Links zu Publikationen 2024

Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids. 

Auger JP, Zimmermann M, Faas M, Stifel U, Chambers D, Krishnacoumar B, Taudte RV, Grund C, Erdmann G, Scholtysek C, Uderhardt S, Ben Brahim O, Pascual Maté M, Stoll C, Böttcher M, Palumbo-Zerr K, Mangan MSJ, Dzamukova M, Kieler M, Hofmann M, Blüml S, Schabbauer G, Mougiakakos D, Sonnewald U, Hartmann F, Simon D, Kleyer A, Grüneboom A, Finotto S, Latz E, Hofmann J, Schett G, Tuckermann J, Krönke G.

Nature. 2024 May;629(8010):184-192. doi: 10.1038/s41586-024-07282-7. Epub 2024 Apr 10.

PMID: 38600378 

Bispecific T cell engager therapy for refractory rheumatoid arthritis. 

Bucci L, Hagen M, Rothe T, Raimondo MG, Fagni F, Tur C, Wirsching A, Wacker J, Wilhelm A, Auger JP, Pachowsky M, Eckstein M, Alivernini S, Zoli A, Krönke G, Uderhardt S, Bozec A, D'Agostino MA, Schett G, Grieshaber-Bouyer R.

Nat Med. 2024 Jun;30(6):1593-1601. doi: 10.1038/s41591-024-02964-1. Epub 2024 Apr 26.

PMID: 38671240 

Strategies for targeting cytokines in inflammatory bowel disease. 

Neurath MF.

Nat Rev Immunol. 2024 Aug;24(8):559-576. doi: 10.1038/s41577-024-01008-6. Epub 2024 Mar 14.

PMID: 38486124 Review.

L-arginine metabolism inhibits arthritis and inflammatory bone loss. 

Cao S, Li Y, Song R, Meng X, Fuchs M, Liang C, Kachler K, Meng X, Wen J, Schlötzer-Schrehardt U, Taudte V, Gessner A, Kunz M, Schleicher U, Zaiss MM, Kastbom A, Chen X, Schett G, Bozec A.

Ann Rheum Dis. 2024 Jan 2;83(1):72-87. doi: 10.1136/ard-2022-223626.

PMID: 37775153 Free PMC article. 

Biomarkers for Personalizing IBD Therapy: The Quest Continues. 

Atreya R, Neurath MF.

Clin Gastroenterol Hepatol. 2024 Jul;22(7):1353-1364. doi: 10.1016/j.cgh.2024.01.026. Epub 2024 Feb 4.

PMID: 38320679 Review.

CD200⁺ fibroblasts form a pro-resolving mesenchymal network in arthritis. 

Rauber S, Mohammadian H, Schmidkonz C, Atzinger A, Soare A, Treutlein C, Kemble S, Mahony CB, Geisthoff M, Angeli MR, Raimondo MG, Xu C, Yang KT, Lu L, Labinsky H, Saad MSA, Gwellem CA, Chang J, Huang K, Kampylafka E, Knitza J, Bilyy R, Distler JHW, Hanlon MM, Fearon U, Veale DJ, Roemer FW, Bäuerle T, Maric HM, Maschauer S, Ekici AB, Buckley CD, Croft AP, Kuwert T, Prante O, Cañete JD, Schett G, Ramming A.

Nat Immunol. 2024 Apr;25(4):682-692. doi: 10.1038/s41590-024-01774-4. Epub 2024 Feb 23.

PMID: 38396288 

B cell-targeting chimeric antigen receptor T cells as an emerging therapy in neuroimmunological diseases. 

Haghikia A, Schett G, Mougiakakos D.

Lancet Neurol. 2024 Jun;23(6):615-624. doi: 10.1016/S1474-4422(24)00140-6.

PMID: 38760099 Review.

Targeting cytokines in psoriatic arthritis. 

Neurath L, Sticherling M, Schett G, Fagni F.

Cytokine Growth Factor Rev. 2024 Aug;78:1-13. doi: 10.1016/j.cytogfr.2024.06.001. Epub 2024 Jul 23.

PMID: 39068140 Review.

Collection on clinical photoacoustic imaging. 

Vonk J, Knieling F, Kruijff S.

Eur J Nucl Med Mol Imaging. 2024 Sep;51(11):3151-3152. doi: 10.1007/s00259-024-06780-0.

PMID: 38832946 No abstract available. 

IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling. 

Chiriac MT, Hracsko Z, Günther C, Gonzalez-Acera M, Atreya R, Stolzer I, Wittner L, Dressel A, Schickedanz L, Gamez-Belmonte R, Erkert L, Hundorfean G, Zundler S, Rath T, Vetrano S, Danese S, Sturm G, Trajanoski Z, Kühl AA, Siegmund B, Hartmann A, Wirtz S, Siebler J, Finotto S, Becker C, Neurath MF.

Gut. 2024 Jan 5;73(2):282-297. doi: 10.1136/gutjnl-2023-329628.

PMID: 37884352 Free PMC article. 

Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase. 

Andreev D, Kachler K, Liu M, Chen Z, Krishnacoumar B, Ringer M, Frey S, Krönke G, Voehringer D, Schett G, Bozec A.

Nat Commun. 2024 Feb 5;15(1):1067. doi: 10.1038/s41467-024-45261-8.

PMID: 38316791 Free PMC article. 

The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology. 

Linnerbauer M, Lößlein L, Vandrey O, Peter A, Han Y, Tsaktanis T, Wogram E, Needhamsen M, Kular L, Nagel L, Zissler J, Andert M, Meszaros L, Hanspach J, Zuber F, Naumann UJ, Diebold M, Wheeler MA, Beyer T, Nirschl L, Cirac A, Laun FB, Günther C, Winkler J, Bäuerle T, Jagodic M, Hemmer B, Prinz M, Quintana FJ, Rothhammer V.

Nat Immunol. 2024 Mar;25(3):432-447. doi: 10.1038/s41590-024-01756-6. Epub 2024 Feb 26.

PMID: 38409259 Free PMC article. 

CD19-CAR T-cell therapy induces deep tissue depletion of B cells. 

Tur C, Eckstein M, Velden J, Rauber S, Bergmann C, Auth J, Bucci L, Corte G, Hagen M, Wirsching A, Grieshaber-Bouyer R, Reis P, Kittan N, Wacker J, Rius Rigau A, Ramming A, D'Agostino MA, Hartmann A, Müller F, Mackensen A, Bozec A, Schett G, Raimondo MG.

Ann Rheum Dis. 2024 Sep 11:ard-2024-226142. doi: 10.1136/ard-2024-226142. Online ahead of print.

PMID: 39153835 

European Neuroendocrine Tumor Society (ENETS) 2024 guidance paper for the management of well-differentiated small intestine neuroendocrine tumours. 

Lamarca A, Bartsch DK, Caplin M, Kos-Kudla B, Kjaer A, Partelli S, Rinke A, Janson ET, Thirlwell C, van Velthuysen MF, Vullierme MP, Pavel M.

J Neuroendocrinol. 2024 Sep;36(9):e13423. doi: 10.1111/jne.13423. Epub 2024 Jul 8.

PMID: 38977327 

Alzheimer's disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis. 

Erkert L, Gamez-Belmonte R, Kabisch M, Schödel L, Patankar JV, Gonzalez-Acera M, Mahapatro M, Bao LL, Plattner C, Kühl AA, Shen J, Serneels L, De Strooper B; TRR241 IBDome Consortium; Neurath MF, Wirtz S, Becker C.

Gut. 2024 Sep 9;73(10):1618-1631. doi: 10.1136/gutjnl-2023-331622.

PMID: 38684238 

Acod1-mediated inhibition of aerobic glycolysis suppresses osteoclast differentiation and attenuates bone erosion in arthritis. 

Kachler K, Andreev D, Thapa S, Royzman D, Gießl A, Karuppusamy S, Llerins Perez M, Liu M, Hofmann J, Gessner A, Meng X, Rauber S, Steinkasserer A, Fromm M, Schett G, Bozec A.

Ann Rheum Dis. 2024 Nov 14;83(12):1691-1706. doi: 10.1136/ard-2023-224774.

PMID: 38964754 

Clinical efficacy and autoantibody seroconversion with CD19-CAR T cell therapy in a patient with rheumatoid arthritis and coexisting myasthenia gravis. 

Haghikia A, Hegelmaier T, Wolleschak D, Böttcher M, Pappa V, Motte J, Borie D, Gold R, Feist E, Schett G, Mougiakakos D.

Ann Rheum Dis. 2024 Oct 21;83(11):1597-1598. doi: 10.1136/ard-2024-226017.

