and quality of life of nine-year survivors with metastatic melanoma treated with pembrolizumab beyond second-line therapy. 

Dugas-Breit S, Forschner A, Erdmann M, Gutzmer R, Kähler KC, Holst I, Brekner A, Franklin C, Sindrilaru A, Zimmer L, Heinzerling L, Utikal J, Meier F, Bender A, Berking C, Garbe C, Weichenthal M, Schadendorf D, Hauschild A, Gschnell M, Mohr P, Hassel JC.

Eur J Cancer. 2025 Nov 29;233:116149. doi: 10.1016/j.ejca.2025.116149. Online ahead of print.

PMID: 41385939      

Functional differences between CLL- and ALL-derived CAR T cells in a 3D tumor microenvironment highlight CXCR4 and IL-10 as potential modulatory targets. 

Dingfelder J, Aigner M, Lindacher J, Lukas P, Flamann C, Nusser G, Zimmermann K, Schambach A, Graw F, Völkl S, Bruns H, Krumbholz M, Haibach M, Wilke J, Mackensen A, Lutzny-Geier G.

Hemasphere. 2025 Dec 8;9(12):e70279. doi: 10.1002/hem3.70279. eCollection 2025 Dec.

PMID: 41368078      Free PMC article.      

Membrane Vesicles from Lacticaseibacillus Casei BL23 Exhibit Antimicrobial Activity Against Escherichia coli and Immunostimulatory Effects on Human Peripheral Blood Mononuclear Cells. 

D'Antoni CL, Pourtalebi Jahromi L, Sana L, Domínguez Rubio AP, Dorfner M, Munkert J, Danzer H, Arnold P, Lebedev M, Zanin E, Pérez OE, Fuhrmann G.

Adv Healthc Mater. 2025 Dec 5:e00548. doi: 10.1002/adhm.202500548. Online ahead of print.

PMID: 41351206      

Fcγ-receptor-activation by circulating immune complexes in systemic autoimmune diseases and its reduction by CD19-CAR T-cell therapy. 

Freitag M, Kolb P, Falcone V, Claus M, Schröder P, Andreeva I, Rodon L, Ewald M, Deicher FS, Stütz AN, Distler JHW, Blank N, Grieshaber-Bouyer R, Muñoz LE, Lorenz HM, Schett G, Merkt W.

Rheumatology (Oxford). 2025 Dec 3:keaf627. doi: 10.1093/rheumatology/keaf627. Online ahead of print.

PMID: 41335463      

Rheumatoid factor and anti-citrullinated protein IgA antibodies in the diagnosis, prognosis and monitoring of patients with rheumatoid arthritis. 

Steffen U, Sieghart D, Steiner G.

J Transl Autoimmun. 2025 Nov 12;11:100332. doi: 10.1016/j.jtauto.2025.100332. eCollection 2025 Dec.

PMID: 41333372      Free PMC article.      Review.      

International real-world study of combination immunotherapy sequences in metastatic melanoma. 

Guardamagna M, Lochrin SE, Smithy JW, Postow M, Gaudy-Marqueste C, Malissen N, Monestier S, Sullivan RJ, Czapla JA, Lawless AR, Pires da Silva I, Long GV, Menzies AM, Dimitriou F, Dummer R, Marchi C, Chaurand A, Dalle S, Ascierto PA, Paone M, Facchini BA, Warrier G, Lipson EJ, Erdmann M, Berking C, Archambaud B, Roy S, Routier E, Boutros C, Jamme P, Belkadi-Sadou D, Simon-Tillaux N, Robert C.

J Immunother Cancer. 2025 Nov 28;13(11):e012225. doi: 10.1136/jitc-2025-012225.

PMID: 41314978      Free PMC article.      

Synovial fibroblast activation occurs before the onset of rheumatoid arthritis and influences the risk of developing disease. 

Atzinger A, Tascilar K, Kleyer A, Hueber AJ, Schmidkonz C, Kuwert T, Beck M, Fagni F, Corte G, Ramming A, Schett G, Bayat S.

RMD Open. 2025 Nov 27;11(4):e005775. doi: 10.1136/rmdopen-2025-005775.

PMID: 41314671      Free PMC article.      

GM-CSF and specific type 2 cytokines induce CD103⁺ and CD301b⁺ cell states in cDC1s and cDC2s. 

Amon L, Vurnek D, Seichter A, Tchitashvili G, Kaszubowski T, Mroz M, Debeuf N, Vogler T, Küpper N, Rengarajan KR, Lächele L, Tochoedo NR, Baranska A, Autenrieth SE, Nimmerjahn F, Hildner K, Pfeffer K, Schraml BU, Heger L, Lambrecht BN, Lehmann CHK, Dudziak D.

Cell Rep. 2025 Dec 23;44(12):116589. doi: 10.1016/j.celrep.2025.116589. Epub 2025 Nov 26.

PMID: 41307996      

Special Issue "Molecular Advances in Cancer Immunotherapy". 

Schaft N.

Int J Mol Sci. 2025 Nov 8;26(22):10839. doi: 10.3390/ijms262210839.

PMID: 41303327      Free PMC article.      

P2Y₁₂-Inhibitor Clopidogrel Promotes Collateral Artery Growth in a Murine Hindlimb Model of Arteriogenesis. 

Elbs K, Bobrowski L, Arnholdt C, Kübler M, Götz P, Rohrmoser MR, Merkus D, Lasch M, Deindl E.

Biomedicines. 2025 Nov 16;13(11):2790. doi: 10.3390/biomedicines13112790.

PMID: 41301883      Free PMC article.      

Functional Brain Imaging Reveals Reconstitution of the Central Nervous Itch Network Upon Rifampicin Therapy in Hepatobiliary Pruritus. 

Vetter M, Buchwald T, Dörfler A, Forster C, Kremer AE.

Acta Derm Venereol. 2025 Nov 25;105:adv44350. doi: 10.2340/actadv.v105.44350.

PMID: 41292166      Free PMC article.      No abstract available. 

Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit. 

Bailey DM, Blottner D, Gunga HC, Schneider S, Wotring V, Baatout S, Durante M, Olde Engberink RHG, Goswami N, Heer M, Liphardt AM, Monici M, Pagnini F, Stern C, Stukenborg JB, Weber T, Vico L, White O, van Ombergen A, Choukér A.

NPJ Microgravity. 2025 Nov 20;11(1):82. doi: 10.1038/s41526-025-00537-1.

PMID: 41266377      Free PMC article.      Review.      

Degeneration and Impaired Resilience of Skull Bone and Hematopoietic Bone Marrow. 

Yang Y, Fan Y, Jain S, Ding Z, Liu H, Horenberg AL, Sun H, Killer MS, Chandra A, Dalan R, Chandran M, Yap L, Chen J, Verma NK, Cheung C, Risbud MV, Bozec A, Ramadan K, Cohen-Solal M, Grayson WL, Ramasamy SK, Kusumbe AP.

bioRxiv [Preprint]. 2025 Oct 3:2025.10.02.679940. doi: 10.1101/2025.10.02.679940.

PMID: 41256358      Free PMC article.      Preprint.      

Biofabrication of 3D-printed, pre-cross-linked alginate dialdehyde-gelatin (ADA-GEL) scaffolds for an in vivo metastatic arteriovenous loop tumor model. 

Sandor E, Karimi T, Schmid R, Kulicke Y, Heltmann-Meyer S, Eckert C, Schmidt SK, Röder J, Heppt MV, Boccaccini AR, Horch RE, Boßerhoff AK, Kengelbach-Weigand A, Arkudas A.

Front Bioeng Biotechnol. 2025 Nov 3;13:1657653. doi: 10.3389/fbioe.2025.1657653. eCollection 2025.

PMID: 41255880      Free PMC article.      

Dual targeting of TNF and IL-23 by a bispecific antibody in ulcerative colitis. 

Atreya R, Neurath MF.

Lancet Gastroenterol Hepatol. 2026 Jan;11(1):5-6. doi: 10.1016/S2468-1253(25)00330-9. Epub 2025 Nov 13.

PMID: 41242335      No abstract available. 

Confounding by indication in observational studies investigating glucocorticoid-associated adverse events in patients with rheumatoid arthritis: a systematic literature review including an assessment of E-values. 

Palmowski A, Beenken AE, Pankow A, Oldenkott J, Käding H, Wiebe E, Boyadzhieva Z, Matteson EL, Minopoulou I, Witte T, Simon D, Boers M, Kleyer A, Buttgereit F.

Ann Rheum Dis. 2025 Nov 13:S0003-4967(25)04447-4. doi: 10.1016/j.ard.2025.10.008. Online ahead of print.

PMID: 41238491      No abstract available. 

Linezolid prevents fibroblast activation and ameliorates tissue fibrosis by inhibition of mitochondrial translation. 

Hong X, Xiao Y, Qi H, Zhu S, Filla T, Györfi AH, Li YN, Xu M, Zhi L, Trinh-Minh T, Dees C, Schett G, Distler JHW, Matei AE.

Arthritis Rheumatol. 2025 Nov 14. doi: 10.1002/art.43440. Online ahead of print.

PMID: 41236049      

Assessment of Health-Related Quality of Life in Patients with Active Versus Inactive Adult-Onset Still's Disease: Data from the PRO-AOSD Survey During the COVID-19 Pandemic. 

Blank N, Andreica I, Rech J, Sözen Z, Feist E.

J Clin Med. 2025 Nov 5;14(21):7848. doi: 10.3390/jcm14217848.

PMID: 41227246      Free PMC article.      

Lifestyle medicine in Parkinson's disease. 

Süß P, Regensburger M, Gassner H, Winkler J.

J Neural Transm (Vienna). 2025 Nov 12. doi: 10.1007/s00702-025-03059-y. Online ahead of print.

PMID: 41222709      Review.      

[Management of systemic lupus erythematosus-Including secondary antiphospholipid syndrome, fertility and pregnancy : S3 guidelines of the German Society for Rheumatology and Clinical Immunology and the German Society for Neurology (DGN), German Society for Internal Medicine (DGIM), German Cardiac Society (DGK), Society for Thrombosis and Hemostasis Research (GTH), German Society for Hematology and Medical Oncology (DGHO), German Society for Pediatric and Adolescent Medicine (DGKJ), Society for Pediatric and Adolescent Rheumatology (GKJR), German Society for Nephrology (DGfN), German Society for Pneumology and Ventilation Medicine (DGP), German Rheumatism League National Association, Lupus Erythematosus Self-help Community, German Dermatological Society (DDG). Version: 1.2]. 

Mucke J, Anders HJ, Aringer M, Berlit P, Böltz S, Burchardi FC, Dörner T, Fischer-Betz R, Hoyer BF, Lorenz HM, Meder B, Miesbach W, Reuss-Borst M, Schanze S, Schwarting A, Seeliger B, Specker C, Tenbrock K, Voll RE, Weinmann-Menke J, Witte T, Worm M, Bertsias G, Schneider M.

Z Rheumatol. 2025 Dec;84(Suppl 3):83-111. doi: 10.1007/s00393-025-01687-z. Epub 2025 Nov 6.

