Links zu Publikationen 2025

Immobilization by 21-days of bed rest causes changes in biomarkers of cartilage homeostasis in healthy individuals. 

Dreiner M, Godonou ET, Mündermann A, Tascilar K, Schett G, Zaucke F, Liphardt AM, Niehoff A.

Osteoarthr Cartil Open. 2025 Feb 28;7(2):100597. doi: 10.1016/j.ocarto.2025.100597. eCollection 2025 Jun.

PMID: 40144955 Free PMC article. 

CCR3 deficiency shifts adaptive to innate-driven immunity in asthma. 

Krammer S, Yang Z, Mitländer H, Grund JC, Geppert CI, Rieker RJ, Zirlik S, Finotto S.

J Allergy Clin Immunol Glob. 2025 Jan 30;4(2):100430. doi: 10.1016/j.jacig.2025.100430. eCollection 2025 May.

PMID: 40115969 Free PMC article. 

Integrated multimodel analysis of intestinal inflammation exposes key molecular features of preclinical and clinical IBD. 

Gonzalez-Acera M, Patankar JV, Erkert L, Cineus R, Gamez-Belmonte R, Leupold T, Bubeck M, Bao LL, Dinkel M, Wang R, Schickedanz L, Limberger H, Stolzer I, Gerlach K, Diemand L, Mascia F, Gupta P, Naschberger E, Koop K, Plattner C, Sturm G, Weigmann B, Günther C, Wirtz S, Stürzl M, Hildner K, Kühl AA, Siegmund B, Gießl A, Atreya R; TRR241 IBDome Consortium; Hegazy AN, Trajanoski Z, Neurath MF, Becker C.

Gut. 2025 Apr 29:gutjnl-2024-333729. doi: 10.1136/gutjnl-2024-333729. Online ahead of print.

PMID: 40301114 

Limited association between HRR gene alterations and HRD in molecular tumor board cancer samples: Who should be tested for HRD? 

Schubart C, Tögel L, Carta MG, Hetzner P, Helbig L, Zaglas C, Ziegler M, Stöhr R, Hölsken A, Hoyer J, Ferrazzi F, Neufert C, Lettmaier S, Pavel M, Golcher H, Mueller SK, Fuchs F, Schulmeyer CE, Beckmann MW, Wullich B, Agaimy A, Reis A, Hartmann A, Meidenbauer N, Spoerl S, Haller F, Moskalev EA.

Int J Cancer. 2025 Apr 25. doi: 10.1002/ijc.35457. Online ahead of print.

PMID: 40278800 

Clonal hematopoiesis-associated motoric deficits caused by monocyte-derived microglia accumulating in aging mice. 

Kim JS, Trzebanski S, Shin SH, Schori L, Frumer Friedman GR, Ilani NC, Kadam A, Vicario R, Aust O, Bugaeva P, Piatek S, Ismajli LK, Hoffmann CJ, Scheller M, Boura-Halfon S, Kaushansky N, Golani O, Solomon A, Liu Z, Amann L, Böhm-Sturm P, Koch SP, Wenger N; Netherlands Brain Bank; Ginhoux F, Prinz M, Avraham R, Harms C, Geissmann F, Müller-Tidow C, Uderhardt S, Milenkovic I, Shlush L, Jung S.

Cell Rep. 2025 Apr 24;44(5):115609. doi: 10.1016/j.celrep.2025.115609. Online ahead of print.

PMID: 40279248 

Incomparable regional prevalence estimates of Neuromyelitis Optica due to lack of standardization: Comment on the article by Taskiran et.al. 

Temiz A, Tascilar K.

Mult Scler Relat Disord. 2025 Apr 17;98:106455. doi: 10.1016/j.msard.2025.106455. Online ahead of print.

PMID: 40262475 No abstract available. 

Response to the correspondence on "CD19-CAR T-cell therapy induces deep tissue depletion of B cells". 

Tur C, Eckstein M, Schett G, Raimondo MG.

Ann Rheum Dis. 2025 Apr 17:S0003-4967(25)00825-8. doi: 10.1016/j.ard.2025.03.006. Online ahead of print.

PMID: 40251073 No abstract available. 

BCMA-CAR T-cells in a patient with relapsing idiopathic inflammatory myositis after CD19-CAR T-cells. 

