Links zu Publikationen 2026

Tools and Advanced Imaging Technologies for Assessing Intestinal Epithelial Barrier Integrity: A Systematic Review. 

Vieujean S, Atreya R, Buda A, Caradec J, Citi S, Danese S, Dewit O, Friedrich M, Ghosh S, Iacucci M, Jairath V, Kaser A, Leong RW, Neurath MF, Pierre N, Pohin M, Rath T, Rivière P, Travis S, Westcott J, Zeissig S, Peyrin-Biroulet L.

Am J Physiol Gastrointest Liver Physiol. 2026 Feb 12. doi: 10.1152/ajpgi.00447.2025. Online ahead of print.

PMID: 41677575      

Reduced serum AHR agonistic activity reflects amyloid dysregulation in AT1 subtypes of Alzheimer's disease. 

Tsaktanis T, Rudtke L, Ammon L, Mestermann S, Rothhammer V, Lewczuk P, Maler JM, Kornhuber J, Oberstein TJ.

Alzheimers Res Ther. 2026 Feb 6. doi: 10.1186/s13195-026-01978-w. Online ahead of print.

PMID: 41652618      No abstract available. 

Harnessing Digital Pathology Tools to Distinguish Hand Eczema From Palmar Psoriasis: A Quantitative Approach. 

Sari M, Schliep S, Petzold A, Kiesewetter F, Erdmann M, Sticherling M, Berking C, Heppt MV, Koch EAT.

J Cutan Pathol. 2026 Feb 5. doi: 10.1111/cup.70064. Online ahead of print.

PMID: 41645409      

Simulation-based inference of cell migration dynamics in complex spatial environments. 

Arruda J, Alamoudi E, Mueller R, Vaisband M, Molkenbur R, Merrin J, Kiermaier E, Hasenauer J.

NPJ Syst Biol Appl. 2026 Jan 29;12(1):20. doi: 10.1038/s41540-026-00648-9.

PMID: 41611727      Free PMC article.      

Repurposing PDE5-Inhibitors: Sildenafil Drives Arteriogenesis via Localized Regenerative Inflammation. 

Elbs K, Bobrowski L, Arnholdt C, Kübler M, Götz P, Rohrmoser MR, Merkus D, Lasch M, Deindl E.

Int J Mol Sci. 2026 Jan 19;27(2):985. doi: 10.3390/ijms27020985.

PMID: 41596630      Free PMC article.      

Molecular stratification and transcriptome-guided therapeutics in systemic lupus erythematosus with insufficient treatment response. 

Beretta L, Chan CWS, Moysidou GS, Nöthling DM, Ainatzoglou A, Zoli A, Katechis S, Fanouriakis A, Bozec A, Sidiropoulos P, Bergmann C, Boumpas DT, Schett G, Bertsias G, Garantziotis P.

J Autoimmun. 2026 Jan 21;159:103525. doi: 10.1016/j.jaut.2026.103525. Online ahead of print.

PMID: 41570368      

Virus-Specific T Cells and Response to Checkpoint Inhibitors in Progressive Multifocal Leukoencephalopathy. 

Möhn N, Grote-Levi L, Bonifacius A, Tischer-Zimmermann S, Nay S, Jendretzky KF, Sassmann ML, Karacondi K, Zent M, Konen FF, Sühs KW, Meuth SG, Pawlitzki M, Warnke C, Ayzenberg I, Schneider R, Helmchen C, Brüggemann N, Klebe S, Hildner M, Grefkes C, Nitsch L, Hühnchen P, Böltz S, Alt L, Tumani H, Kleinschnitz C, Pul R, Grauer O, Clifford D, Gnanapavan S, Wicklein R, Perpoint T, Beudel M, Del Bello A, Rauer S, Wiendl H, Jelcic I, Gasnault J, Cimini E, Antinori A, Pinnetti C, Pourcher V, Weiss N, Lambert N, Maecker-Kolhoff B, Höglinger GU, Zahraeifard S, Cortese I, Eiz-Vesper B, Martin-Blondel G, Skripuletz T; Immunotherapy for PML Study Group.