PMID: 41196308      Review.      German.      No abstract available. 

Myosin II regulates cellular thermo-adaptability and the efficiency of immune responses. 

Company-Garrido I, Zurita Carpio A, Colomer-Rosell M, Ciraulo B, Molkenbur R, Lanzerstorfer P, Pezzano F, Agazzi C, Hauschild R, Jain S, Jacques JM, Venturini V, Knapp C, Xie Y, Merrin J, Weghuber J, Schaaf M, Quidant R, Kiermaier E, Ortega Arroyo J, Ruprecht V, Wieser S.

Dev Cell. 2025 Nov 4:S1534-5807(25)00636-7. doi: 10.1016/j.devcel.2025.10.006. Online ahead of print.

PMID: 41192429      

CAR T-cell therapy in systemic sclerosis: the next frontier in immune modulation.  

Garantziotis P, Auth J, Schett G, Bergmann C.

Curr Opin Rheumatol. 2026 Jan 1;38(1):60-68. doi: 10.1097/BOR.0000000000001133. Epub 2025 Oct 30.

PMID: 41185148      Review.      

Checkpoint Blockade Efficacy in Uveal Melanoma Is Linked to Tumor Immunity, CD28, and CCL8. 

Koch EAT, Liguori R, Castro AA, Schliep S, Petzold A, Wessely A, Fröhlich W, Ferrazzi F, Vera J, Eckstein M, Berking C, Heppt MV.

Int J Mol Sci. 2025 Oct 13;26(20):9964. doi: 10.3390/ijms26209964.

PMID: 41155258      Free PMC article.      

Dietary ω-3 polyunsaturated fatty acids (PUFAs) reduce cholesterol-driven non-small cell lung cancer (NSCLC) progression in mouse models of disease. 

Harre P, Hohenberger K, Krammer S, Yang Z, Tausche P, Willar J, Trufa DI, Chiriac MT, Geppert CI, Rauh M, Hildner K, Hartmann A, Sirbu H, Finotto S.

Commun Med (Lond). 2025 Oct 23;5(1):432. doi: 10.1038/s43856-025-01193-y.

PMID: 41131338      Free PMC article.      

Pemphigus Foliaceous With Secondary Herpes Simplex Infection. 

Koch EAT, Sticherling M, Wagner N.

JAMA Dermatol. 2025 Dec 1;161(12):1275-1276. doi: 10.1001/jamadermatol.2025.3578.

PMID: 41123937      

The transcription factor Blimp-1 is suppressed by SLAMF1 and drives Treg cell-mediated immune evasion in non-small cell lung cancer. 

Finotto S, Trufa DI, Trump S, Neurath L, Hohenberger K, Tausche P, Neurath N, Tsiumpala S, Mittler S, Wild A, Nendel E, Sirbu H, Hartmann A.

BJC Rep. 2025 Oct 21;3(1):74. doi: 10.1038/s44276-025-00184-9.

PMID: 41120672      Free PMC article.      

The microbial metabolite desaminotyrosine protects against graft-versus-host disease via mTORC1 and STING-dependent intestinal regeneration. 

Göttert S, Thiele Orberg E, Fan K, Heinrich P, Matthe DM, Khalid O, Klostermeier L, Suriano C, Strieder N, Gebhard C, Vonbrunn E, Mamilos A, Hirsch D, Meedt E, Kleigrewe K, Hiergeist A, Schwarz A, Gläsner J, Ghimire S, Joachim L, Voll F, Neuhaus K, Janssen KP, Perl M, Pielmeier F, Ruland J, Kreutz M, Weber D, Schmidl C, Köhler N, Tschurtschenthaler M, Hoffmann P, Edinger M, Wolff D, Bassermann F, Rehli M, Haller D, Evert M, Hildner K, Büttner-Herold M, Herr W, Gessner A, Heidegger S, Holler E, Poeck H.

Nat Commun. 2025 Oct 20;16(1):9282. doi: 10.1038/s41467-025-65180-6.

PMID: 41115965      Free PMC article.      

Entheseal tissue signature in response to IL-17A inhibition in psoriatic arthritis: results from the EBIO entheseal biopsy study. 

Raimondo MG, Mohammadian H, Rauber S, Alivernini S, Fedorchenko V, Rigau AR, Angeli MR, Fagni F, Corte G, Tascilar K, Labinsky H, Ramming AM, Roemer F, Rech J, Braeuer L, D'Agostino MA, Schett G, Pachowsky M, Kleyer A, Ramming A.

Ann Rheum Dis. 2025 Oct 16:S0003-4967(25)04372-9. doi: 10.1016/j.ard.2025.08.032. Online ahead of print.

PMID: 41107119      

Evaluating the Divide Between Patients' and Physicians' Perceptions of Adult-Onset Still's Disease Cases: Insights from the PRO-AOSD Survey. 

Blank N, Andreica I, Rech J, Sözen Z, Feist E.

J Clin Med. 2025 Oct 4;14(19):7034. doi: 10.3390/jcm14197034.

PMID: 41096115      Free PMC article.      

Predicting treatment outcomes in patients with psoriatic arthritis or axial spondyloarthritis: An artificial intelligence-driven approach. 

Vodenčarević A, Brandt-Jürgens J, Bär S, Kästner P, Köhm M, Simon D, Behrens F, Glassen T, Gmeiner B, Peterlik D, Kiltz U.

J Rheumatol. 2025 Oct 15:jrheum.2025-0327. doi: 10.3899/jrheum.2025-0327. Online ahead of print.

PMID: 41093647      

Comparative profiling of T cell and macrophage subsets in cutaneous squamous cell carcinoma and basal cell carcinoma. 

Winter L, Ries J, Vogl C, Trumet L, Geppert CI, Scholtysek C, Olmos M, Kesting M, Weber M.

Sci Rep. 2025 Oct 9;15(1):35240. doi: 10.1038/s41598-025-22486-1.

PMID: 41068337      Free PMC article.      

Vaccination-induced T cell responses maintain polyclonality with high antigen receptor avidity. 

Kocher K, Drost F, Tesfaye AM, Moosmann C, Schülein C, Grotz M, D'Ippolito E, Graw F, Spriewald B, Busch DH, Bogdan C, Tenbusch M, Schubert B, Schober K.

Sci Immunol. 2025 Oct 3;10(112):eadu6730. doi: 10.1126/sciimmunol.adu6730. Epub 2025 Oct 3.

PMID: 41042909      

Deciphering brain organoid heterogeneity by identifying key quality determinants. 

Boerstler T, Kachkin D, Gerasimova E, Zagha N, Furlanetto F, Nayebzade N, Zappia L, Boisvert M, Farrell M, Ploetz S, Prots I, Regensburger M, Günther C, Winkler J, Gupta P, Theis F, Karow M, Falk S, Winner B, Krach F.

Commun Biol. 2025 Oct 1;8(1):1412. doi: 10.1038/s42003-025-08855-6.

PMID: 41034331      Free PMC article.      

GRAPPA 2024 Meeting: Advances in Psoriatic Disease Research From Pilot Grant Awardees. 

Colaco K, Alzayat O, Dang S, Gross C, Helliwell PS, Karmacharya P, Simon D, Svedbom A, Chandran V, Liao W, de Vlam K.

J Rheumatol. 2025 Dec 1;52(Suppl 3):98-105. doi: 10.3899/jrheum.2025-0876.

PMID: 41033829      

Systemic lupus erythematosus damage risk index (SLE-DRI): a simple machine learning-based tool for identifying patients at risk for early organ damage. 

Garantziotis P, Nikolopoulos D, Katechis S, Temiz A, Nöthling DM, Adamichou C, Bergmann C, Sidiropoulos P, Schett G, Fanouriakis A, Boumpas DT, Bertsias G.

RMD Open. 2025 Sep 30;11(3):e006009. doi: 10.1136/rmdopen-2025-006009.

PMID: 41033712      Free PMC article.      

Response to 'Comment on "Efficacy of interventions for Bowen's disease"'. 

Petzold A, Heppt MV.

J Eur Acad Dermatol Venereol. 2025 Oct 1. doi: 10.1111/jdv.70076. Online ahead of print.

PMID: 41031419      No abstract available. 

CD163/CD63+ Monocyte-Derived DC Profiled in Tissue by Multi-Antigen Analysis (MAA) Discriminate Chronic Eczema and Psoriasis. 

Windorfer S, Kirr M, Fröhlich W, Plosnita B, Ostalecki C, Berking C, Sticherling M, Baur AS.

Int J Mol Sci. 2025 Sep 18;26(18):9077. doi: 10.3390/ijms26189077.

PMID: 41009640      Free PMC article.      

STINGing Cancer: Development, Clinical Application, and Targeted Delivery of STING Agonists. 

Nerdinger YG, Binder AK, Bremm F, Feuchter N, Schaft N, Dörrie J.

Int J Mol Sci. 2025 Sep 16;26(18):9008. doi: 10.3390/ijms26189008.

PMID: 41009575      Free PMC article.      Review.      

An artificial intelligence model of whole-slide pathology specimens differentiating cutaneous high-grade squamous proliferations. 

Petzold A, Wessely A, Erdmann M, Schliep S, Schreml S, Rivera Monroy LC, Vera J, Drexler K, Niebel D, Hayani KM, Kiesewetter F, Berking C, Koch EAT, Heppt MV.

Virchows Arch. 2025 Nov;487(5):1047-1058. doi: 10.1007/s00428-025-04272-6. Epub 2025 Sep 25.

PMID: 40999035      Free PMC article.      

Maintenance Treatment for Type 1 Autoimmune Pancreatitis: Effectiveness and Development of the PrescrAIP Relapse Prediction Model. 

Lanzillotta M, Macinga P, Poulsen JL, Vinge-Holmquist O, Demirci AF, Tacelli M, Backhus J, Algül H, Descourvieres C, Kiriukova M, Goni E, Hollenbach M, Miksch RC, Kunovsky L, Vujasinovic M, Nikolic S, Dickerson L, Hirth M, Neurath MF, Zumblick M, Vila J, Jalal M, Beyer G, Frost F, Carrara S, Kala Z, Jabandziev P, Sisman G, Akyuz F, Capurso G, Falconi M, Arlt A, Vleggaar FP, Barresi L, Greenhalf B, Czakó L, Hegyi P, Hopper A, Nayar MK, Gress TM, Vitali F, Schneider A, Halloran CM, Trna J, Okhlobystin AV, Dagna L, Cahen DL, Bordin D, Rebours V, Mayerle J, Kahraman A, Rasch S, Culver E, Kleger A, Martínez-Moneo E, Hucl T, Olesen SS, Bruno MJ, Beuers U, Della-Torre E, Löhr JM, Rosendahl J, Overbeek KA; PrescrAIP Study Group.

Clin Gastroenterol Hepatol. 2025 Sep 13:S1542-3565(25)00795-5. doi: 10.1016/j.cgh.2025.09.005. Online ahead of print.

PMID: 40953780      

Neurotrophic factors in multiple sclerosis. 

Güner F, Rothhammer V.