Müller F, Wirsching A, Hagen M, Völkl S, Tur C, Raimondo MG, Taubmann J, Bucci L, Zhang L, Kretschmann S, Aigner M, Eckstein M, Spörl S, Kharboutli S, Böltz S, Atzinger A, Munoz L, Schett G, Mackensen A, Grieshaber-Bouyer R.

Nat Med. 2025 Apr 17. doi: 10.1038/s41591-025-03718-3. Online ahead of print.

PMID: 40245922 

Multiplex immunofluorescence assessment of macrophages and IL-23R in inflammatory and malignant diseases of the oral mucosa: a pilot study. 

Trumet L, Grötsch B, Agaimy A, Galler K, Geppert C, Winter L, Ries J, Kesting M, Weber M.

Front Immunol. 2025 Apr 14;16:1569490. doi: 10.3389/fimmu.2025.1569490. eCollection 2025.

PMID: 40297579 Free PMC article. 

Markers of neutrophil activation and some immune and haematological indices in malaria infection during pregnancy. 

Chukwuanukwu RC, Agu CE, Ehiaghe A, Ezeagwuna D, Herrmann M, Udigwe G.

BMC Immunol. 2025 Apr 8;26(1):28. doi: 10.1186/s12865-025-00709-4.

PMID: 40200152 Free PMC article. 

IL-23R-Specific Chimeric Antigen Receptor Tregs in Crohn's Disease: Dawn of a Cellular Immunotherapeutic Era? 

Atreya R, Neurath MF.

J Crohns Colitis. 2025 Apr 4;19(4):jjae159. doi: 10.1093/ecco-jcc/jjae159.

PMID: 39432833 No abstract available. 

RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry. 

Perr J, Langen A, Almahayni K, Nestola G, Chai P, Lebedenko CG, Volk RF, Detrés D, Caldwell RM, Spiekermann M, Hemberger H, Bisaria N, Aiba T, Sánchez-Rivera FJ, Tzelepis K, Calo E, Möckl L, Zaro BW, Flynn RA.

Cell. 2025 Apr 3;188(7):1878-1895.e25. doi: 10.1016/j.cell.2025.01.040. Epub 2025 Feb 27.

PMID: 40020667 

Advancement and independent validation of a deep learning-based tool for automated scoring of nail psoriasis severity using the modified nail psoriasis severity index. 

Kemenes S, Chang L, Schlereth M, Noversa de Sousa R, Minopoulou I, Fenzl P, Corte G, Yalcin Mutlu M, Höner MW, Sagonas I, Coppers B, Liphart AM, Simon D, Kleyer A, Folle L, Sticherling M, Schett G, Maier A, Fagni F.

Front Med (Lausanne). 2025 Apr 2;12:1574413. doi: 10.3389/fmed.2025.1574413. eCollection 2025.

PMID: 40241894 Free PMC article. 

Influence of the Immune Checkpoint Inhibitors on the Hemostatic Potential of Blood Plasma. 

Patalakh I, Wandersee A, Schlüter J, Erdmann M, Hackstein H, Cunningham S.

Transfus Med Hemother. 2024 Aug 21;52(2):120-131. doi: 10.1159/000535926. eCollection 2025 Apr.

PMID: 40201622 Free PMC article. 

Modulation of Host Immunity by Microbiome-Derived Indole-3-Propionic Acid and Other Bacterial Metabolites. 

Schütz B, Krause FF, Taudte RV, Zaiss MM, Luu M, Visekruna A.

Eur J Immunol. 2025 Apr;55(4):e202451594. doi: 10.1002/eji.202451594.

PMID: 40170399 Free PMC article. Review.

[Systemic treatment of allergies]. 

Staubach P, Ghoreishi Y, Wagner N.

Dermatologie (Heidelb). 2025 Apr;76(4):211-218. doi: 10.1007/s00105-025-05483-3. Epub 2025 Mar 17.

PMID: 40097816 Review.German. 

TIFA renders intestinal epithelial cells responsive to microbial ADP-heptose and drives colonic inflammation in mice. 

Erkert L, Ruder B, Kabisch M, Gamez Belmonte R, Patankar JV, Gonzalez Acera M, Schödel L, Chiriac MT, Cineus R, Gnafakis S, Leupold T, Thoma OM, Stolzer I, Taut A, Thonn V, Zundler S, Günther C, Diefenbach A, Kühl AA, Hegazy AN, Waldner M, Basic M, Bleich A, Neurath MF, Wirtz S, Becker C; TRR241 IBDome Consortium.