JAMA Neurol. 2026 Jan 20:e255318. doi: 10.1001/jamaneurol.2025.5318. Online ahead of print.

PMID: 41557340      Free PMC article.      

Contemporary 0.55 T MRI to visualize interstitial lung disease - An exploratory study. 

Bayerl N, Mathy CS, Bergmann C, Bäuerle T, Adams LC, Nagel AM, Distler JHW, Gerhalter T, Uder M, Heiss R, Ellmann S.

Eur J Radiol Open. 2026 Jan 5;16:100720. doi: 10.1016/j.ejro.2025.100720. eCollection 2026 Jun.

PMID: 41550670      Free PMC article.      

Reply to Correspondence on: 'Effects of different B-cell-depleting strategies on the lymphatic tissue'. 

Tur C, Eckstein M, Rauber S, Schett G, Bozec A, Raimondo MG.

Ann Rheum Dis. 2026 Jan;85(1):e1-e2. doi: 10.1016/j.ard.2025.09.008. Epub 2025 Nov 12.

PMID: 41539838      No abstract available. 

A centrally positioned cluster of multiple centrioles in antigen-presenting cells fosters T cell activation. 

Stötzel I, Weier AK, Sarkar A, Som S, Bach L, Konopka P, Miková E, Ghosh S, Böthling J, Homrich M, Schaedel L, Kazmaier U, Symeonidis K, Ebner S, Weidner P, Abdullah Z, Meissner F, Uderhardt S, Hons M, Baumjohann D, Paul R, Rieger H, Kiermaier E.

Nat Commun. 2026 Jan 13;17(1):536. doi: 10.1038/s41467-026-68286-7.

PMID: 41530195      Free PMC article.      

Definition of predictive and prognostic immune biomarkers for salivary gland cancer from the intratumoural and systemic immune status: detailed protocol of the prospective, observatory ImmoGlandula study. 

Donaubauer AJ, Frey B, Agaimy A, Lange F, Mogge L, Fietkau R, Iro H, Munoz LE, Weber M, Kesting M, Gaipl US, Haderlein M, Müller S.

BMJ Open. 2026 Jan 12;16(1):e100021. doi: 10.1136/bmjopen-2025-100021.

PMID: 41526019      Free PMC article.      

Epigenetic Modulation of IL-7 and IL-10: Toward Personalized Immune Therapies in Viral Epidemics. 

Yulugkural Z, Yildiz M, Topcu E, Elmaslar Mert HT, Temiz A.

J Immunol Res. 2026 Jan 8;2026:9467657. doi: 10.1155/jimr/9467657. eCollection 2026.

PMID: 41523740      Free PMC article.      

Intestinal Sclerostin Deficiency Links Gut Dysbiosis to Altered Serotonin Homeostasis in Axial Spondyloarthritis. 

Mauro D, Bergot AS, Guggino G, Salzillo A, Forte G, Ciancio A, Rizzo A, Raimondo S, Lentini L, Gandolfo S, Kim SP, Wong C, De Marino B, Milling S, Alessandro R, Panarese I, Riddle RC, Zaiss MM, McGonagle D, Thomas R, Ciccia F.

Inflammation. 2026 Jan 10;49(1):38. doi: 10.1007/s10753-025-02393-3.

PMID: 41518441      Free PMC article.      

esloco: simulation-based estimation of local coverage in long-read DNA sequencing. 

Weich A, Lischer C, Vera J.

Bioinformatics. 2026 Jan 3;42(2):btag009. doi: 10.1093/bioinformatics/btag009.

PMID: 41512287      Free PMC article.      

Mucosal innate immune activation as the trigger to Prevotella species-induced arthritis in genetically resistant mice. 