Front Immunol. 2025 Aug 27;16:1654603. doi: 10.3389/fimmu.2025.1654603. eCollection 2025.

PMID: 40936917      Free PMC article.      Review.      

Uncovering the evolving arms race between host immunity and HIV-1. 

Song YH, Kim H, Baur AS, Lee JH.

Trends Immunol. 2025 Nov;46(11):728-740. doi: 10.1016/j.it.2025.08.004. Epub 2025 Sep 10.

PMID: 40930905      Review.      

Real-world management and outcomes of immune-related adverse events in German cancer care: A multicenter analysis using the SERIO registry. 

Ertl C, Tomsitz D, Rizzo F, Hempel D, Heinzerling L, Milani V.

Oncologist. 2025 Oct 1;30(10):oyaf275. doi: 10.1093/oncolo/oyaf275.

PMID: 40929088      Free PMC article.      

4-Octyl Itaconate ameliorates diesel exhaust particle-induced oxidative stress in nasal epithelial cells. 

Steppuhn H, Hohenberger K, Mittler S, Trump S, Carvalho C, Rauh M, Wild AB, Papadopoulos NG, Finotto S.

Front Immunol. 2025 Aug 22;16:1640499. doi: 10.3389/fimmu.2025.1640499. eCollection 2025.

PMID: 40918100      Free PMC article.      

[Long-term follow up of efficiency and safety of CD19-CAR T-cell treatment of systemic lupus erythematosus]. 

Taubmann J, Böltz S, Hagen M, Wirsching A, Müller F, Völkl S, Kharboutli S, Spörl S, Garantziotis P, Aigner M, Grieshaber-Bouyer R, Mackensen A, Schett G.

Z Rheumatol. 2025 Oct;84(8):612-620. doi: 10.1007/s00393-025-01705-0. Epub 2025 Sep 4.

PMID: 40906188      Free PMC article.      Clinical Trial.      German.      

PU.1 upregulation is linked to improved prognosis in non-small cell lung cancer. 

Hohenberger K, Trufa DI, Hartmann A, Mittler S, Trump S, Sirbu H, Finotto S.

Front Immunol. 2025 Aug 15;16:1604237. doi: 10.3389/fimmu.2025.1604237. eCollection 2025.

PMID: 40895524      Free PMC article.      

[Experiences after CD19-CAR T-cell therapy in non-SLE connective tissue diseases]. 

Merkt W, Henes J, Bergmann C, Lorenz HM.

Z Rheumatol. 2025 Oct;84(8):621-631. doi: 10.1007/s00393-025-01700-5. Epub 2025 Sep 1.

PMID: 40888840      Review.      German.      

High-Intensity Interval Training as Redox Medicine: Targeting Oxidative Stress and Antioxidant Adaptations in Cardiometabolic Disease Cohorts. 

Reljic D.

Antioxidants (Basel). 2025 Jul 30;14(8):937. doi: 10.3390/antiox14080937.

PMID: 40867832      Free PMC article.      Review.      

[Amniotic membrane-covered bioimplants for treatment of severe pseudomembranous keratoconjunctivitis in two patients with erythema exsudativum multiforme following pneumonia caused by Mycoplasma pneumoniae]. 

Voulgari T, Heppt MV, Steinhorst K, Kruse FE, Weller JM.

Ophthalmologie. 2025 Aug 29. doi: 10.1007/s00347-025-02317-4. Online ahead of print.

PMID: 40879749      German.      No abstract available. 

CytoNormPy Enables a Fast and Scalable Removal of Batch Effects in Cytometry Datasets. 

Exner T, Hackert N, Leomazzi L, Van Gassen S, Saeys Y, Lorenz HM, Grieshaber-Bouyer R.

Cytometry A. 2025 Sep;107(9):629-635. doi: 10.1002/cyto.a.24953. Epub 2025 Aug 29.

PMID: 40879360      

Bottom-up Investigation of Spatiotemporal Glycocalyx Dynamics with Interferometric Scattering Microscopy. 

Brunner CM, Pietsch L, Vom Sondern I, Röhrl M, Popov C, Trollmann MFW, Taylor RW, Blessing M, Holler C, Almahayni K, Jaeschke SO, Sandoghdar V, Böckmann RA, Lindhorst TK, Möckl L.

J Am Chem Soc. 2025 Sep 10;147(36):32799-32808. doi: 10.1021/jacs.5c08659. Epub 2025 Aug 27.

PMID: 40865950      

Local immune effector cell-associated toxicity syndrome in CAR T-cell treated patients with refractory systemic lupus erythematosus - Authors' reply. 

Hagen M, Müller F, Wirsching A, Kharboutli S, Spoerl S, Düsing C, Krickau T, Metzler M, Völkl S, Aigner M, Kretschmann S, Vasova I, Saake M, Schliep S, Kubacki T, Hunzelmann N, Bucci L, Taubmann J, Bergmann C, Györfi AH, Dietrich S, Distler JHW, Grieshaber-Bouyer R, Mackensen A, Schett G.

Lancet Rheumatol. 2025 Oct;7(10):e667-e669. doi: 10.1016/S2665-9913(25)00222-X. Epub 2025 Aug 12.

PMID: 40816306      No abstract available. 

Safety, tolerability, pharmacokinetics, and pharmacodynamic effects of desmoglein 3-peptide-coupled tolerizing nanoparticles in pemphigus. 

Didona D, Hudemann C, Garn H, Krzikalla D, Wang SH, Hinterseher J, Volkmann K, Polakova A, Zakrzewicz A, Feldhoff S, Tikkanen R, Digigow R, Pfützner W, Santos A, Zimmer CL, Hahmann M, Harnisch S, Rösch S, Huguenin S, Eming R, Hahn M, Schauer F, Antiga E, Senatore S, Maglie R, Täubel J, Ghoreschi K, Meier K, Solimani F, Sticherling M, Sollfrank L, Günther C, Steinbrink K, Magnolo N, van Schaick E, Asnaghi V, Zollmann FS, Pohlner J, Hummel J, Sandbrink R, de Min C, Fleischer S, Möbs C, Hertl M.

Br J Dermatol. 2025 Aug 7:ljaf311. doi: 10.1093/bjd/ljaf311. Online ahead of print.

PMID: 40795222      

Case Report: Personalized peptide-based immunization in an advanced-stage prostate cancer patient with bone metastasis. 

Thoennissen NH, Martos-Contreras MC, Manoochehri M, Nogueira M, Bremm F, Dörrie J, Christoph J, Kunz M, Schönharting W.

Front Oncol. 2025 Jul 22;15:1596315. doi: 10.3389/fonc.2025.1596315. eCollection 2025.

PMID: 40766334      Free PMC article.      

Serum Levels of Aryl Hydrocarbon Receptor Plasma Agonist Activity Are Reduced in Patients With NMOSD and Correlate With Disease Activity. 

Tsaktanis T, Ammon L, Lößlein L, Peter A, Vandrey O, Naumann UJ, Behne M, Cook LJ, Levy M, Yeaman MR, Bennett JL, Rothhammer V; Guthy-Jackson Charitable Foundation CIRCLES Study Group.

Neurol Neuroimmunol Neuroinflamm. 2025 Sep;12(5):e200457. doi: 10.1212/NXI.0000000000200457. Epub 2025 Aug 5.

PMID: 40763318      Free PMC article.      

Neutrophil Heterogeneity Identifies an Association of LAMP1 With Proliferative Lupus Nephritis. 

Ostendorf L, Garantziotis P, Huang FY, Schett G; Accelerating Medicines Partnership: RA/SLE Network; Lederer JA, Fava A, Rao DA, Grieshaber-Bouyer R.

Eur J Immunol. 2025 Aug;55(8):e70022. doi: 10.1002/eji.70022.

PMID: 40760840      Free PMC article.      

Repurposed clindamycin suppresses pyroptosis in tumor-associated macrophages through Inhibition of caspase-1. 

Weich A, Berges J, Flamann C, Bitterer K, Singh KP, Chambers D, Lischer C, Lai X, Wolkenhauer O, Berking C, Krönke G, Gupta S, Bruns H, Vera J, Macrophages RG.

J Exp Clin Cancer Res. 2025 Aug 4;44(1):225. doi: 10.1186/s13046-025-03478-5.

PMID: 40759978      Free PMC article.      

Gene expression and molecular pathway analyses differentiate immunotherapy-induced myositis from spontaneous dermatomyositis. 

Röckel M, Musella L, Preusse C, Radke J, Zimmer L, Thoms KM, Dimitriou F, Endres M, Böhmerle W, Fröhlich W, Tayb-Boulahfa S, Leonard-Louis S, Allenbach Y, Berking C, Stenzel W, Knauss S, Vera J, Heinzerling L.

Sci Rep. 2025 Aug 4;15(1):28434. doi: 10.1038/s41598-025-11944-5.

PMID: 40759686      Free PMC article.      

A multidimensional analysis of temporomandibular joint and ankle joint erosion in inflammatory arthritis. 

Andreev D, Porschitz P, Weidner D, Song R, Weider M, Schett G, Gölz L, Bozec A.

Front Immunol. 2025 Jul 18;16:1560723. doi: 10.3389/fimmu.2025.1560723. eCollection 2025.

PMID: 40755771      Free PMC article.      

Intermittent preventive treatment, malaria, HIV, hepatitis and pregnancy outcomes in Nigerian women: a cross-sectional study in two healthcare facilities. 

Chukwuanukwu RC, Eleje GU, Menkiti FE, Ikpeze GC, Mbachu CN, Obiegbu NP, Ogbomade CC, Anyaegbu HI, Ehiaghe AF, Ezeagwuna DA, Efobi CC, Egwuatu EC, Orjinta KK, James JE, Agbanu CM, Onubuogu CU, Ezenwa OB, Okafor CD, Onah KS, Chukwuanukwu TO.

BMC Pregnancy Childbirth. 2025 Aug 2;25(1):809. doi: 10.1186/s12884-025-07943-z.

PMID: 40753415      Free PMC article.      

Safety, tolerability and clinical effects of rovunaptabin, also known as BC007 on fatigue and quality of life in patients with Post-COVID syndrome (reCOVer): a prospective, exploratory, placebo-controlled, double-blind, randomised phase IIa clinical trial (RCT). 

Hohberger B, Ganslmayer M, Harrer T, Kruse F, Maas S, Borst T, Heimke-Brinck R, Stog A, Knauer T, Rühl E, Zeisberg V, Skornia A, Bartsch A, Ströbel A, Wytopil M, Merkel C, Hofmann S, Schmidt KG, Lakatos P, Schottenhamml J, Herrmann M, Mardin C, Rech J.

EClinicalMedicine. 2025 Jul 22;86:103358. doi: 10.1016/j.eclinm.2025.103358. eCollection 2025 Aug.

PMID: 40735347      Free PMC article.      

Investigation of the CTLA-4-CD28 Axis in Oral Squamous Cell Carcinoma. 

Feldmeier F, Weber M, Pacelli F, Vogl C, Glajzer J, Trumet L, Buchbender M, Geppert C, Kesting M, Ries J.