PMID: 38937071 No abstract available. 

Neutrophil extracellular traps characterize caseating granulomas. 

Zlatar L, Knopf J, Singh J, Wang H, Muñoz-Becerra M, Herrmann I, Chukwuanukwu RC, Eckstein M, Eichhorn P, Rieker RJ, Naschberger E, Burkovski A, Krenn V, Bilyy R, Butova T, Liskina I, Kalabukha I, Khmel O, Boettcher M, Schett G, Butov D, Tkachenko A, Herrmann M.

Cell Death Dis. 2024 Jul 31;15(7):548. doi: 10.1038/s41419-024-06892-3.

PMID: 39085192 Free PMC article. 

Identifying biomarkers and novel therapeutic targets in uveal melanoma. 

Wessely A, Koch EAT, Vera J, Berking C, Heppt MV.

J Dtsch Dermatol Ges. 2024 Jan;22(1):29-32. doi: 10.1111/ddg.15225. Epub 2023 Oct 30.

PMID: 37902386 Review.

Type 1 Autoimmune Pancreatitis in Europe: Clinical Profile and Response to Treatment. 

Overbeek KA, Poulsen JL, Lanzillotta M, Vinge-Holmquist O, Macinga P, Demirci AF, Sindhunata DP, Backhus J, Algül H, Buijs J, Levy P, Kiriukova M, Goni E, Hollenbach M, Miksch RC, Kunovsky L, Vujasinovic M, Nikolic S, Dickerson L, Hirth M, Neurath MF, Zumblick M, Vila J, Jalal M, Beyer G, Frost F, Carrara S, Kala Z, Jabandziev P, Sisman G, Akyuz F, Capurso G, Falconi M, Arlt A, Vleggaar FP, Barresi L, Greenhalf B, Czakó L, Hegyi P, Hopper A, Nayar MK, Gress TM, Vitali F, Schneider A, Halloran CM, Trna J, Okhlobystin AV, Dagna L, Cahen DL, Bordin D, Rebours V, Mayerle J, Kahraman A, Rasch S, Culver E, Kleger A, Martínez-Moneo E, Røkke O, Hucl T, Olesen SS, Bruno MJ, Della-Torre E, Beuers U, Löhr JM, Rosendahl J; PrescrAIP Study Group.

Clin Gastroenterol Hepatol. 2024 May;22(5):994-1004.e10. doi: 10.1016/j.cgh.2023.12.010. Epub 2024 Jan 5.

PMID: 38184096 

Tumor Antigens beyond the Human Exome. 

Emilius L, Bremm F, Binder AK, Schaft N, Dörrie J.

Int J Mol Sci. 2024 Apr 25;25(9):4673. doi: 10.3390/ijms25094673.

PMID: 38731892 Free PMC article. Review.

[CAR T-cell therapy in rheumatology-What we know so far?]. 

Hagen M, Wirsching A, Bohr D, Taubmann J, Müller F, Mackensen A, Grieshaber-Bouyer R, Schett G.

Z Rheumatol. 2024 Aug;83(6):485-491. doi: 10.1007/s00393-024-01514-x. Epub 2024 May 23.

PMID: 38780637 Free PMC article. Review.German. 

Neuroinflammatory disease signatures in SPG11-related hereditary spastic paraplegia patients. 

Krumm L, Pozner T, Zagha N, Coras R, Arnold P, Tsaktanis T, Scherpelz K, Davis MY, Kaindl J, Stolzer I, Süß P, Khundadze M, Hübner CA, Riemenschneider MJ, Baets J, Günther C, Jayadev S, Rothhammer V, Krach F, Winkler J, Winner B, Regensburger M.

Acta Neuropathol. 2024 Feb 2;147(1):28. doi: 10.1007/s00401-023-02675-w.

PMID: 38305941 Free PMC article. 

Fully Human Anti-CD19 CAR T Cells Derived from Systemic Lupus Erythematosus Patients Exhibit Cytotoxicity with Reduced Inflammatory Cytokine Production. 

Dingfelder J, Aigner M, Taubmann J, Minopoulou I, Park S, Kaplan CD, Cheng JK, Van Blarcom T, Schett G, Mackensen A, Lutzny-Geier G.

Transplant Cell Ther. 2024 Jun;30(6):582.e1-582.e10. doi: 10.1016/j.jtct.2024.03.023. Epub 2024 Mar 26.