Mucosal Immunol. 2025 Apr;18(2):453-466. doi: 10.1016/j.mucimm.2025.01.003. Epub 2025 Jan 20.

PMID: 39842611 

TNF-α disrupts the malate-aspartate shuttle, driving metabolic rewiring in iPSC-derived enteric neural lineages from Parkinson's Disease patients. 

Ghirotto B, Gonçalves LE, Ruder V, James C, Gerasimova E, Rizo T, Wend H, Farrell M, Gerez JA, Prymaczok NC, Kuijs M, Shulman M, Hartebrodt A, Prots I, Gessner A, Zunke F, Winkler J, Blumenthal DB, Theis FJ, Riek R, Günther C, Neurath M, Gupta P, Winner B.

bioRxiv [Preprint]. 2025 Mar 26:2025.03.25.644826. doi: 10.1101/2025.03.25.644826.

PMID: 40196623 Free PMC article. Preprint.

The effect of Rsk2 on TNFα-mediated bone loss in the TMJ and craniofacial skeleton. 

Georgi GM, Bachmann F, Luther J, Derer A, Heimel P, Tangl S, Kahl-Nieke B, LeBlanc A, Helms J, Schett G, Hirsch C, Gruber R, Amling M, Schinke T, Koehne T, Petersen J.

BMC Oral Health. 2025 Mar 26;25(1):435. doi: 10.1186/s12903-025-05779-9.

PMID: 40140815 Free PMC article. 

Derivation and validation of a non-invasive optoacoustic imaging biomarker for detection of patients with intermittent claudication. 

Caranovic M, Kempf J, Li Y, Regensburger AP, Günther JS, Träger AP, Lang W, Meyer A, Wagner AL, Woelfle J, Raming R, Paulus LP, Buehler A, Uter W, Uder M, Behrendt CA, Neurath MF, Waldner MJ, Knieling F, Rother U.

Commun Med (Lond). 2025 Mar 25;5(1):88. doi: 10.1038/s43856-025-00801-1.

PMID: 40133711 Free PMC article. 

Matrix-producing neutrophils populate and shield the skin. 

Vicanolo T, Özcan A, Li JL, Huerta-López C, Ballesteros I, Rubio-Ponce A, Dumitru AC, Nicolás-Ávila JÁ, Molina-Moreno M, Reyes-Gutierrez P, Johnston AD, Martone C, Greto E, Quílez-Alvarez A, Calvo E, Bonzon-Kulichenko E, Álvarez-Velez R, Chooi MY, Kwok I, González-Bermúdez B, Malleret B, Espinosa FM, Zhang M, Wang YL, Sun D, Zhen Chong S, El-Armouche A, Kim KK, Udalova IA, Greco V, Garcia R, Vázquez J, Dopazo A, Plaza GR, Alegre-Cebollada J, Uderhardt S, Ng LG, Hidalgo A.

Nature. 2025 Mar 19. doi: 10.1038/s41586-025-08741-5. Online ahead of print.

PMID: 40108463 

A transcriptional atlas of gut-innervating neurons reveals activation of interferon signaling and ferroptosis during intestinal inflammation. 

Forster PM, Jakob MO, Yusuf D, Bubeck M, Limberger H, Luo Y, Thieme P, Polici A, Sterczyk N, Boulekou S, Bartel L, Cosovanu C, Witkowski M, González-Acera M, Kühl AA, Weidinger C; TRR241 IBDome Consortium; Backofen R, Hegazy AN, Patankar JV, Klose CSN.

Neuron. 2025 Mar 17:S0896-6273(25)00136-9. doi: 10.1016/j.neuron.2025.02.018. Online ahead of print.

PMID: 40101721 

The Influence of Indisulam on Human Immune Effector Cells: Is a Combination with Immunotherapy Feasible? 

Arnet L, Emilius L, Hamann A, Carmo-Fonseca M, Berking C, Dörrie J, Schaft N.

Pharmaceutics. 2025 Mar 14;17(3):368. doi: 10.3390/pharmaceutics17030368.

PMID: 40143032 Free PMC article. 