J Clin Med. 2025 Jul 21;14(14):5171. doi: 10.3390/jcm14145171.

PMID: 40725864      Free PMC article.      

Functional Autoantibodies Targeting G-Protein-Coupled Receptors and Their Clinical Phenotype in Patients with Long-COVID. 

Hofmann S, Lucio M, Wallukat G, Hoffmanns J, Schröder T, Raith F, Szewczykowski C, Skornia A, Rech J, Schottenhamml J, Harrer T, Ganslmayer M, Mardin C, Flecks M, Lakatos P, Hohberger B.

Int J Mol Sci. 2025 Jul 14;26(14):6746. doi: 10.3390/ijms26146746.

PMID: 40724994      Free PMC article.      

Chimeric antigen receptor T cells in treatment-refractory DAGLA antibody-associated encephalitis. 

Hegelmaier T, Wolleschak D, Pappa V, Wickel J, Geis C, Miske R, Duscha A, Desel C, Böttcher M, Neyazi A, Faissner S, Motte J, Gold R, Borie D, Schett G, Mougiakakos D, Haghikia A.

Med. 2025 Sep 12;6(9):100776. doi: 10.1016/j.medj.2025.100776. Epub 2025 Jul 23.

PMID: 40706586      

Differential molecular signatures in response to CD19-CAR T cell therapy compared with conventional pharmacotherapy in systemic lupus erythematosus. 

Garantziotis P, Beretta L, Lindblom J, Moysidou GS, Nikolopoulos D, Grieshaber-Bouyer R, Hagen M, Bergmann C, Wirsching A, Bozec A; PRECISESADS Clinical Consortium; Schneider M, Barturen G, Bertsias G, Boumpas DT, Alarcón-Riquelme ME, Mackensen A, Schett G, Parodis I.

Ann Rheum Dis. 2025 Jul 22:S0003-4967(25)04187-1. doi: 10.1016/j.ard.2025.06.2132. Online ahead of print.

PMID: 40701862      

Enhanced diagnostic potential of CSPG4 in melanoma and nevi: a comparative study with PRAME, CDC7 and Ki67. 

Koch EAT, Seidel C, Erber R, Erdmann M, Heppt MV, Schliep S, Berking C, Dörrie J, Schaft N.

J Pathol. 2025 Sep;267(1):69-78. doi: 10.1002/path.6450. Epub 2025 Jul 23.

PMID: 40700516      Free PMC article.      

Primary and secondary metastatic dissemination: multiple routes to cancer-related death. 

Sparrer D, Blazquez R, Keil F, Einhell S, Lüke F, Uderhardt S, Gerner C, Wendl CHR, Proescholdt M, Schulz C, Kandulski A, Haferkamp S, Schlitt HJ, Bäuerle T, Franze K, Mayr R, Rechenmacher M, Hau P, Hirsch D, Heudobler D, Evert K, Pukrop T.

Mol Cancer. 2025 Jul 22;24(1):203. doi: 10.1186/s12943-025-02389-5.

PMID: 40696378      Free PMC article.      Review.      

Bioengineered Bacterial Vesicles and Biomimetic Hybrids Eliminate Biofilms and Balance the Gut Microbiome. 

Pourtalebi Jahromi L, Kronast B, Munkert J, Sana L, Koch M, Danzer H, Dormeyer S, Jiang S, Herrmann F, Weiler M, Kashkanova A, Sandoghdar V, Zaiss MM, Fuhrmann G.

Small. 2025 Jul 22:e2502551. doi: 10.1002/smll.202502551. Online ahead of print.

PMID: 40693324      

Calibration-free Laser-induced Breakdown Spectroscopy (CF-LIBS): Plasma criteria for porcine tissue. 

Böhmer E, Degelmann LS, Thoma OM, Waldner MJ, Mehari F, Klämpfl F, Hohmann M, Schmidt M.

Talanta. 2026 Jan 1;297(Pt A):128545. doi: 10.1016/j.talanta.2025.128545. Epub 2025 Jul 15.

PMID: 40680366      

Neutrophils aggravate inflammatory lesions in intestinal organoids from necrotizing enterocolitis. 

Heuer KM, Boettcher M, Raluy LP, Hagens J, Kolman JP, Bunders MJ, Wesche J, Knopf J, Herrmann M, Reinshagen K, Vincent D.

Front Immunol. 2025 Jun 27;16:1582526. doi: 10.3389/fimmu.2025.1582526. eCollection 2025.

PMID: 40655144      Free PMC article.      

Effects of different B-cell-depleting strategies on the lymphatic tissue. 

Tur C, Eckstein M, Bucci L, Auth J, Bergmann C, Rauber S, Hagen M, Nöthling DM, Böltz S, Wirsching A, Tascilar K, Fagni F, Corte G, Rius Rigau A, Qin Y, Garantziotis P, Taubmann J, Wacker J, Ramming A, D Agostino MA, Rauch S, Hartmann A, Müller F, Mackensen A, Grieshaber-Bouyer R, Schett G, Bozec A, Raimondo MG.

Ann Rheum Dis. 2025 Dec;84(12):2065-2074. doi: 10.1016/j.ard.2025.06.2120. Epub 2025 Jul 11.

PMID: 40651933      

Rendering NK Cells Antigen-Specific for the Therapy of Solid Tumours. 

Doeppner CA, Binder AK, Bremm F, Feuchter N, Dörrie J, Schaft N.

Int J Mol Sci. 2025 Jun 29;26(13):6290. doi: 10.3390/ijms26136290.

PMID: 40650066      Free PMC article.      Review.      

Gut-specific histamine 3 receptor signaling orchestrates microglia-dependent resolution of peripheral inflammation. 

Dürholz K, Ehnes L, Linnerbauer M, Schmid E, Danzer H, Hinzpeter-Schmidt M, Lößlein L, Amend L, Frech M, Azizov V, Schälter F, Gessner A, Lucas S, Lesker TR, Taudte RV, Hofmann J, Beyer F, Bootz-Maoz H, Reich Y, Romano H, Mauro D, Beckervordersandforth R, Kragsnaes MS, Ellingsen T, Xiang W, Haghikia A, Akdis CA, Ciccia F, Bäuerle T, Sarter K, Strowig T, Yissachar N, Schett G, Rothhammer V, Zaiss MM.

J Clin Invest. 2025 Jul 10;135(18):e184697. doi: 10.1172/JCI184697. eCollection 2025 Sep 16.

PMID: 40638239      Free PMC article.      

The Biology of Dendritic Cells: In Health and Disease. 

Royzman D, Dörrie J, Heiß A, Sinner P, Peckert-Maier K, Schaft N, Sadeghi Shermeh A, Strack A, Wild A, Steinkasserer A.

Adv Exp Med Biol. 2025;1476:1-30. doi: 10.1007/978-3-031-85340-1_1.

PMID: 40622537      Review.      

Spatially informed phenotyping by cyclic-in-situ-hybridisation identifies novel fibroblast populations and their pathogenic niches in systemic sclerosis. 

Li YN, Filla T, Györfi AH, Liang M, Devakumar V, Micu A, Chai H, Bergmann C, Pecher AC, Henes J, Moinzadeh P, Al-Gburi S, Krieg T, Kreuter A, Wang J, Schett G, Homey B, Dietrich S, Distler JHW, Matei AE.

Ann Rheum Dis. 2025 Nov;84(11):1852-1864. doi: 10.1016/j.ard.2025.06.002. Epub 2025 Jul 1.

PMID: 40603206      

Macrophages foster anti-tumor immunity by ZEB1-dependent cytotoxic T cell chemoattraction. 

Fuchs K, D'Avanzo E, Armstark I, van Roey R, Clavel Ezquerra A, Bindel N, Siebenkäs K, Hajjaj Y, Liguori R, Ferrazzi F, Amon L, Bulang J, Hübner J, Edler M, Grace E, Schwab A, Alfredo M, Faas M, Ackermann J, Percivalle E, Günther C, Hoffmann MH, Krönke G, Becker C, Dudziak D, Arnold P, Woehner M, Nimmerjahn F, Brabletz S, Stemmler MP, Brabletz T, Schuhwerk H.

Commun Biol. 2025 Jul 1;8(1):976. doi: 10.1038/s42003-025-08339-7.

PMID: 40595293      Free PMC article.      

[CAR T cells in non-malignant diseases]. 

Müller F, Hagen M, Schett G, Mackensen A.

Inn Med (Heidelb). 2025 Aug;66(8):810-817. doi: 10.1007/s00108-025-01945-x. Epub 2025 Jun 30.

PMID: 40586812      Review.      German.      

Matrix stiffness regulates profibrotic fibroblast differentiation and fibrotic niche activation in systemic sclerosis. 

Ueberall L, Mohammadian H, Demmler R, Ariza Y, Tripal P, Anchang CG, Weber S, Angeli MR, Raimondo MG, Chang J, Huang K, Distler JHW, Distler O, Rauber S, Schett G, Ramming A, Ramming AM.

Ann Rheum Dis. 2025 Nov;84(11):1865-1876. doi: 10.1016/j.ard.2025.05.016. Epub 2025 Jun 26.

PMID: 40579317      

[Pharmacological inhibition of fibrosis exemplified by systemic sclerosis : Possibilities and limits]. 

Dashi T, Bergmann C.

Inn Med (Heidelb). 2025 Jul;66(7):702-711. doi: 10.1007/s00108-025-01925-1. Epub 2025 Jun 27.

PMID: 40576794      German.      

Novel aryl hydrocarbon receptor agonists as potential anti-inflammatory therapeutics: Identification and validation through drug repurposing. 

Haupt J, Keminer O, Neser C, Windshügel B, Wiltzsch V, Schmidt JR, Pliushcheuskaya P, Künze G, Scholz U, Müller C, Oliveira da Rocha GH, Biermann MK, Zdzieblo D, Metzger M, Schiefke I, Neurath MF, Siegmund B, Claussen C, Köhl U, Geisslinger G, Buchholz M, Kalkhof S, Lehmann J.

Biochem Pharmacol. 2025 Oct;240:117066. doi: 10.1016/j.bcp.2025.117066. Epub 2025 Jun 24.

PMID: 40571216      

Chimeric Antigen Receptor (CAR) T Cells Releasing Soluble SLAMF6 Isoform 2 Gain Superior Anti-Cancer Cell Functionality in an Auto-Stimulatory Fashion. 

Harrer DC, Schlierkamp-Voosen T, Barden M, Pan H, Xydia M, Herr W, Dörrie J, Schaft N, Abken H.

Cells. 2025 Jun 14;14(12):901. doi: 10.3390/cells14120901.

PMID: 40558528      Free PMC article.      

Corrigendum: Advancement and independent validation of a deep learning-based tool for automated scoring of nail psoriasis severity using the modified nail psoriasis severity index. 

Kemenes S, Chang L, Schlereth M, Noversa de Sousa R, Minopoulou I, Fenzl P, Corte G, Yalcin Mutlu M, Höner MW, Sagonas I, Coppers B, Liphardt AM, Simon D, Kleyer A, Folle L, Sticherling M, Schett G, Maier A, Fagni F.