PMID: 38548226 

ATP citrate lyase (ACLY)-dependent immunometabolism in mucosal T cells drives experimental colitis in vivo. 

Schulz-Kuhnt A, Rühle K, Javidmehr A, Döbrönti M, Biwank J, Knittel S, Neidlinger P, Leupold J, Liu LJ, Dedden M, Taudte RV, Gessner A, Fromm MF, Mielenz D, Kreiss L, Waldner MJ, Schürmann S, Friedrich O, Dietel B, López-Posadas R, Plattner C; TRR241 IBDome Consortium; Zundler S, Becker C, Atreya R, Neurath MF, Atreya I.

Gut. 2024 Mar 7;73(4):601-612. doi: 10.1136/gutjnl-2023-330543.

PMID: 38176897 

Metabolic and molecular imaging in inflammatory arthritis. 

Noversa de Sousa R, Tascilar K, Corte G, Atzinger A, Minopoulou I, Ohrndorf S, Waldner M, Schmidkonz C, Kuwert T, Knieling F, Kleyer A, Ramming A, Schett G, Simon D, Fagni F.

RMD Open. 2024 Feb 9;10(1):e003880. doi: 10.1136/rmdopen-2023-003880.

PMID: 38341194 Free PMC article. Review.

Preclinical Development of CAR T Cells with Antigen-Inducible IL18 Enforcement to Treat GD2-Positive Solid Cancers. 

Fischer-Riepe L, Kailayangiri S, Zimmermann K, Pfeifer R, Aigner M, Altvater B, Kretschmann S, Völkl S, Hartley J, Dreger C, Petry K, Bosio A, von Döllen A, Hartmann W, Lode H, Görlich D, Mackensen A, Jungblut M, Schambach A, Abken H, Rossig C.

Clin Cancer Res. 2024 Aug 15;30(16):3564-3577. doi: 10.1158/1078-0432.CCR-23-3157.

PMID: 38593230 

Attenuation of fibroblast activation and fibrosis by adropin in systemic sclerosis. 

Liang M, Dickel N, Györfi AH, SafakTümerdem B, Li YN, Rigau AR, Liang C, Hong X, Shen L, Matei AE, Trinh-Minh T, Tran-Manh C, Zhou X, Zehender A, Kreuter A, Zou H, Schett G, Kunz M, Distler JHW.

Sci Transl Med. 2024 Mar 27;16(740):eadd6570. doi: 10.1126/scitranslmed.add6570. Epub 2024 Mar 27.

PMID: 38536934 

Osteocytes support bone metastasis of melanoma cells by CXCL5. 

Jia Y, Zhang F, Meng X, Andreev D, Lyu P, Zhang W, Lai C, Schett G, Bozec A.

Cancer Lett. 2024 May 28;590:216866. doi: 10.1016/j.canlet.2024.216866. Epub 2024 Apr 6.

PMID: 38589005 

Cytokines in gingivitis and periodontitis: from pathogenesis to therapeutic targets. 

Neurath N, Kesting M.

Front Immunol. 2024 Aug 26;15:1435054. doi: 10.3389/fimmu.2024.1435054. eCollection 2024.

PMID: 39253090 Free PMC article. Review.

Editorial: Autoantibodies for diagnostics, prognostics, and surveillance in autoimmune disease. 

Enocsson H, Lundberg IE, Herrmann M, Parodis I, Sjöwall C.

Front Med (Lausanne). 2024 Sep 20;11:1491035. doi: 10.3389/fmed.2024.1491035. eCollection 2024.

PMID: 39371347 Free PMC article. No abstract available. 

Cellular immunotherapies and immune cell depleting therapies in inflammatory bowel diseases: the next magic bullet? 

Neurath MF, Sands BE, Rieder F.

Gut. 2024 Jul 17:gutjnl-2024-332919. doi: 10.1136/gutjnl-2024-332919. Online ahead of print.

PMID: 39025492 Review.

2023 EULAR recommendations on imaging in diagnosis and management of crystal-induced arthropathies in clinical practice. 

Mandl P, D'Agostino MA, Navarro-Compán V, Geßl I, Sakellariou G, Abhishek A, Becce F, Dalbeth N, Ea HK, Filippucci E, Hammer HB, Iagnocco A, de Thurah A, Naredo E, Ottaviani S, Pascart T, Pérez-Ruiz F, Pitsillidou IA, Proft F, Rech J, Schmidt WA, Sconfienza LM, Terslev L, Wildner B, Zufferey P, Filippou G.