Transcriptome analysis to decipher the molecular underpinnings of response to treatment in systemic lupus erythematosus. 

Garantziotis P, Moysidou GS, Kapsala N, Flouda S, Nikolopoulos D, Chavatza K, Sentis G, Filia A, Malissovas N, Pieta A, Banos A, Katechis S, Fanouriakis A, Bertsias G, Boumpas DT.

RMD Open. 2025 Mar 12;11(1):e005050. doi: 10.1136/rmdopen-2024-005050.

PMID: 40081913 Free PMC article. 

The intestinal barrier: a pivotal role in health, inflammation, and cancer. 

Neurath MF, Artis D, Becker C.

Lancet Gastroenterol Hepatol. 2025 Mar 11:S2468-1253(24)00390-X. doi: 10.1016/S2468-1253(24)00390-X. Online ahead of print.

PMID: 40086468 Review.

Correction: Clinical characterization of common pathogenic variants of SOD1-ALS in Germany. 

Wiesenfarth M, Forouhideh-Wiesenfarth Y, Elmas Z, Parlak Ö, Weiland U, Herrmann C, Schuster J, Freischmidt A, Müller K, Siebert R, Günther K, Fröhlich E, Knehr A, Simak T, Bachhuber F, Regensburger M, Petri S, Klopstock T, Reilich P, Schöberl F, Schumann P, Körtvélyessy P, Meyer T, Ruf WP, Witzel S, Tumani H, Brenner D, Dorst J, Ludolph AC.

J Neurol. 2025 Mar 8;272(4):259. doi: 10.1007/s00415-025-12952-1.

PMID: 40056187 Free PMC article. No abstract available. 

Evaluation of Systemic Sclerosis Primary Heart Involvement and Chronic Heart Failure in the European Scleroderma Trials and Research Cohort. 

Györfi AH, Filla T, Polzin A, Tascilar K, Buch M, Tröbs M, Matei AE, Airo P, Balbir-Gurman A, Kuwert F, Mihai C, Kabala A, Graßhoff H, Callaghan J, Isomura Y, Mansour J, Spierings J, Tennoe AH, Selvi E, Riccieri V, Hoffmann-Vold AM, Bergmann C, Schett G, Hunzelmann N, van Laar JM, Saketkoo LA, Kuwana M, Siegert E, Riemekasten G, Distler O, du Four T, Smith V, Truchetet ME, Distler JHW; EUSTAR collaborators.

J Am Heart Assoc. 2025 Mar 4;14(5):e036730. doi: 10.1161/JAHA.124.036730. Epub 2025 Feb 26.

PMID: 40008525 

Avelumab mediates antibody-dependent cellular cytotoxicity against monocyte-derived dendritic cells through natural killer cells. 

Sauerer T, Bremm F, Beenen AC, Heger L, Dudziak D, Bosch NC, Erdmann M, Berking C, Schaft N, Dörrie J.

MedComm (2020). 2025 Feb 18;6(3):e70111. doi: 10.1002/mco2.70111. eCollection 2025 Mar.

PMID: 39974665 Free PMC article. No abstract available. 

Anti-CD19 CAR T cell therapy induces antibody seroconversion and complete B cell depletion in the bone marrow of a therapy-refractory patient with ANCA-associated vasculitis. 

Minopoulou I, Wilhelm A, Albach F, Kleyer A, Wiebe E, Schallenberg S, Fleischmann A, Frick M, Damm F, Gogolok J, Serve S, Locher BN, Borie D, Casteleyn V, Biesen R, Dörner T, Alexander T, Zernicke J, Movassaghi K, Hütter-Krönke ML, Schrezenmeier E, Schreiber A, Schneider U, Bullinger L, Krönke G, Penack O, Simon D.

Ann Rheum Dis. 2025 Mar;84(3):e4-e7. doi: 10.1016/j.ard.2025.01.008. Epub 2025 Jan 31.

PMID: 39893102 No abstract available. 

Guided Multispectral Optoacoustic Tomography for 3D Imaging of the Murine Colon. 

Buehler A, Brown EL, Eckstein M, Thoma OM, Wachter F, Mandelbaum H, Ludwig P, Claßen M, Oraiopoulou ME, Rother U, Neurath MF, Woelfle J, Waldner MJ, Friedrich O, Knieling F, Bohndiek SE, Regensburger AP.