Front Med (Lausanne). 2025 Jun 5;12:1617441. doi: 10.3389/fmed.2025.1617441. eCollection 2025.

PMID: 40538405      Free PMC article.      

Pharmacological inhibitors of the gamma-secretase enzyme complex disrupt epithelial cell function triggering colitis in mice. 

Erkert L, Kabisch M, Gamez-Belmonte R, Gonzalez-Acera M, Patankar JV, Schödel L, Hofmann K, Wagner Y, Plattner C, Spath EM, Distler U, Tenzer S; TRR241 IBDome Consortium; Neufert C, Neurath MF, Becker C.

J Crohns Colitis. 2025 Jul 3;19(7):jjaf096. doi: 10.1093/ecco-jcc/jjaf096.

PMID: 40503970      

ST6GAL1 promotes IBD B cell recruitment to the inflamed colon in a CD22-dependent mechanism. 

Liu LJ, Müller TM, Dedden M, Schramm S, Leppkes M, Atreya R, Atreya I; TRR241 IBDome consortium; Neurath MF, Zundler S.

J Crohns Colitis. 2025 Jul 3;19(7):jjaf097. doi: 10.1093/ecco-jcc/jjaf097.

PMID: 40491026      

Decoding diabetic kidney disease: a comprehensive review of interconnected pathways, molecular mediators, and therapeutic insights. 

Efiong EE, Maedler K, Effa E, Osuagwu UL, Peters E, Ikebiuro JO, Soremekun C, Ihediwa U, Niu J, Fuchs M, Bazireh H, Bassey AL, Amadi PU, Dong Q, Kimani NM, Chukwuanukwu RC, Tuenter E, Sharma S, Grallert H.

Diabetol Metab Syndr. 2025 Jun 4;17(1):192. doi: 10.1186/s13098-025-01726-4.

PMID: 40468401      Free PMC article.      Review.      

Long-Term Follow-Up of Real-World Adjuvant Anti-PD-1 Checkpoint Inhibition and Targeted Therapy in Patients With Stage III Melanoma. 

Lodde GC, Hassel JC, von Wasielewski I, Meier F, Mohr P, Kähler K, Hauschild A, Glutsch V, Stege H, Berking C, Hüning S, Huynh J, Gutzmer R, Reinhardt L, Schilling B, Loquai C, Erdmann M, Stang A, Kowall B, Galetzka W, Roesch A, Tilkorn D, Ugurel S, Zimmer L, Schadendorf D, Forschner A, Livingstone E.

J Clin Oncol. 2025 Sep;43(25):2793-2805. doi: 10.1200/JCO-24-02776. Epub 2025 Jun 3.

PMID: 40460331      

Advances in precision medicine in imaging and therapeutic strategies for psoriatic disease. 

Witte T, Minopoulou I, Drzeniek NM, Torgutalp M, Sabat R, Casteleyn V, Albach F, Fagni F, Schett G, Zabotti A, Krönke G, McGonagle D, Köhm M, Behrens F, Kleyer A, Simon D.

Autoimmun Rev. 2025 Jul 31;24(8):103839. doi: 10.1016/j.autrev.2025.103839. Epub 2025 May 31.

PMID: 40456394      Review.      

Alveolar bone loss is associated with oral cancer: a case-control study. 

Trumet L, Fuchs R, Backhaus J, Grötsch B, Galler K, Kesting M, Weber M.

Front Oral Health. 2025 May 9;6:1569491. doi: 10.3389/froh.2025.1569491. eCollection 2025.

PMID: 40416513      Free PMC article.      

Rheumatic? A diagnostic decision support tool for individuals suspecting rheumatic diseases: Mixed-methods usability and acceptability study. 

Jakobi S, Boy K, Wagner M, May S, Temiz A, Liphardt AM, Araujo E, Carmona L, Knevel R, Schett G, Knitza J, Muehlensiepen F, Morf H.

BMC Rheumatol. 2025 May 23;9(1):59. doi: 10.1186/s41927-025-00507-w.

PMID: 40410901      Free PMC article.      

Spatial multiomics decipher fibroblast-macrophage dynamics in systemic sclerosis. 

Li Z, Rius Rigau A, Xie W, Huang L, Ye W, Li YN, Matei AE, Bergmann C, Shao X, Zou H, Wang J, Pinello L, Distler JHW, He R, Liang M.

Ann Rheum Dis. 2025 Jul;84(7):1231-1245. doi: 10.1016/j.ard.2025.04.025. Epub 2025 May 22.

PMID: 40410053      

FDG-PET/CT as a useful tool for disease activity assessment in large vessel vasculitis in childhood. 

Krickau T, Atzinger A, Juengert J, Rech J, Rompel O, Hoerning A.

Pediatr Rheumatol Online J. 2025 May 9;23(1):48. doi: 10.1186/s12969-025-01091-6.

PMID: 40346570      Free PMC article.      No abstract available. 

RNA splicing modulator for Huntington's disease treatment induces peripheral neuropathy. 

Krach F, Boerstler T, Neubert S, Krumm L, Regensburger M, Winkler J, Winner B.

iScience. 2025 Apr 8;28(5):112380. doi: 10.1016/j.isci.2025.112380. eCollection 2025 May 16.

PMID: 40343270      Free PMC article.      

Author Correction: Matrix-producing neutrophils populate and shield the skin. 

Vicanolo T, Özcan A, Li JL, Huerta-López C, Ballesteros I, Rubio-Ponce A, Dumitru AC, Nicolás-Ávila JÁ, Molina-Moreno M, Reyes-Gutierrez P, Johnston AD, Martone C, Greto E, Quílez-Alvarez A, Calvo E, Bonzon-Kulichenko E, Álvarez-Velez R, Chooi MY, Kwok I, González-Bermúdez B, Malleret B, Espinosa FM, Zhang M, Wang YL, Sun D, Zhen Chong S, El-Armouche A, Kim KK, Udalova IA, Greco V, Garcia R, Vázquez J, Dopazo A, Plaza GR, Alegre-Cebollada J, Uderhardt S, Ng LG, Hidalgo A.

Nature. 2025 May;641(8065):E10. doi: 10.1038/s41586-025-09082-z.

PMID: 40335705      No abstract available. 

Multi-Epitope DC Vaccines with Melanoma Antigens for Immunotherapy of Melanoma. 

Seretis A, Amon L, Tripp CH, Cappellano G, Hornsteiner F, Dieckmann S, Vierthaler J, Ortner-Tobider D, Kanduth M, Steindl R, Boon L, den Haan JMM, Lehmann CHK, Dudziak D, Stoitzner P.

Vaccines (Basel). 2025 Mar 25;13(4):346. doi: 10.3390/vaccines13040346.

PMID: 40333215      Free PMC article.      

Endoscopic Management of Perforations, Gastrointestinal Leaks, and Fistulae. 

Hoffman A, Atreya R, Rath T, Dorlöchter C, Neurath MF.

Visc Med. 2025 Mar 20:1-12. doi: 10.1159/000545072. Online ahead of print.

PMID: 40330636      Free PMC article.      Review.      

Local immune effector cell-associated toxicity syndrome in CAR T-cell treated patients with autoimmune disease: an observational study. 

Hagen M, Müller F, Wirsching A, Kharboutli S, Spoerl S, Düsing C, Krickau T, Metzler M, Völkl S, Aigner M, Kretschmann S, Vasova I, Saake M, Schliep S, Kubacki T, Hunzelmann N, Bucci L, Taubmann J, Bergmann C, Györfi AH, Dietrich S, Distler JHW, Grieshaber-Bouyer R, Mackensen A, Schett G.

Lancet Rheumatol. 2025 Jun;7(6):e424-e433. doi: 10.1016/S2665-9913(25)00091-8. Epub 2025 Apr 30.

PMID: 40318690      

Integrated multimodel analysis of intestinal inflammation exposes key molecular features of preclinical and clinical IBD. 

Gonzalez-Acera M, Patankar JV, Erkert L, Cineus R, Gamez-Belmonte R, Leupold T, Bubeck M, Bao LL, Dinkel M, Wang R, Schickedanz L, Limberger H, Stolzer I, Gerlach K, Diemand L, Mascia F, Gupta P, Naschberger E, Koop K, Plattner C, Sturm G, Weigmann B, Günther C, Wirtz S, Stürzl M, Hildner K, Kühl AA, Siegmund B, Gießl A, Atreya R; TRR241 IBDome Consortium; Hegazy AN, Trajanoski Z, Neurath MF, Becker C.

Gut. 2025 Sep 8;74(10):1602-1615. doi: 10.1136/gutjnl-2024-333729.

PMID: 40301114      Free PMC article.      

Multiplex immunofluorescence assessment of macrophages and IL-23R in inflammatory and malignant diseases of the oral mucosa: a pilot study. 

Trumet L, Grötsch B, Agaimy A, Galler K, Geppert C, Winter L, Ries J, Kesting M, Weber M.

Front Immunol. 2025 Apr 14;16:1569490. doi: 10.3389/fimmu.2025.1569490. eCollection 2025.

PMID: 40297579      Free PMC article.      

IBDome: An integrated molecular, histopathological, and clinical atlas of inflammatory bowel diseases. 

Plattner C, Sturm G, Kühl AA, Atreya R, Carollo S, Gronauer R, Rieder D, Günther M, Ormanns S, Manzl C, Wirtz S, Meneghetti AR, Hegazy AN, Patankar JV, Carrero ZI; TRR241 IBDome Consortium; Neurath MF, Kather JN, Becker C, Siegmund B, Trajanoski Z.

bioRxiv [Preprint]. 2025 Apr 10:2025.03.26.645544. doi: 10.1101/2025.03.26.645544.

PMID: 40291692      Free PMC article.      Preprint.      

Clonal hematopoiesis-associated motoric deficits caused by monocyte-derived microglia accumulating in aging mice. 

Kim JS, Trzebanski S, Shin SH, Schori L, Frumer Friedman GR, Ilani NC, Kadam A, Vicario R, Aust O, Bugaeva P, Piatek S, Ismajli LK, Hoffmann CJ, Scheller M, Boura-Halfon S, Kaushansky N, Golani O, Solomon A, Liu Z, Amann L, Böhm-Sturm P, Koch SP, Wenger N; Netherlands Brain Bank; Ginhoux F, Prinz M, Avraham R, Harms C, Geissmann F, Müller-Tidow C, Uderhardt S, Milenkovic I, Shlush L, Jung S.

Cell Rep. 2025 May 27;44(5):115609. doi: 10.1016/j.celrep.2025.115609. Epub 2025 Apr 24.

PMID: 40279248      

Limited association between HRR gene alterations and HRD in molecular tumor board cancer samples: Who should be tested for HRD? 

Schubart C, Tögel L, Carta MG, Hetzner P, Helbig L, Zaglas C, Ziegler M, Stöhr R, Hölsken A, Hoyer J, Ferrazzi F, Neufert C, Lettmaier S, Pavel M, Golcher H, Mueller SK, Fuchs F, Schulmeyer CE, Beckmann MW, Wullich B, Agaimy A, Reis A, Hartmann A, Meidenbauer N, Spoerl S, Haller F, Moskalev EA.