Maeda Y, Rabenow M, Xiang W, Schmid E, Otterbein N, Gimaev I, Amend L, Riedinger L, Ehnes L, Miyagawa I, Sarfati I, Lesker TR, Danzer H, Sarter K, Dürholz K, Schälter F, Bao L, Wirtz S, Arnold P, Hofmann J, Pischetsrieder M, Sjöberg D, Svärd A, Kastbom A, Schett G, Strowig T, Zaiss MM.

Cell Rep. 2026 Jan 27;45(1):116755. doi: 10.1016/j.celrep.2025.116755. Epub 2026 Jan 5.

PMID: 41499240      

The role of the TIM-3 receptor in inflammatory bowel disease and autoimmunity: implications for TIM-3 and TCR crosstalk. 

Gabel M, Knauss A, Neurath MF, Weigmann B.

J Mol Med (Berl). 2026 Jan 2;104(1):20. doi: 10.1007/s00109-025-02631-z.

PMID: 41483156      Free PMC article.      Review.      

Skin-derived myeloid precursors and joint-resident fibroblasts spread psoriatic disease from skin to joints. 

Raimondo MG, Mohammadian H, Angeli MR, Alivernini S, Fedorchenko V, Huang K, Demmler R, Rhein P, Xu C, Li YN, Micheroli R, Winter Z, Rigau AR, Anchang CG, Soare A, Luber M, Labinsky H, Chang J, Günther C, Fearon U, Veale DJ, Ciccia F, Rech J, Sticherling M, Bäuerle T, Distler JHW, Kurowska-Stolarska MS, Mack M, Ekici AB, Croft AP, Distler O, Maric HM, Ospelt C, Cañete JD, D'Agostino MA, Schett G, Rauber S, Ramming A.

Nat Immunol. 2026 Jan;27(1):35-47. doi: 10.1038/s41590-025-02351-z. Epub 2026 Jan 2.

PMID: 41482544      Free PMC article.      

T cell engagers emerge as a compelling therapeutic modality. 

Baeuerle PA, Sauer K, Grieshaber-Bouyer R, Michaelson JS.

J Exp Med. 2026 Feb 2;223(2):e20251652. doi: 10.1084/jem.20251652. Epub 2025 Dec 26.

PMID: 41474966      Review.      

Characteristics and quality of life of nine-year survivors with metastatic melanoma treated with pembrolizumab beyond second-line therapy. 

Dugas-Breit S, Forschner A, Erdmann M, Gutzmer R, Kähler KC, Holst I, Brekner A, Franklin C, Sindrilaru A, Zimmer L, Heinzerling L, Utikal J, Meier F, Bender A, Berking C, Garbe C, Weichenthal M, Schadendorf D, Hauschild A, Gschnell M, Mohr P, Hassel JC.

Eur J Cancer. 2026 Jan 17;233:116149. doi: 10.1016/j.ejca.2025.116149. Epub 2025 Nov 29.

PMID: 41385939      

Neutrophil Transmigration Analyses for Multiplexed Drug Screening and In Vivo Like Application Testing Using an Organ on a Chip Model. 

Reichardt CM, Muñoz LE.

Methods Mol Biol. 2026;2990:97-104. doi: 10.1007/978-1-0716-4997-8_8.

PMID: 41269551      

Dual targeting of TNF and IL-23 by a bispecific antibody in ulcerative colitis. 

Atreya R, Neurath MF.

Lancet Gastroenterol Hepatol. 2026 Jan;11(1):5-6. doi: 10.1016/S2468-1253(25)00330-9. Epub 2025 Nov 13.

PMID: 41242335      No abstract available. 

Lifestyle medicine in Parkinson's disease. 

Süß P, Regensburger M, Gassner H, Winkler J.

J Neural Transm (Vienna). 2026 Feb;133(2):279-295. doi: 10.1007/s00702-025-03059-y. Epub 2025 Nov 12.

PMID: 41222709      Free PMC article.      Review.      

Myosin II regulates cellular thermo-adaptability and the efficiency of immune responses. 