Adv Sci (Weinh). 2025 Mar;12(10):e2413434. doi: 10.1002/advs.202413434. Epub 2025 Jan 21.

PMID: 39836529 Free PMC article. 

Colchicine inhibits monosodium urate crystal-mediated inflammation by influencing F-actin formation. 

Zhu L, Wang Y, Shan L, Xue Y, Schett G, Herrmann M, Liu L.

Biochim Biophys Acta Mol Basis Dis. 2025 Mar;1871(3):167602. doi: 10.1016/j.bbadis.2024.167602. Epub 2024 Dec 1.

PMID: 39626855 

Efficacy of interventions for cutaneous squamous cell carcinoma in situ (Bowen's disease): A systematic review and meta-analysis of proportions. 

Petzold A, Wessely A, Steeb T, Berking C, Heppt MV.

J Eur Acad Dermatol Venereol. 2025 Mar;39(3):543-554. doi: 10.1111/jdv.20267. Epub 2024 Aug 16.

PMID: 39148440 Free PMC article. Review.

GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets. 

Dand N, Stuart PE, Bowes J, Ellinghaus D, Nititham J, Saklatvala JR, Teder-Laving M, Thomas LF, Traks T, Uebe S, Assmann G, Baudry D, Behrens F, Billi AC, Brown MA, Burkhardt H, Capon F, Chung R, Curtis CJ, Duckworth M, Ellinghaus E, FitzGerald O, Gerdes S, Griffiths CEM, Gulliver S, Helliwell PS, Ho P, Hoffmann P, Holmen OL, Huang ZM, Hveem K, Jadon D, Köhm M, Kraus C, Lamacchia C, Lee SH, Ma F, Mahil SK, McHugh N, McManus R, Modalsli EH, Nissen MJ, Nöthen M, Oji V, Oksenberg JR, Patrick MT, Perez White BE, Ramming A, Rech J, Rosen C, Sarkar MK, Schett G, Schmidt B, Tejasvi T, Traupe H, Voorhees JJ, Wacker EM, Warren RB, Wasikowski R, Weidinger S, Wen X, Zhang Z; BSTOP study group; Estonian Biobank research team; Barton A, Chandran V, Esko T, Foerster J, Franke A, Gladman DD, Gudjonsson JE, Gulliver W, Hüffmeier U, Kingo K, Kõks S, Liao W, Løset M, Mägi R, Nair RP, Rahman P, Reis A, Smith CH, Di Meglio P, Barker JN, Tsoi LC, Simpson MA, Elder JT.

Nat Commun. 2025 Feb 28;16(1):2051. doi: 10.1038/s41467-025-56719-8.

PMID: 40021644 Free PMC article. 

Targeting autoimmunity with CD19-CAR T cell therapy: efficacy and seroconversion in diffuse systemic sclerosis and rheumatoid arthritis. 

Albach FN, Minopoulou I, Wilhelm A, Biesen R, Kleyer A, Wiebe E, Fleischmann A, Frick M, Damm F, Gogolok J, Serve S, Locher BN, Borie D, Casteleyn V, Siegert E, Dörner T, Alexander T, Furth C, Zernicke J, Movassaghi K, Hütter-Krönke ML, Schrezenmeier E, Schneider U, Bullinger L, Krönke G, Penack O, Simon D.

Rheumatology (Oxford). 2025 Feb 10:keaf077. doi: 10.1093/rheumatology/keaf077. Online ahead of print.

PMID: 39928370 No abstract available.

Optimized monitoring for immune checkpoint inhibitor induced myocarditis using high-sensitivity troponin-T. 

Tomsitz D, Grabmaier U, Spiro J, Nicolai L, French LE, Massberg S, Heinzerling L.

Eur J Cancer. 2025 Feb 5;216:115186. doi: 10.1016/j.ejca.2024.115186. Epub 2024 Dec 15.

PMID: 39708617 

Telomere Length Is Associated With Adverse Atrial Remodeling in Patients With Atrial Fibrillation. 

Pradhan K, Neupane B, Niehues P, Kirschner M, Beier F, Kuo CC, Hilbold EA, Bär C, Thoma OM, Waldner M, Vieri M, Brümmendorf TH, Tharmapalan V, Wagner W, Kleines M, Emrani M, Zink MD, Napp A, Marx N, Gramlich M.