Int J Cancer. 2025 Sep 1;157(5):964-979. doi: 10.1002/ijc.35457. Epub 2025 Apr 25.

PMID: 40278800      Free PMC article.      

Incomparable regional prevalence estimates of Neuromyelitis Optica due to lack of standardization: Comment on the article by Taskiran et.al. 

Temiz A, Tascilar K.

Mult Scler Relat Disord. 2025 Jun;98:106455. doi: 10.1016/j.msard.2025.106455. Epub 2025 Apr 17.

PMID: 40262475      No abstract available. 

Response to the correspondence on "CD19-CAR T-cell therapy induces deep tissue depletion of B cells". 

Tur C, Eckstein M, Schett G, Raimondo MG.

Ann Rheum Dis. 2025 Aug;84(8):e38-e39. doi: 10.1016/j.ard.2025.03.006. Epub 2025 Apr 17.

PMID: 40251073      No abstract available. 

BCMA CAR T cells in a patient with relapsing idiopathic inflammatory myositis after initial and repeat therapy with CD19 CAR T cells. 

Müller F, Wirsching A, Hagen M, Völkl S, Tur C, Raimondo MG, Taubmann J, Bucci L, Zhang L, Kretschmann S, Aigner M, Eckstein M, Spörl S, Kharboutli S, Böltz S, Atzinger A, Munoz L, Schett G, Mackensen A, Grieshaber-Bouyer R.

Nat Med. 2025 Jun;31(6):1793-1797. doi: 10.1038/s41591-025-03718-3. Epub 2025 Apr 17.

PMID: 40245922      Free PMC article.      

Advancement and independent validation of a deep learning-based tool for automated scoring of nail psoriasis severity using the modified nail psoriasis severity index. 

Kemenes S, Chang L, Schlereth M, Noversa de Sousa R, Minopoulou I, Fenzl P, Corte G, Yalcin Mutlu M, Höner MW, Sagonas I, Coppers B, Liphardt AM, Simon D, Kleyer A, Folle L, Sticherling M, Schett G, Maier A, Fagni F.

Front Med (Lausanne). 2025 Apr 2;12:1574413. doi: 10.3389/fmed.2025.1574413. eCollection 2025.

PMID: 40241894      Free PMC article.      

Influence of the Immune Checkpoint Inhibitors on the Hemostatic Potential of Blood Plasma. 

Patalakh I, Wandersee A, Schlüter J, Erdmann M, Hackstein H, Cunningham S.

Transfus Med Hemother. 2024 Aug 21;52(2):120-131. doi: 10.1159/000535926. eCollection 2025 Apr.

PMID: 40201622      Free PMC article.      

Markers of neutrophil activation and some immune and haematological indices in malaria infection during pregnancy. 

Chukwuanukwu RC, Agu CE, Ehiaghe A, Ezeagwuna D, Herrmann M, Udigwe G.

BMC Immunol. 2025 Apr 8;26(1):28. doi: 10.1186/s12865-025-00709-4.

PMID: 40200152      Free PMC article.      

TNF-α disrupts the malate-aspartate shuttle, driving metabolic rewiring in iPSC-derived enteric neural lineages from Parkinson's Disease patients. 

Ghirotto B, Gonçalves LE, Ruder V, James C, Gerasimova E, Rizo T, Wend H, Farrell M, Gerez JA, Prymaczok NC, Kuijs M, Shulman M, Hartebrodt A, Prots I, Gessner A, Zunke F, Winkler J, Blumenthal DB, Theis FJ, Riek R, Günther C, Neurath M, Gupta P, Winner B.

bioRxiv [Preprint]. 2025 Mar 26:2025.03.25.644826. doi: 10.1101/2025.03.25.644826.

PMID: 40196623      Free PMC article.      Preprint.      

Modulation of Host Immunity by Microbiome-Derived Indole-3-Propionic Acid and Other Bacterial Metabolites. 

Schütz B, Krause FF, Taudte RV, Zaiss MM, Luu M, Visekruna A.

Eur J Immunol. 2025 Apr;55(4):e202451594. doi: 10.1002/eji.202451594.

PMID: 40170399      Free PMC article.      Review.      

Immobilization by 21-days of bed rest causes changes in biomarkers of cartilage homeostasis in healthy individuals. 

Dreiner M, Godonou ET, Mündermann A, Tascilar K, Schett G, Zaucke F, Liphardt AM, Niehoff A.

Osteoarthr Cartil Open. 2025 Feb 28;7(2):100597. doi: 10.1016/j.ocarto.2025.100597. eCollection 2025 Jun.

PMID: 40144955      Free PMC article.      

The Influence of Indisulam on Human Immune Effector Cells: Is a Combination with Immunotherapy Feasible? 

Arnet L, Emilius L, Hamann A, Carmo-Fonseca M, Berking C, Dörrie J, Schaft N.

Pharmaceutics. 2025 Mar 14;17(3):368. doi: 10.3390/pharmaceutics17030368.

PMID: 40143032      Free PMC article.      

The effect of Rsk2 on TNFα-mediated bone loss in the TMJ and craniofacial skeleton. 

Georgi GM, Bachmann F, Luther J, Derer A, Heimel P, Tangl S, Kahl-Nieke B, LeBlanc A, Helms J, Schett G, Hirsch C, Gruber R, Amling M, Schinke T, Koehne T, Petersen J.

BMC Oral Health. 2025 Mar 26;25(1):435. doi: 10.1186/s12903-025-05779-9.

PMID: 40140815      Free PMC article.      

Derivation and validation of a non-invasive optoacoustic imaging biomarker for detection of patients with intermittent claudication. 

Caranovic M, Kempf J, Li Y, Regensburger AP, Günther JS, Träger AP, Lang W, Meyer A, Wagner AL, Woelfle J, Raming R, Paulus LP, Buehler A, Uter W, Uder M, Behrendt CA, Neurath MF, Waldner MJ, Knieling F, Rother U.

Commun Med (Lond). 2025 Mar 25;5(1):88. doi: 10.1038/s43856-025-00801-1.

PMID: 40133711      Free PMC article.      

CCR3 deficiency shifts adaptive to innate-driven immunity in asthma. 

Krammer S, Yang Z, Mitländer H, Grund JC, Geppert CI, Rieker RJ, Zirlik S, Finotto S.

J Allergy Clin Immunol Glob. 2025 Jan 30;4(2):100430. doi: 10.1016/j.jacig.2025.100430. eCollection 2025 May.

PMID: 40115969      Free PMC article.      

Matrix-producing neutrophils populate and shield the skin. 

Vicanolo T, Özcan A, Li JL, Huerta-López C, Ballesteros I, Rubio-Ponce A, Dumitru AC, Nicolás-Ávila JÁ, Molina-Moreno M, Reyes-Gutierrez P, Johnston AD, Martone C, Greto E, Quílez-Alvarez A, Calvo E, Bonzon-Kulichenko E, Álvarez-Velez R, Chooi MY, Kwok I, González-Bermúdez B, Malleret B, Espinosa FM, Zhang M, Wang YL, Sun D, Zhen Chong S, El-Armouche A, Kim KK, Udalova IA, Greco V, Garcia R, Vázquez J, Dopazo A, Plaza GR, Alegre-Cebollada J, Uderhardt S, Ng LG, Hidalgo A.

Nature. 2025 May;641(8063):740-748. doi: 10.1038/s41586-025-08741-5. Epub 2025 Mar 19.

PMID: 40108463      Free PMC article.      

A transcriptional atlas of gut-innervating neurons reveals activation of interferon signaling and ferroptosis during intestinal inflammation. 

Forster PM, Jakob MO, Yusuf D, Bubeck M, Limberger H, Luo Y, Thieme P, Polici A, Sterczyk N, Boulekou S, Bartel L, Cosovanu C, Witkowski M, González-Acera M, Kühl AA, Weidinger C; TRR241 IBDome Consortium; Backofen R, Hegazy AN, Patankar JV, Klose CSN.

Neuron. 2025 May 7;113(9):1333-1351.e7. doi: 10.1016/j.neuron.2025.02.018. Epub 2025 Mar 17.

PMID: 40101721      

[Systemic treatment of allergies]. 

Staubach P, Ghoreishi Y, Wagner N.

Dermatologie (Heidelb). 2025 Apr;76(4):211-218. doi: 10.1007/s00105-025-05483-3. Epub 2025 Mar 17.

PMID: 40097816      Review.      German.      

The intestinal barrier: a pivotal role in health, inflammation, and cancer. 

Neurath MF, Artis D, Becker C.

Lancet Gastroenterol Hepatol. 2025 Jun;10(6):573-592. doi: 10.1016/S2468-1253(24)00390-X. Epub 2025 Mar 11.

PMID: 40086468      Review.      

Transcriptome analysis to decipher the molecular underpinnings of response to treatment in systemic lupus erythematosus. 

Garantziotis P, Moysidou GS, Kapsala N, Flouda S, Nikolopoulos D, Chavatza K, Sentis G, Filia A, Malissovas N, Pieta A, Banos A, Katechis S, Fanouriakis A, Bertsias G, Boumpas DT.

RMD Open. 2025 Mar 12;11(1):e005050. doi: 10.1136/rmdopen-2024-005050.

PMID: 40081913      Free PMC article.      

Correction: Clinical characterization of common pathogenic variants of SOD1-ALS in Germany. 

Wiesenfarth M, Forouhideh-Wiesenfarth Y, Elmas Z, Parlak Ö, Weiland U, Herrmann C, Schuster J, Freischmidt A, Müller K, Siebert R, Günther K, Fröhlich E, Knehr A, Simak T, Bachhuber F, Regensburger M, Petri S, Klopstock T, Reilich P, Schöberl F, Schumann P, Körtvélyessy P, Meyer T, Ruf WP, Witzel S, Tumani H, Brenner D, Dorst J, Ludolph AC.

J Neurol. 2025 Mar 8;272(4):259. doi: 10.1007/s00415-025-12952-1.

PMID: 40056187      Free PMC article.      No abstract available. 

GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets. 

Dand N, Stuart PE, Bowes J, Ellinghaus D, Nititham J, Saklatvala JR, Teder-Laving M, Thomas LF, Traks T, Uebe S, Assmann G, Baudry D, Behrens F, Billi AC, Brown MA, Burkhardt H, Capon F, Chung R, Curtis CJ, Duckworth M, Ellinghaus E, FitzGerald O, Gerdes S, Griffiths CEM, Gulliver S, Helliwell PS, Ho P, Hoffmann P, Holmen OL, Huang ZM, Hveem K, Jadon D, Köhm M, Kraus C, Lamacchia C, Lee SH, Ma F, Mahil SK, McHugh N, McManus R, Modalsli EH, Nissen MJ, Nöthen M, Oji V, Oksenberg JR, Patrick MT, Perez White BE, Ramming A, Rech J, Rosen C, Sarkar MK, Schett G, Schmidt B, Tejasvi T, Traupe H, Voorhees JJ, Wacker EM, Warren RB, Wasikowski R, Weidinger S, Wen X, Zhang Z; BSTOP study group; Estonian Biobank research team; Barton A, Chandran V, Esko T, Foerster J, Franke A, Gladman DD, Gudjonsson JE, Gulliver W, Hüffmeier U, Kingo K, Kõks S, Liao W, Løset M, Mägi R, Nair RP, Rahman P, Reis A, Smith CH, Di Meglio P, Barker JN, Tsoi LC, Simpson MA, Elder JT.