Ann Rheum Dis. 2024 May 15;83(6):752-759. doi: 10.1136/ard-2023-224771.

PMID: 38320811 Free PMC article. 

Blocking GPR15 Counteracts Integrin-dependent T Cell Gut Homing in Vivo. 

Schramm S, Liu LJ, Saad M, Dietz L, Dedden M, Müller TM, Atreya I, Voskens CJ, Atreya R, Neurath MF, Zundler S.

J Crohns Colitis. 2024 Aug 6;18(7):1162-1172. doi: 10.1093/ecco-jcc/jjae012.

PMID: 38243565 

Caspase-8 promotes scramblase-mediated phosphatidylserine exposure and fusion of osteoclast precursors. 

Krishnacoumar B, Stenzel M, Garibagaoglu H, Omata Y, Sworn RL, Hofmann T, Ipseiz N, Czubala MA, Steffen U, Maccataio A, Stoll C, Böhm C, Herrmann M, Uderhardt S, Jenkins RH, Taylor PR, Grüneboom A, Zaiss MM, Schett G, Krönke G, Scholtysek C.

Bone Res. 2024 Jul 11;12(1):40. doi: 10.1038/s41413-024-00338-4.

PMID: 38987568 Free PMC article. 

Double-edged sword: Alcohol's effect on rheumatoid arthritis and beyond. 

Hübner M, Zaiss MM, Azizov V.

Joint Bone Spine. 2024 Jan;91(1):105626. doi: 10.1016/j.jbspin.2023.105626. Epub 2023 Aug 4.

PMID: 37543136 No abstract available. 

Linking IL-10 signaling with lipid metabolic programs in macrophages: dysregulated ceramide homeostasis drives colitis. 

Atreya I, Neurath MF.

Signal Transduct Target Ther. 2024 Jun 8;9(1):156. doi: 10.1038/s41392-024-01864-7.

PMID: 38851767 Free PMC article. No abstract available. 

NLRP3 Inhibition Leads to Impaired Mucosal Fibroblast Function in Patients with Inflammatory Bowel Diseases. 

Weber S, Sitte S, Voegele AL, Sologub L, Wilfer A, Rath T, Nägel A, Zundler S, Franchi L, Opipari AW, Sonnewald S, Reid S, Hartmann A, Eichhorn P, Handtrack C, Weber K, Grützmann R, Neufert C, Schellerer VS, Naschberger E, Ekici AB, Büttner C, Neurath MF, Atreya R.

J Crohns Colitis. 2024 Mar 1;18(3):446-461. doi: 10.1093/ecco-jcc/jjad164.

PMID: 37748021 

Clec12A, CD301b, and FcγRIIB/III define the heterogeneity of murine DC2s and DC3s. 

Amon L, Seichter A, Vurnek D, Heger L, Lächele L, Tochoedo NR, Kaszubowski T, Hatscher L, Baranska A, Tchitashvili G, Nimmerjahn F, Lehmann CHK, Dudziak D.

Cell Rep. 2024 Mar 26;43(3):113949. doi: 10.1016/j.celrep.2024.113949. Epub 2024 Mar 14.

PMID: 38492222 

Effects of tofersen treatment in patients with SOD1-ALS in a "real-world" setting - a 12-month multicenter cohort study from the German early access program. 

Wiesenfarth M, Dorst J, Brenner D, Elmas Z, Parlak Ö, Uzelac Z, Kandler K, Mayer K, Weiland U, Herrmann C, Schuster J, Freischmidt A, Müller K, Siebert R, Bachhuber F, Simak T, Günther K, Fröhlich E, Knehr A, Regensburger M, German A, Petri S, Grosskreutz J, Klopstock T, Reilich P, Schöberl F, Hagenacker T, Weyen U, Günther R, Vidovic M, Jentsch M, Haarmeier T, Weydt P, Valkadinov I, Hesebeck-Brinckmann J, Conrad J, Weishaupt JH, Schumann P, Körtvélyessy P, Meyer T, Ruf WP, Witzel S, Senel M, Tumani H, Ludolph AC.

EClinicalMedicine. 2024 Feb 15;69:102495. doi: 10.1016/j.eclinm.2024.102495. eCollection 2024 Mar.

PMID: 38384337 Free PMC article. 

Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity. 