J Am Heart Assoc. 2025 Feb 4;14(3):e037512. doi: 10.1161/JAHA.124.037512. Epub 2025 Feb 3.

PMID: 39895528 

Integrin αVβ6: Autoantigen and Driver of Epithelial Remodeling in Colon and Bile Ducts in Primary Sclerosing Cholangitis and Inflammatory Bowel Disease. 

Roth D, Düll MM, Horst LJ, Lindemann A, Malzer X, Koop K, Zundler S, Vetter M, Jefremow A, Atreya R, Geppert C, Weidemann S, Waldner MJ, Dietrich P, Günther C, Munoz LE, Herrmann M, Scheffold A, Neurath MF, Siebler J, Schramm C, Kremer AE, Leppkes M.

J Crohns Colitis. 2025 Feb 4;19(2):jjae131. doi: 10.1093/ecco-jcc/jjae131.

PMID: 39212221 

Dynamic changes of extracellular vesicles during zebrafish organogenesis. 

Mulzer LM, Felger T, Muñoz LE, Engl G, Reutter H, Schiffer M, Jahromi LP, Boros FA, Zunke F, Arnold P, Hilger AC.

Cell Commun Signal. 2025 Feb 3;23(1):60. doi: 10.1186/s12964-025-02053-x.

PMID: 39901276 Free PMC article. 

Discrimination between Inflammatory and Fibrotic Activity in Crohn's Disease-Associated Ileal-Colonic Anastomotic Strictures by Combined Ga-68-FAPI-46 and F-18-FDG-PET/CT Imaging. 

Beck M, Kuwert T, Atzinger A, Gerner M, Hartmann A, Saake M, Uder M, Neurath MF, Atreya R.

Visc Med. 2025 Feb;41(1):1-13. doi: 10.1159/000542160. Epub 2024 Dec 20.

PMID: 39927190 

[Update on the pathophysiology, prediction and prevention of inflammatory bowel diseases]. 

Fischer S, Neurath MF.

Inn Med (Heidelb). 2025 Feb;66(2):137-145. doi: 10.1007/s00108-024-01838-5. Epub 2025 Jan 20.

PMID: 39833377 Review.German. 

Long-Term Safety and Effectiveness of Canakinumab in Patients with MKD/HIDS: Interim Analysis of the RELIANCE Registry. 

Oommen PT, Kallinich T, Rech J, Blank N, Weber-Arden J, Kuemmerle-Deschner JB.

Rheumatol Ther. 2025 Feb;12(1):137-155. doi: 10.1007/s40744-024-00733-7. Epub 2024 Dec 26.

PMID: 39724475 Free PMC article. 

Interferential Current Stimulation Enhances Rectal Motor Activity: Insights from an Isolated Perfused Porcine Model. 

Martel R, Boettcher M, Klinke Petrowsky M, Hoyos NA, Herrmann I, Magerl W, Herrmann M.

Eur J Pediatr Surg. 2025 Feb;35(1):60-70. doi: 10.1055/a-2482-5997. Epub 2024 Nov 25.

PMID: 39587047 

Engineering Therapeutic Regulatory T Cells to Overexpress G Protein-Coupled Receptor 15 Improves Functional Fitness for In Vivo Gut Homing. 

Müller TM, Liu LJ, Wiesinger M; TRR241 IBDome Consortium; Neurath MF, Voskens CJ, Zundler S.

Gastroenterology. 2025 Feb;168(2):389-392.e4. doi: 10.1053/j.gastro.2024.10.003. Epub 2024 Oct 9.

PMID: 39389186 No abstract available. 

Impact of Different Low-Volume Concurrent Training Regimens on Cardiometabolic Health, Inflammation, and Fitness in Obese Metabolic Syndrome Patients. 

Reljic D, Herrmann HJ, Neurath MF, Zopf Y.

Nutrients. 2025 Jan 31;17(3):561. doi: 10.3390/nu17030561.

PMID: 39940419 Free PMC article. Clinical Trial. 

MRI Volumetric Changes in Perianal Fistulizing Crohn's Disease: Moving Toward a Novel Outcome Measure for Therapeutic Response. 

Atreya R, Neurath MF.