Nat Commun. 2025 Feb 28;16(1):2051. doi: 10.1038/s41467-025-56719-8.

PMID: 40021644      Free PMC article.      

RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry. 

Perr J, Langen A, Almahayni K, Nestola G, Chai P, Lebedenko CG, Volk RF, Detrés D, Caldwell RM, Spiekermann M, Hemberger H, Bisaria N, Aiba T, Sánchez-Rivera FJ, Tzelepis K, Calo E, Möckl L, Zaro BW, Flynn RA.

Cell. 2025 Apr 3;188(7):1878-1895.e25. doi: 10.1016/j.cell.2025.01.040. Epub 2025 Feb 27.

PMID: 40020667      

Evaluation of Systemic Sclerosis Primary Heart Involvement and Chronic Heart Failure in the European Scleroderma Trials and Research Cohort. 

Györfi AH, Filla T, Polzin A, Tascilar K, Buch M, Tröbs M, Matei AE, Airo P, Balbir-Gurman A, Kuwert F, Mihai C, Kabala A, Graßhoff H, Callaghan J, Isomura Y, Mansour J, Spierings J, Tennoe AH, Selvi E, Riccieri V, Hoffmann-Vold AM, Bergmann C, Schett G, Hunzelmann N, van Laar JM, Saketkoo LA, Kuwana M, Siegert E, Riemekasten G, Distler O, du Four T, Smith V, Truchetet ME, Distler JHW; EUSTAR collaborators.

J Am Heart Assoc. 2025 Mar 4;14(5):e036730. doi: 10.1161/JAHA.124.036730. Epub 2025 Feb 26.

PMID: 40008525      Free PMC article.      

Avelumab mediates antibody-dependent cellular cytotoxicity against monocyte-derived dendritic cells through natural killer cells. 

Sauerer T, Bremm F, Beenen AC, Heger L, Dudziak D, Bosch NC, Erdmann M, Berking C, Schaft N, Dörrie J.

MedComm (2020). 2025 Feb 18;6(3):e70111. doi: 10.1002/mco2.70111. eCollection 2025 Mar.

PMID: 39974665      Free PMC article.      No abstract available. 

Impact of Different Low-Volume Concurrent Training Regimens on Cardiometabolic Health, Inflammation, and Fitness in Obese Metabolic Syndrome Patients. 

Reljic D, Herrmann HJ, Neurath MF, Zopf Y.

Nutrients. 2025 Jan 31;17(3):561. doi: 10.3390/nu17030561.

PMID: 39940419      Free PMC article.      Clinical Trial.      

Targeting autoimmunity with CD19-CAR T-cell therapy: efficacy and seroconversion in diffuse systemic sclerosis and rheumatoid arthritis. 

Albach FN, Minopoulou I, Wilhelm A, Biesen R, Kleyer A, Wiebe E, Fleischmann A, Frick M, Damm F, Gogolok J, Serve S, Locher BN, Borie D, Casteleyn V, Siegert E, Dörner T, Alexander T, Furth C, Zernicke J, Movassaghi K, Hütter-Krönke ML, Schrezenmeier E, Schneider U, Bullinger L, Krönke G, Penack O, Simon D.

Rheumatology (Oxford). 2025 Jun 1;64(6):4075-4077. doi: 10.1093/rheumatology/keaf077.

PMID: 39928370      No abstract available. 

Discrimination between Inflammatory and Fibrotic Activity in Crohn's Disease-Associated Ileal-Colonic Anastomotic Strictures by Combined Ga-68-FAPI-46 and F-18-FDG-PET/CT Imaging. 

Beck M, Kuwert T, Atzinger A, Gerner M, Hartmann A, Saake M, Uder M, Neurath MF, Atreya R.

Visc Med. 2025 Feb;41(1):1-13. doi: 10.1159/000542160. Epub 2024 Dec 20.

PMID: 39927190      

Relevance of capsule endoscopy in patients with obscure gastrointestinal bleeding - a comprehensive real-world study. 

Vetter M, Gebhardt S, Kessler G, Jesper D, Fischer S, Hagel AF, Siebler J, Konturek PC, Neurath MF, Zopf S.

J Physiol Pharmacol. 2024 Dec;75(6). doi: 10.26402/jpp.2024.6.07. Epub 2025 Feb 3.

PMID: 39923230      

Dynamic changes of extracellular vesicles during zebrafish organogenesis. 

Mulzer LM, Felger T, Muñoz LE, Engl G, Reutter H, Schiffer M, Jahromi LP, Boros FA, Zunke F, Arnold P, Hilger AC.

Cell Commun Signal. 2025 Feb 3;23(1):60. doi: 10.1186/s12964-025-02053-x.

PMID: 39901276      Free PMC article.      

Telomere Length Is Associated With Adverse Atrial Remodeling in Patients With Atrial Fibrillation. 

Pradhan K, Neupane B, Niehues P, Kirschner M, Beier F, Kuo CC, Hilbold EA, Bär C, Thoma OM, Waldner M, Vieri M, Brümmendorf TH, Tharmapalan V, Wagner W, Kleines M, Emrani M, Zink MD, Napp A, Marx N, Gramlich M.

J Am Heart Assoc. 2025 Feb 4;14(3):e037512. doi: 10.1161/JAHA.124.037512. Epub 2025 Feb 3.

PMID: 39895528      Free PMC article.      

Anti-CD19 CAR T cell therapy induces antibody seroconversion and complete B cell depletion in the bone marrow of a therapy-refractory patient with ANCA-associated vasculitis. 

Minopoulou I, Wilhelm A, Albach F, Kleyer A, Wiebe E, Schallenberg S, Fleischmann A, Frick M, Damm F, Gogolok J, Serve S, Locher BN, Borie D, Casteleyn V, Biesen R, Dörner T, Alexander T, Zernicke J, Movassaghi K, Hütter-Krönke ML, Schrezenmeier E, Schreiber A, Schneider U, Bullinger L, Krönke G, Penack O, Simon D.

Ann Rheum Dis. 2025 Mar;84(3):e4-e7. doi: 10.1016/j.ard.2025.01.008. Epub 2025 Jan 31.

PMID: 39893102      No abstract available. 

MRI Volumetric Changes in Perianal Fistulizing Crohn's Disease: Moving Toward a Novel Outcome Measure for Therapeutic Response. 

Atreya R, Neurath MF.

United European Gastroenterol J. 2025 Jun;13(5):667-668. doi: 10.1002/ueg2.12765. Epub 2025 Jan 30.

PMID: 39888247      Free PMC article.      No abstract available. 

CD19-CAR T-cell therapy induces deep tissue depletion of B cells. 

Tur C, Eckstein M, Velden J, Rauber S, Bergmann C, Auth J, Bucci L, Corte G, Hagen M, Wirsching A, Grieshaber-Bouyer R, Reis P, Kittan N, Wacker J, Rius Rigau A, Ramming A, D'Agostino MA, Hartmann A, Müller F, Mackensen A, Bozec A, Schett G, Raimondo MG.

Ann Rheum Dis. 2025 Jan;84(1):106-114. doi: 10.1136/ard-2024-226142. Epub 2025 Jan 2.

PMID: 39874224      

Analyzing Pathophysiology and Immune Cells and Their Cytokines and Mediators in Precision-Cut Slices of the Murine Lung. 

Tatcheff M, Carvalho C, Willar J, Nendel E, Krammer S, Chiriac MT, Zhou S, Geppert CI, Finotto S.

Curr Protoc. 2025 Jan;5(1):e70087. doi: 10.1002/cpz1.70087.

PMID: 39873159      Free PMC article.      

Exploring CAR T-Cell Dynamics: Balancing Potent Cytotoxicity and Controlled Inflammation in CAR T-Cells Derived from Systemic Sclerosis and Myositis Patients. 

Dingfelder J, Taubmann J, von Heydebrand F, Aigner M, Bergmann C, Knitza J, Park S, Cheng JK, Van Blarcom T, Schett G, Mackensen A, Lutzny-Geier G.

Int J Mol Sci. 2025 Jan 8;26(2):467. doi: 10.3390/ijms26020467.

PMID: 39859183      Free PMC article.      

TIFA renders intestinal epithelial cells responsive to microbial ADP-heptose and drives colonic inflammation in mice. 

Erkert L, Ruder B, Kabisch M, Gamez Belmonte R, Patankar JV, Gonzalez Acera M, Schödel L, Chiriac MT, Cineus R, Gnafakis S, Leupold T, Thoma OM, Stolzer I, Taut A, Thonn V, Zundler S, Günther C, Diefenbach A, Kühl AA, Hegazy AN, Waldner M, Basic M, Bleich A, Neurath MF, Wirtz S, Becker C; TRR241 IBDome Consortium.

Mucosal Immunol. 2025 Apr;18(2):453-466. doi: 10.1016/j.mucimm.2025.01.003. Epub 2025 Jan 20.

PMID: 39842611      

Guided Multispectral Optoacoustic Tomography for 3D Imaging of the Murine Colon. 

Buehler A, Brown EL, Eckstein M, Thoma OM, Wachter F, Mandelbaum H, Ludwig P, Claßen M, Oraiopoulou ME, Rother U, Neurath MF, Woelfle J, Waldner MJ, Friedrich O, Knieling F, Bohndiek SE, Regensburger AP.

Adv Sci (Weinh). 2025 Mar;12(10):e2413434. doi: 10.1002/advs.202413434. Epub 2025 Jan 21.

PMID: 39836529      Free PMC article.      

Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis. 

Jia Y, Li R, Li Y, Kachler K, Meng X, Gießl A, Qin Y, Zhang F, Liu N, Andreev D, Schett G, Bozec A.

Bone Res. 2025 Jan 16;13(1):9. doi: 10.1038/s41413-024-00384-y.

PMID: 39814705      Free PMC article.      

Unconventional Imaging Methods in Psoriatic Arthritis. 

Minopoulou I, Fagni F, Atzinger A, Albach F, Schett G, Krönke G, Kleyer A, Simon D.

Curr Rheumatol Rep. 2025 Jan 10;27(1):13. doi: 10.1007/s11926-024-01174-5.

PMID: 39792226      Free PMC article.      Review.      

Epithelial OPA1 links mitochondrial fusion to inflammatory bowel disease. 

Bao LL, Yu YQ, González-Acera M, Patankar JV, Giessl A, Sturm G, Kühl AA, Atreya R, Erkert L, Gámez-Belmonte R, Krug SM, Schmid B, Tripal P, Chiriac MT, Hildner K, Siegmund B, Wirtz S, Stürzl M, Mohamed Abdou M, Trajanoski Z; TRR241 IBDome Consortium; Neurath MF, Zorzano A, Becker C.