Company-Garrido I, Zurita Carpio A, Colomer-Rosell M, Ciraulo B, Molkenbur R, Lanzerstorfer P, Pezzano F, Agazzi C, Hauschild R, Jain S, Jacques JM, Venturini V, Knapp C, Xie Y, Merrin J, Weghuber J, Schaaf M, Quidant R, Kiermaier E, Ortega Arroyo J, Ruprecht V, Wieser S.

Dev Cell. 2026 Feb 11;61(2):356-371.e12. doi: 10.1016/j.devcel.2025.10.006. Epub 2025 Nov 4.

PMID: 41192429      

CAR T-cell therapy in systemic sclerosis: the next frontier in immune modulation.  

Garantziotis P, Auth J, Schett G, Bergmann C.

Curr Opin Rheumatol. 2026 Jan 1;38(1):60-68. doi: 10.1097/BOR.0000000000001133. Epub 2025 Oct 30.

PMID: 41185148      Review.      

Entheseal tissue signature in response to IL-17A inhibition in psoriatic arthritis: results from the EBIO entheseal biopsy study. 

Raimondo MG, Mohammadian H, Rauber S, Alivernini S, Fedorchenko V, Rigau AR, Angeli MR, Fagni F, Corte G, Tascilar K, Labinsky H, Ramming AM, Roemer F, Rech J, Braeuer L, D'Agostino MA, Schett G, Pachowsky M, Kleyer A, Ramming A.

Ann Rheum Dis. 2026 Feb;85(2):285-296. doi: 10.1016/j.ard.2025.08.032. Epub 2025 Oct 16.

PMID: 41107119      

Predicting Treatment Outcomes in Patients With Psoriatic Arthritis or Axial Spondyloarthritis: An Artificial Intelligence-Driven Approach. 

Vodenčarević A, Brandt-Juergens J, Bär S, Kästner P, Köhm M, Simon D, Behrens F, Glassen T, Gmeiner B, Peterlik D, Kiltz U.

J Rheumatol. 2026 Feb 1;53(2):152-161. doi: 10.3899/jrheum.2025-0327.

PMID: 41093647      

[Amniotic membrane-covered bioimplants for treatment of severe pseudomembranous keratoconjunctivitis in two patients with erythema exsudativum multiforme following pneumonia caused by Mycoplasma pneumoniae]. 

Voulgari T, Heppt MV, Steinhorst K, Kruse FE, Weller JM.

Ophthalmologie. 2026 Jan;123(1):67-70. doi: 10.1007/s00347-025-02317-4. Epub 2025 Aug 29.

PMID: 40879749      German.      No abstract available. 

Safety, tolerability, pharmacokinetics and pharmacodynamic effects of desmoglein 3 peptide-coupled tolerizing nanoparticles in pemphigus. 

Didona D, Hudemann C, Garn H, Krzikalla D, Wang SH, Hinterseher J, Volkmann K, Polakova A, Zakrzewicz A, Feldhoff S, Tikkanen R, Digigow R, Pfützner W, Santos A, Zimmer CL, Hahmann M, Harnisch S, Rösch S, Huguenin S, Eming R, Hahn M, Schauer F, Antiga E, Senatore S, Maglie R, Täubel J, Ghoreschi K, Meier K, Solimani F, Sticherling M, Sollfrank L, Günther C, Steinbrink K, Magnolo N, van Schaick E, Asnaghi V, Zollmann FS, Pohlner J, Hummel J, Sandbrink R, de Min C, Fleischer S, Möbs C, Hertl M.

Br J Dermatol. 2026 Jan 6;194(1):86-98. doi: 10.1093/bjd/ljaf311.

PMID: 40795222      Clinical Trial.      

Differential molecular signatures in response to CD19-CAR T cell therapy compared with conventional pharmacotherapy in systemic lupus erythematosus. 

Garantziotis P, Beretta L, Lindblom J, Moysidou GS, Nikolopoulos D, Grieshaber-Bouyer R, Hagen M, Bergmann C, Wirsching A, Bozec A; PRECISESADS Clinical Consortium; Schneider M, Barturen G, Bertsias G, Boumpas DT, Alarcón-Riquelme ME, Mackensen A, Schett G, Parodis I.