Hansen MS, Madsen K, Price M, Søe K, Omata Y, Zaiss MM, Gorvin CM, Frost M, Rauch A.

Bone Res. 2024 Jan 24;12(1):5. doi: 10.1038/s41413-023-00312-6.

PMID: 38263167 Free PMC article. 

The Current State of Systemic Therapy of Metastatic Uveal Melanoma. 

Koch EAT, Heppt MV, Berking C.

Am J Clin Dermatol. 2024 Sep;25(5):691-700. doi: 10.1007/s40257-024-00872-1. Epub 2024 Jun 22.

PMID: 38907174 Free PMC article. Review.

Multispectral optoacoustic tomography enables assessment of disease activity in paediatric inflammatory bowel disease. 

Regensburger AP, Eckstein M, Wetzl M, Raming R, Paulus LP, Buehler A, Nedoschill E, Danko V, Jüngert J, Wagner AL, Schnell A, Rückel A, Rother U, Rompel O, Uder M, Hartmann A, Neurath MF, Woelfle J, Waldner MJ, Hoerning A, Knieling F.

Photoacoustics. 2023 Dec 1;35:100578. doi: 10.1016/j.pacs.2023.100578. eCollection 2024 Feb.

PMID: 38144890 Free PMC article. 

Teachability of multispectral optoacoustic tomography. 

Li Y, Gröhl J, Haney B, Caranovic M, Lorenz-Meyer E, Papatheodorou N, Kempf J, Regensburger AP, Nedoschill E, Buehler A, Siebenlist G, Lang W, Uder M, Neurath MF, Waldner M, Knieling F, Rother U.

J Biophotonics. 2024 Jul;17(7):e202400106. doi: 10.1002/jbio.202400106. Epub 2024 May 8.

PMID: 38719459 

Fetal liver macrophages contribute to the hematopoietic stem cell niche by controlling granulopoiesis. 

Kayvanjoo AH, Splichalova I, Bejarano DA, Huang H, Mauel K, Makdissi N, Heider D, Tew HM, Balzer NR, Greto E, Osei-Sarpong C, Baßler K, Schultze JL, Uderhardt S, Kiermaier E, Beyer M, Schlitzer A, Mass E.

Elife. 2024 Mar 25;13:e86493. doi: 10.7554/eLife.86493.

PMID: 38526524 Free PMC article. 

Clinical characterization of common pathogenic variants of SOD1-ALS in Germany. 

Wiesenfarth M, Forouhideh-Wiesenfarth Y, Elmas Z, Parlak Ö, Weiland U, Herrmann C, Schuster J, Freischmidt A, Müller K, Siebert R, Günther K, Fröhlich E, Knehr A, Simak T, Bachhuber F, Regensburger M, Petri S, Klopstock T, Reilich P, Schöberl F, Schumann P, Körtvélyessy P, Meyer T, Ruf WP, Witzel S, Tumani H, Brenner D, Dorst J, Ludolph AC.

J Neurol. 2024 Oct;271(10):6667-6679. doi: 10.1007/s00415-024-12564-1. Epub 2024 Aug 14.

PMID: 39141064 Free PMC article. 

Imaging mass cytometry-based characterisation of fibroblast subsets and their cellular niches in systemic sclerosis. 

Rius Rigau A, Liang M, Devakumar V, Neelagar R, Matei AE, Györfi AH, Bergmann C, Filla T, Fedorchenko V, Schett G, Distler JHW, Li YN.

Ann Rheum Dis. 2024 Oct 23:ard-2024-226336. doi: 10.1136/ard-2024-226336. Online ahead of print.

PMID: 39442983 

Functional In Vivo Imaging of Macrophages. 

Wegner A, Palmisano R, Uderhardt S.

Methods Mol Biol. 2024;2713:323-335. doi: 10.1007/978-1-0716-3437-0_22.

PMID: 37639133 

[Update in the diagnosis and treatment of actinic keratosis]. 

Heppt MV.

Dermatologie (Heidelb). 2024 Oct;75(10):815-822. doi: 10.1007/s00105-024-05376-x. Epub 2024 Jul 12.

PMID: 38995371 Review.German. 

p21 Prevents the Exhaustion of CD4⁺ T Cells Within the Antitumor Immune Response Against Colorectal Cancer. 