United European Gastroenterol J. 2025 Jan 30. doi: 10.1002/ueg2.12765. Online ahead of print.

PMID: 39888247 No abstract available. 

Tailored Bisacylphosphane Oxides for Precise Induction of Oxidative Stress-Mediated Cell Death in Biological Systems. 

Almahayni K, Salvador JB, Conti R, Widera A, Spiekermann M, Wehner D, Grützmacher H, Möckl L.

ACS Chem Biol. 2025 Jan 17;20(1):77-85. doi: 10.1021/acschembio.4c00399. Epub 2024 Nov 5.

PMID: 39498831 Free PMC article. 

Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis. 

Jia Y, Li R, Li Y, Kachler K, Meng X, Gießl A, Qin Y, Zhang F, Liu N, Andreev D, Schett G, Bozec A.

Bone Res. 2025 Jan 16;13(1):9. doi: 10.1038/s41413-024-00384-y.

PMID: 39814705 Free PMC article. 

Epithelial OPA1 links mitochondrial fusion to inflammatory bowel disease. 

Bao LL, Yu YQ, González-Acera M, Patankar JV, Giessl A, Sturm G, Kühl AA, Atreya R, Erkert L, Gámez-Belmonte R, Krug SM, Schmid B, Tripal P, Chiriac MT, Hildner K, Siegmund B, Wirtz S, Stürzl M, Mohamed Abdou M, Trajanoski Z; TRR241 IBDome Consortium; Neurath MF, Zorzano A, Becker C.

Sci Transl Med. 2025 Jan 15;17(781):eadn8699. doi: 10.1126/scitranslmed.adn8699. Epub 2025 Jan 15.

PMID: 39813315 

Unconventional Imaging Methods in Psoriatic Arthritis. 

Minopoulou I, Fagni F, Atzinger A, Albach F, Schett G, Krönke G, Kleyer A, Simon D.

Curr Rheumatol Rep. 2025 Jan 10;27(1):13. doi: 10.1007/s11926-024-01174-5.

PMID: 39792226 Free PMC article. Review.

Exploring CAR T-Cell Dynamics: Balancing Potent Cytotoxicity and Controlled Inflammation in CAR T-Cells Derived from Systemic Sclerosis and Myositis Patients. 

Dingfelder J, Taubmann J, von Heydebrand F, Aigner M, Bergmann C, Knitza J, Park S, Cheng JK, Van Blarcom T, Schett G, Mackensen A, Lutzny-Geier G.

Int J Mol Sci. 2025 Jan 8;26(2):467. doi: 10.3390/ijms26020467.

PMID: 39859183 Free PMC article. 

Clinical Pharmacist Counselling Improves Long-term Medication Safety and Patient-reported Outcomes in Anti-TNF-treated Patients With Inflammatory Bowel Diseases: The Prospective, Randomized AdPhaNCED Trial. 

Plechschmidt J, Fietkau K, Hepp T, Dietrich P, Fischer S, Krebs S, Neurath MF, Dörje F, Atreya R.

Inflamm Bowel Dis. 2025 Jan 6;31(1):77-86. doi: 10.1093/ibd/izae040.

PMID: 38507608 Free PMC article. Clinical Trial. 

Loading of CAR-T cells with magnetic nanoparticles for controlled targeting suppresses inflammatory cytokine release and switches tumor cell death mechanism. 

Pfister F, Carnell LR, Löffler L, Boosz P, Schaft N, Dörrie J, Stein R, Lenz M, Spiecker E, Huber CM, Haddadin S, Berking C, Alexiou C, Janko C.

MedComm (2020). 2025 Jan 5;6(1):e70039. doi: 10.1002/mco2.70039. eCollection 2025 Jan.

PMID: 39764559 Free PMC article. 

CD19-CAR T-cell therapy induces deep tissue depletion of B cells. 

Tur C, Eckstein M, Velden J, Rauber S, Bergmann C, Auth J, Bucci L, Corte G, Hagen M, Wirsching A, Grieshaber-Bouyer R, Reis P, Kittan N, Wacker J, Rius Rigau A, Ramming A, D'Agostino MA, Hartmann A, Müller F, Mackensen A, Bozec A, Schett G, Raimondo MG.

Ann Rheum Dis. 2025 Jan;84(1):106-114. doi: 10.1136/ard-2024-226142. Epub 2025 Jan 2.