Ann Rheum Dis. 2026 Jan;85(1):153-163. doi: 10.1016/j.ard.2025.06.2132. Epub 2025 Jul 23.

PMID: 40701862      

Calibration-free Laser-induced Breakdown Spectroscopy (CF-LIBS): Plasma criteria for porcine tissue. 

Böhmer E, Degelmann LS, Thoma OM, Waldner MJ, Mehari F, Klämpfl F, Hohmann M, Schmidt M.

Talanta. 2026 Jan 1;297(Pt A):128545. doi: 10.1016/j.talanta.2025.128545. Epub 2025 Jul 15.

PMID: 40680366      

Deep learning-based classification of erosion, synovitis and osteitis in hand MRI of patients with inflammatory arthritis. 

Schlereth M, Mutlu MY, Utz J, Bayat S, Heimann T, Qiu J, Ehring C, Liu C, Uder M, Kleyer A, Simon D, Roemer F, Schett G, Breininger K, Fagni F.

RMD Open. 2024 Jun 17;10(2):e004273. doi: 10.1136/rmdopen-2024-004273.

PMID: 38886001      Free PMC article.      

Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids. 

Auger JP, Zimmermann M, Faas M, Stifel U, Chambers D, Krishnacoumar B, Taudte RV, Grund C, Erdmann G, Scholtysek C, Uderhardt S, Ben Brahim O, Pascual Maté M, Stoll C, Böttcher M, Palumbo-Zerr K, Mangan MSJ, Dzamukova M, Kieler M, Hofmann M, Blüml S, Schabbauer G, Mougiakakos D, Sonnewald U, Hartmann F, Simon D, Kleyer A, Grüneboom A, Finotto S, Latz E, Hofmann J, Schett G, Tuckermann J, Krönke G.

Nature. 2024 May;629(8010):184-192. doi: 10.1038/s41586-024-07282-7. Epub 2024 Apr 10.

PMID: 38600378      

Physical Function of RA patients Tapering Treatment-A Post Hoc Analysis of the Randomized Controlled RETRO Trial. 

Stephan M, Tascilar K, Yalcin-Mutlu M, Hagen M, Haschka J, Reiser M, Hartmann F, Kleyer A, Hueber AJ, Manger B, Figueiredo C, Cobra JF, Tony HP, Finzel S, Kleinert S, Wendler J, Schuch F, Ronneberger M, Feuchtenberger M, Fleck M, Manger K, Ochs W, Schmitt-Haendle M, Lorenz HM, Nüsslein H, Alten R, Henes J, Krüger K, Schett G, Rech J.

J Clin Med. 2023 May 28;12(11):3723. doi: 10.3390/jcm12113723.

PMID: 37297917      Free PMC article.      

Author Correction: Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus.  

Mackensen A, Müller F, Mougiakakos D, Böltz S, Wilhelm A, Aigner M, Völkl S, Simon D, Kleyer A, Munoz L, Kretschmann S, Kharboutli S, Gary R, Reimann H, Rösler W, Uderhardt S, Bang H, Herrmann M, Ekici AB, Buettner C, Habenicht KM, Winkler TH, Krönke G, Schett G.

Nat Med. 2023 Nov;29(11):2956. doi: 10.1038/s41591-022-02091-9.

PMID: 36329355      No abstract available. 

Diagnostic delay stages and pre-diagnostic treatment in patients with suspected rheumatic diseases before special care consultation: results of a multicenter-based study. 

Fuchs F, Morf H, Mohn J, Mühlensiepen F, Ignatyev Y, Bohr D, Araujo E, Bergmann C, Simon D, Kleyer A, Vorbrüggen W, Ramming A, Distler JHW, Bartz-Bazzanella P, Schett G, Welcker M, Hueber AJ, Knitza J.

Rheumatol Int. 2023 Mar;43(3):495-502. doi: 10.1007/s00296-022-05223-z. Epub 2022 Oct 10.