Thoma OM, Naschberger E, Kubánková M, Larafa I, Kramer V, Menchicchi B, Merkel S, Britzen-Laurent N, Jefremow A, Grützmann R, Koop K, Neufert C, Atreya R, Guck J, Stürzl M, Neurath MF, Waldner MJ.

Gastroenterology. 2024 Feb;166(2):284-297.e11. doi: 10.1053/j.gastro.2023.09.017. Epub 2023 Sep 19.

PMID: 37734420 

Interplay between COVID-19 and Secukinumab treatment in Spondylarthritis patients during the omicron surge: a retrospective cohort study. 

Wu T, Li Y, Huang D, Wu Y, Liang X, Cheng L, Liao Z, Xu F, Chen Y, Zhao J, Xia Z, Tan C, Liu Y, Herrmann M.

Autoimmunity. 2024 Dec;57(1):2281242. doi: 10.1080/08916934.2023.2281242. Epub 2023 Dec 13.

PMID: 38093504 

IL-23R-Specific Chimeric Antigen Receptor Tregs in Crohn's Disease: Dawn of a Cellular Immunotherapeutic Era? 

Atreya R, Neurath MF.

J Crohns Colitis. 2024 Oct 21:jjae159. doi: 10.1093/ecco-jcc/jjae159. Online ahead of print.

PMID: 39432833 No abstract available. 

Anti-inflammatory effects of MerTK by inducing M2 macrophage polarization via PI3K/Akt/GSK-3β pathway in gout. 

Chen F, Li Y, Zhao L, Lin C, Zhou Y, Ye W, Wan W, Zou H, Xue Y.

Int Immunopharmacol. 2024 Dec 5;142(Pt A):112942. doi: 10.1016/j.intimp.2024.112942. Epub 2024 Aug 31.

PMID: 39217874 

Single-cell multi-omics analysis of COVID-19 patients with pre-existing autoimmune diseases shows aberrant immune responses to infection. 

Barmada A, Handfield LF, Godoy-Tena G, de la Calle-Fabregat C, Ciudad L, Arutyunyan A, Andrés-León E, Hoo R, Porter T, Oszlanczi A, Richardson L, Calero-Nieto FJ, Wilson NK, Marchese D, Sancho-Serra C, Carrillo J, Presas-Rodríguez S, Ramo-Tello C, Ruiz-Sanmartin A, Ferrer R, Ruiz-Rodriguez JC, Martínez-Gallo M, Munera-Campos M, Carrascosa JM, Göttgens B, Heyn H, Prigmore E, Casafont-Solé I, Solanich X, Sánchez-Cerrillo I, González-Álvaro I, Raimondo MG, Ramming A, Martin J, Martínez-Cáceres E, Ballestar E, Vento-Tormo R, Rodríguez-Ubreva J.

Eur J Immunol. 2024 Jan;54(1):e2350633. doi: 10.1002/eji.202350633. Epub 2023 Oct 20.

PMID: 37799110 

Late-onset Krabbe disease presenting as spastic paraplegia - implications of GCase and CTSB/D. 

Mächtel R, Dobert JP, Hehr U, Weiss A, Kettwig M, Laugwitz L, Groeschel S, Schmidt M, Arnold P, Regensburger M, Zunke F.

Ann Clin Transl Neurol. 2024 Jul;11(7):1715-1731. doi: 10.1002/acn3.52078. Epub 2024 Jun 4.

PMID: 38837642 Free PMC article. 

Tofersen decreases neurofilament levels supporting the pathogenesis of the SOD1 p.D91A variant in amyotrophic lateral sclerosis patients. 

Weishaupt JH, Körtvélyessy P, Schumann P, Valkadinov I, Weyen U, Hesebeck-Brinckmann J, Weishaupt K, Endres M, Andersen PM, Regensburger M, Dreger M, Koch JC, Conrad J, Meyer T.

Commun Med (Lond). 2024 Jul 25;4(1):150. doi: 10.1038/s43856-024-00573-0.

PMID: 39054363 Free PMC article. 

Tofacitinib Affects M1-like and M2-like Polarization and Tissue Factor Expression in Macrophages of Healthy Donors and IBD Patients. 

Lethen I, Lechner-Grimm K, Gabel M, Knauss A, Atreya R, Neurath MF, Weigmann B.

Inflamm Bowel Dis. 2024 Jul 3;30(7):1151-1163. doi: 10.1093/ibd/izad290.