PMID: 39874224 

Analyzing Pathophysiology and Immune Cells and Their Cytokines and Mediators in Precision-Cut Slices of the Murine Lung. 

Tatcheff M, Carvalho C, Willar J, Nendel E, Krammer S, Chiriac MT, Zhou S, Geppert CI, Finotto S.

Curr Protoc. 2025 Jan;5(1):e70087. doi: 10.1002/cpz1.70087.

PMID: 39873159 Free PMC article. 

The Role of Non-coding RNAs in Tumorigenesis, Diagnosis/Prognosis, and Therapeutic Strategies for Cutaneous Melanoma. 

Schaft N, Dörrie J.

Methods Mol Biol. 2025;2883:79-107. doi: 10.1007/978-1-0716-4290-0_4.

PMID: 39702705 Review.

Improved survival of advanced melanoma patients receiving immunotherapy with concomitant antithrombotic therapy - A multicenter study on 2419 patients from the prospective skin cancer registry ADOReg. 

Kött J, Zell T, Zimmermann N, Rünger A, Smit DJ, Abeck F, Geidel G, Hansen-Abeck I, Heidrich I, Weichenthal M, Ugurel S, Leiter U, Berking C, Gutzmer R, Schadendorf D, Zimmer L, Livingstone E, Wasielewski IV, Mohr P, Meier F, Haferkamp S, Drexler K, Herbst R, Kellner I, Utikal J, Wohlfeil SA, Pföhler C, Adam L, Terheyden P, Ulrich J, Meiss F, Möbes M, Welzel J, Schilling B, Ziller F, Kaatz M, Kreuter A, Sindrilaru A, Dippel E, Sachse M, Weishaupt C, Hüning S, Heinzerling L, Loquai C, Schley G, Gambichler T, Löffler H, Grabbe S, Schultz E, Devereux N, Hassel JC, Simon JC, Raap U, Assaf C, Klemke CD, Sunderkötter C, Hofmann SC, Wenk S, Tronnier M, Thies S, Heppt MV, Eggermont A, Schulze HJ, Zouboulis CC, Tüting T, Bauer AT, Schneider SW, Gebhardt C.

Eur J Cancer. 2025 Jan;214:115159. doi: 10.1016/j.ejca.2024.115159. Epub 2024 Nov 30.

PMID: 39642845 

Metabolic rewiring controlled by HIF-1α tunes IgA-producing B-cell differentiation and intestinal inflammation. 

Meng X, Asadi-Asadabad S, Cao S, Song R, Lin Z, Safhi M, Qin Y, Tcheumi Tactoum E, Taudte V, Ekici A, Mielenz D, Wirtz S, Schett G, Bozec A.

Cell Mol Immunol. 2025 Jan;22(1):54-67. doi: 10.1038/s41423-024-01233-y. Epub 2024 Nov 14.

PMID: 39543372 Free PMC article. 

Intravenous Immunoglobulin Therapy for Pyoderma Gangrenosum: A Multicenter Retrospective Analysis in 81 Patients. 

Ronicke M, Sollfrank L, Vitus MV, Walter LJ, Krieter M, Moelleken M, Dissemond J, Schultz E, Lauffer F, von den Driesch P, Erfurt-Berge C.

Am J Clin Dermatol. 2025 Jan;26(1):139-146. doi: 10.1007/s40257-024-00904-w. Epub 2024 Nov 14.

PMID: 39541069 Free PMC article. 

Molecular Imaging: The New Frontier for Endoscopic Diagnosis and Personalization in Inflammatory Bowel Disease. 

Atreya R, Rath T, Neurath MF.

Gastrointest Endosc Clin N Am. 2025 Jan;35(1):255-263. doi: 10.1016/j.giec.2024.09.002. Epub 2024 Oct 10.

PMID: 39510691 Review.

Relevance of capsule endoscopy in patients with obscure gastrointestinal bleeding - a comprehensive real-world study. 

Vetter M, Gebhardt S, Kessler G, Jesper D, Fischer S, Hagel AF, Siebler J, Konturek PC, Neurath MF, Zopf S.

J Physiol Pharmacol. 2024 Dec;75(6). doi: 10.26402/jpp.2024.6.07. Epub 2025 Feb 3.

PMID: 39923230