Sci Transl Med. 2025 Jan 15;17(781):eadn8699. doi: 10.1126/scitranslmed.adn8699. Epub 2025 Jan 15.

PMID: 39813315      

Loading of CAR-T cells with magnetic nanoparticles for controlled targeting suppresses inflammatory cytokine release and switches tumor cell death mechanism. 

Pfister F, Carnell LR, Löffler L, Boosz P, Schaft N, Dörrie J, Stein R, Lenz M, Spiecker E, Huber CM, Haddadin S, Berking C, Alexiou C, Janko C.

MedComm (2020). 2025 Jan 5;6(1):e70039. doi: 10.1002/mco2.70039. eCollection 2025 Jan.

PMID: 39764559      Free PMC article.      

Long-Term Safety and Effectiveness of Canakinumab in Patients with MKD/HIDS: Interim Analysis of the RELIANCE Registry. 

Oommen PT, Kallinich T, Rech J, Blank N, Weber-Arden J, Kuemmerle-Deschner JB.

Rheumatol Ther. 2025 Feb;12(1):137-155. doi: 10.1007/s40744-024-00733-7. Epub 2024 Dec 26.

PMID: 39724475      Free PMC article.      

Disturbed Spatial WNT Activation-A Potential Driver of the Reticularized Skin Phenotype in Systemic Sclerosis. 

Fakhouri SC, Zhu H, Li YN, Ronicke M, Rigau AR, Dees C, Konstantinidis L, Schmid R, Matei AE, Eckstein M, Geppert C, Ludolph I, Kreuter A, Sticherling M, Berking C, Horch RE, Schett G, Distler JHW, Bergmann C.

Arthritis Rheumatol. 2025 Jun;77(6):740-749. doi: 10.1002/art.43094. Epub 2025 Mar 11.

PMID: 39722197      Free PMC article.      

Optimized monitoring for immune checkpoint inhibitor induced myocarditis using high-sensitivity troponin-T. 

Tomsitz D, Grabmaier U, Spiro J, Nicolai L, French LE, Massberg S, Heinzerling L.

Eur J Cancer. 2025 Feb 5;216:115186. doi: 10.1016/j.ejca.2024.115186. Epub 2024 Dec 15.

PMID: 39708617      

The Role of Non-coding RNAs in Tumorigenesis, Diagnosis/Prognosis, and Therapeutic Strategies for Cutaneous Melanoma. 

Schaft N, Dörrie J.

Methods Mol Biol. 2025;2883:79-107. doi: 10.1007/978-1-0716-4290-0_4.

PMID: 39702705      Review.      

Improved survival of advanced melanoma patients receiving immunotherapy with concomitant antithrombotic therapy - A multicenter study on 2419 patients from the prospective skin cancer registry ADOReg. 

Kött J, Zell T, Zimmermann N, Rünger A, Smit DJ, Abeck F, Geidel G, Hansen-Abeck I, Heidrich I, Weichenthal M, Ugurel S, Leiter U, Berking C, Gutzmer R, Schadendorf D, Zimmer L, Livingstone E, Wasielewski IV, Mohr P, Meier F, Haferkamp S, Drexler K, Herbst R, Kellner I, Utikal J, Wohlfeil SA, Pföhler C, Adam L, Terheyden P, Ulrich J, Meiss F, Möbes M, Welzel J, Schilling B, Ziller F, Kaatz M, Kreuter A, Sindrilaru A, Dippel E, Sachse M, Weishaupt C, Hüning S, Heinzerling L, Loquai C, Schley G, Gambichler T, Löffler H, Grabbe S, Schultz E, Devereux N, Hassel JC, Simon JC, Raap U, Assaf C, Klemke CD, Sunderkötter C, Hofmann SC, Wenk S, Tronnier M, Thies S, Heppt MV, Eggermont A, Schulze HJ, Zouboulis CC, Tüting T, Bauer AT, Schneider SW, Gebhardt C.

Eur J Cancer. 2025 Jan;214:115159. doi: 10.1016/j.ejca.2024.115159. Epub 2024 Nov 30.

PMID: 39642845      

Colchicine inhibits monosodium urate crystal-mediated inflammation by influencing F-actin formation. 

Zhu L, Wang Y, Shan L, Xue Y, Schett G, Herrmann M, Liu L.

Biochim Biophys Acta Mol Basis Dis. 2025 Mar;1871(3):167602. doi: 10.1016/j.bbadis.2024.167602. Epub 2024 Dec 1.

PMID: 39626855      

Interferential Current Stimulation Enhances Rectal Motor Activity: Insights from an Isolated Perfused Porcine Model. 

Martel R, Boettcher M, Klinke Petrowsky M, Hoyos NA, Herrmann I, Magerl W, Herrmann M.

Eur J Pediatr Surg. 2025 Feb;35(1):60-70. doi: 10.1055/a-2482-5997. Epub 2024 Nov 25.

PMID: 39587047      

Recent advances in nuclear medicine and their role in inflammatory arthritis: focus on the emerging role of FAPI PET/CT. 

Schmidkonz C, Kuwert T, Götz TI, Ramming A, Atzinger A.

Skeletal Radiol. 2025 Nov;54(11):2243-2252. doi: 10.1007/s00256-024-04834-w. Epub 2024 Nov 25.

PMID: 39586916      Free PMC article.      Review.      

Metabolic rewiring controlled by HIF-1α tunes IgA-producing B-cell differentiation and intestinal inflammation. 

Meng X, Asadi-Asadabad S, Cao S, Song R, Lin Z, Safhi M, Qin Y, Tcheumi Tactoum E, Taudte V, Ekici A, Mielenz D, Wirtz S, Schett G, Bozec A.

Cell Mol Immunol. 2025 Jan;22(1):54-67. doi: 10.1038/s41423-024-01233-y. Epub 2024 Nov 14.

PMID: 39543372      Free PMC article.      

Intravenous Immunoglobulin Therapy for Pyoderma Gangrenosum: A Multicenter Retrospective Analysis in 81 Patients. 

Ronicke M, Sollfrank L, Vitus MV, Walter LJ, Krieter M, Moelleken M, Dissemond J, Schultz E, Lauffer F, von den Driesch P, Erfurt-Berge C.

Am J Clin Dermatol. 2025 Jan;26(1):139-146. doi: 10.1007/s40257-024-00904-w. Epub 2024 Nov 14.

PMID: 39541069      Free PMC article.      

Molecular Imaging: The New Frontier for Endoscopic Diagnosis and Personalization in Inflammatory Bowel Disease. 

Atreya R, Rath T, Neurath MF.

Gastrointest Endosc Clin N Am. 2025 Jan;35(1):255-263. doi: 10.1016/j.giec.2024.09.002. Epub 2024 Oct 10.

PMID: 39510691      Review.      

Tailored Bisacylphosphane Oxides for Precise Induction of Oxidative Stress-Mediated Cell Death in Biological Systems. 

Almahayni K, Salvador JB, Conti R, Widera A, Spiekermann M, Wehner D, Grützmacher H, Möckl L.

ACS Chem Biol. 2025 Jan 17;20(1):77-85. doi: 10.1021/acschembio.4c00399. Epub 2024 Nov 5.

PMID: 39498831      Free PMC article.      

Neutrophil-to-lymphocyte ratio as a biomarker for clinical response after autologous haematopoietic stem cell transplantation in systemic sclerosis. 

Keret S, Kaly L, Schett G, Bergmann C, Feldman E, Zuckerman T, Yehudai-Ofir D, Shouval A, Awisat A, Rosner I, Rozenbaum M, Boulman N, Sawaed A, Hardak E, Henes J, Slobodin G, Rimar D.

Rheumatology (Oxford). 2025 May 1;64(5):3160-3165. doi: 10.1093/rheumatology/keae606.

PMID: 39485492      

IL-23R-Specific Chimeric Antigen Receptor Tregs in Crohn's Disease: Dawn of a Cellular Immunotherapeutic Era? 

Atreya R, Neurath MF.

J Crohns Colitis. 2025 Apr 4;19(4):jjae159. doi: 10.1093/ecco-jcc/jjae159.

PMID: 39432833      No abstract available. 

Engineering Therapeutic Regulatory T Cells to Overexpress G Protein-Coupled Receptor 15 Improves Functional Fitness for In Vivo Gut Homing. 

Müller TM, Liu LJ, Wiesinger M; TRR241 IBDome Consortium; Neurath MF, Voskens CJ, Zundler S.

Gastroenterology. 2025 Feb;168(2):389-392.e4. doi: 10.1053/j.gastro.2024.10.003. Epub 2024 Oct 9.

PMID: 39389186      No abstract available. 

Integrin αVβ6: Autoantigen and Driver of Epithelial Remodeling in Colon and Bile Ducts in Primary Sclerosing Cholangitis and Inflammatory Bowel Disease. 

Roth D, Düll MM, Horst LJ, Lindemann A, Malzer X, Koop K, Zundler S, Vetter M, Jefremow A, Atreya R, Geppert C, Weidemann S, Waldner MJ, Dietrich P, Günther C, Munoz LE, Herrmann M, Scheffold A, Neurath MF, Siebler J, Schramm C, Kremer AE, Leppkes M.

J Crohns Colitis. 2025 Feb 4;19(2):jjae131. doi: 10.1093/ecco-jcc/jjae131.

PMID: 39212221      

Efficacy of interventions for cutaneous squamous cell carcinoma in situ (Bowen's disease): A systematic review and meta-analysis of proportions. 

Petzold A, Wessely A, Steeb T, Berking C, Heppt MV.

J Eur Acad Dermatol Venereol. 2025 Mar;39(3):543-554. doi: 10.1111/jdv.20267. Epub 2024 Aug 16.

PMID: 39148440      Free PMC article.      

Clinical Pharmacist Counselling Improves Long-term Medication Safety and Patient-reported Outcomes in Anti-TNF-treated Patients With Inflammatory Bowel Diseases: The Prospective, Randomized AdPhaNCED Trial. 

Plechschmidt J, Fietkau K, Hepp T, Dietrich P, Fischer S, Krebs S, Neurath MF, Dörje F, Atreya R.

Inflamm Bowel Dis. 2025 Jan 6;31(1):77-86. doi: 10.1093/ibd/izae040.

PMID: 38507608      Free PMC article.      Clinical Trial.      

Preventive effects of early immunosuppressive treatment on the development of interstitial lung disease in systemic sclerosis. 

Velauthapillai A, Bootsma MFR, Bruni C, Bergmann C, Matucci-Cerinic M, Launay D, Riemekasten G, Garzanova L, Airò P, Rezus E, da Silva JAP, Del Galdo F, Hunzelmann N, Chung LS, Krasowska D, Distler O, van den Ende CHM, Vonk MC; EUSTAR Collaborators.

Rheumatology (Oxford). 2025 Dec 1;64(SI):SI122-SI130. doi: 10.1093/rheumatology/keae375.

PMID: 39037917      Free PMC article.