PMID: 36214864      Free PMC article.      

Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus. 

Mackensen A, Müller F, Mougiakakos D, Böltz S, Wilhelm A, Aigner M, Völkl S, Simon D, Kleyer A, Munoz L, Kretschmann S, Kharboutli S, Gary R, Reimann H, Rösler W, Uderhardt S, Bang H, Herrmann M, Ekici AB, Buettner C, Habenicht KM, Winkler TH, Krönke G, Schett G.

Nat Med. 2022 Oct;28(10):2124-2132. doi: 10.1038/s41591-022-02017-5. Epub 2022 Sep 15.

PMID: 36109639      

Comparison of physician and artificial intelligence-based symptom checker diagnostic accuracy. 

Gräf M, Knitza J, Leipe J, Krusche M, Welcker M, Kuhn S, Mucke J, Hueber AJ, Hornig J, Klemm P, Kleinert S, Aries P, Vuillerme N, Simon D, Kleyer A, Schett G, Callhoff J.

Rheumatol Int. 2022 Dec;42(12):2167-2176. doi: 10.1007/s00296-022-05202-4. Epub 2022 Sep 10.

PMID: 36087130      Free PMC article.      

Effects of casirivimab/imdevimab on systemic and mucosal immunity against SARS-CoV-2 in B-cell depleted patients with autoimmune rheumatic diseases refractory to vaccination. 

Fagni F, Schmidt K, Bohr D, Valor-Méndez L, Hartmann F, Tascilar K, Manger K, Manger B, Kleyer A, Simon D, Schett G, Harrer T.

RMD Open. 2022 May;8(1):e002323. doi: 10.1136/rmdopen-2022-002323.

PMID: 35589333      Free PMC article.      No abstract available. 

Performance of a Handheld Ultrasound Device to Assess Articular and Periarticular Pathologies in Patients with Inflammatory Arthritis. 

Corte G, Bayat S, Tascilar K, Valor-Mendez L, Schuster L, Knitza J, Fagni F, Schett G, Kleyer A, Simon D.

Diagnostics (Basel). 2021 Jun 22;11(7):1139. doi: 10.3390/diagnostics11071139.

PMID: 34206675      Free PMC article.      

Patients with immune-mediated inflammatory diseases receiving cytokine inhibitors have low prevalence of SARS-CoV-2 seroconversion. 

Simon D, Tascilar K, Krönke G, Kleyer A, Zaiss MM, Heppt F, Meder C, Atreya R, Klenske E, Dietrich P, Abdullah A, Kliem T, Corte G, Morf H, Leppkes M, Kremer AE, Ramming A, Pachowsky M, Schuch F, Ronneberger M, Kleinert S, Maier C, Hueber AJ, Manger K, Manger B, Berking C, Tenbusch M, Überla K, Sticherling M, Neurath MF, Schett G.

Nat Commun. 2020 Jul 24;11(1):3774. doi: 10.1038/s41467-020-17703-6.

PMID: 32709909      Free PMC article.      

Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis. 

Tajik N, Frech M, Schulz O, Schälter F, Lucas S, Azizov V, Dürholz K, Steffen F, Omata Y, Rings A, Bertog M, Rizzo A, Iljazovic A, Basic M, Kleyer A, Culemann S, Krönke G, Luo Y, Überla K, Gaipl US, Frey B, Strowig T, Sarter K, Bischoff SC, Wirtz S, Cañete JD, Ciccia F, Schett G, Zaiss MM.

Nat Commun. 2020 Apr 24;11(1):1995. doi: 10.1038/s41467-020-15831-7.

PMID: 32332732      Free PMC article.      

JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function. 

Adam S, Simon N, Steffen U, Andes FT, Scholtysek C, Müller DIH, Weidner D, Andreev D, Kleyer A, Culemann S, Hahn M, Schett G, Krönke G, Frey S, Hueber AJ.

Sci Transl Med. 2020 Feb 12;12(530):eaay4447. doi: 10.1126/scitranslmed.aay4447.

PMID: 32051226