PMID: 38142236 

Activation and Purification of ß-Glucocerebrosidase by Exploiting its Transporter LIMP-2 - Implications for Novel Treatment Strategies in Gaucher's and Parkinson's Disease. 

Dobert JP, Bub S, Mächtel R, Januliene D, Steger L, Regensburger M, Wilfling S, Chen JX, Dejung M, Plötz S, Hehr U, Moeller A, Arnold P, Zunke F.

Adv Sci (Weinh). 2024 Jul;11(25):e2401641. doi: 10.1002/advs.202401641. Epub 2024 Apr 26.

PMID: 38666485 Free PMC article. 

CCL19-Positive Lymph Node Stromal Cells Govern the Onset of Inflammatory Arthritis via Tropomyosin Receptor Kinase. 

Schälter F, Azizov V, Frech M, Dürholz K, Schmid E, Hendel A, Sarfati I, Maeda Y, Sokolova M, Miyagawa I, Focke K, Sarter K, van Baarsen LGM, Krautwald S, Schett G, Zaiss MM.

Arthritis Rheumatol. 2024 Jun;76(6):857-868. doi: 10.1002/art.42807. Epub 2024 Mar 21.

PMID: 38268500 

Exosomal ROR1 in peritoneal fluid identifies peritoneal disseminated PDAC and is associated with poor survival. 

Mittelstädt A, Anthuber A, David P, Podolska M, Bénard A, Brunner M, Krautz C, Jacobsen A, Denz A, Weber K, Merkel S, Hackner D, Buniatov T, Roßdeutsch L, Klösch B, Swierzy I, Hansen FJ, Strobel D, Zopf Y, Baur JO, Van Deun J, Immanuel Geppert C, Gießl A, Lettmaier S, Semrau S, Grützmann R, Kouhestani D, Weber GF.

Front Immunol. 2024 May 23;15:1253072. doi: 10.3389/fimmu.2024.1253072. eCollection 2024.

PMID: 38846943 Free PMC article. 

Plasma Neurofilaments: Potential Biomarkers of SPG11-Related Hereditary Spastic Paraplegia. 

Krumm L, Winkler J, Winner B, Regensburger M.

Mov Disord. 2024 Apr;39(4):755-757. doi: 10.1002/mds.29755. Epub 2024 Feb 21.

PMID: 38379518 No abstract available. 

Integrin αVß6 - autoantigen and driver of epithelial remodeling in colon and bile ducts in primary sclerosing cholangitis and inflammatory bowel disease. 

Roth D, Düll MM, Horst LJ, Lindemann A, Malzer X, Koop K, Zundler S, Vetter M, Jefremow A, Atreya R, Geppert C, Weidemann S, Waldner MJ, Dietrich P, Günther C, Munoz LE, Herrmann M, Scheffold A, Neurath MF, Siebler J, Schramm C, Kremer AE, Leppkes M.

J Crohns Colitis. 2024 Aug 30:jjae131. doi: 10.1093/ecco-jcc/jjae131. Online ahead of print.

PMID: 39212221 

TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma. 

Gessain G, Anzali AA, Lerousseau M, Mulder K, Bied M, Auperin A, Stockholm D, Signolle N, Sassi F, Marques Da Costa ME, Marchais A, Sayadi A, Weidner D, Uderhardt S, Blampey Q, Nakkireddy SR, Broutin S, Dutertre CA, Busson P, Walter T, Marhic A, Moya-Plana A, Guerlain J, Breuskin I, Casiraghi O, Gorphe P, Classe M, Scoazec JY, Blériot C, Ginhoux F.

Cancer Discov. 2024 Dec 2;14(12):2352-2366. doi: 10.1158/2159-8290.CD-24-0018.

PMID: 39270324 Free PMC article. 

Occlusive cutaneous vasculopathies as cause of chronic ulcers. 

Ronicke M, Berking C, Erfurt-Berge C.

J Dtsch Dermatol Ges. 2024 Apr;22(4):553-567. doi: 10.1111/ddg.15276. Epub 2024 Feb 20.

PMID: 38379266 

Alpha-synuclein fine-tunes neuronal response to pro-inflammatory cytokines. 

Sigutova V, Xiang W, Regensburger M, Winner B, Prots I.

Brain Behav Immun. 2024 Nov;122:216-230. doi: 10.1016/j.bbi.2024.08.015. Epub 2024 Aug 14.

PMID: 39128571 

Vesicular Messages from Dental Biofilms for Neutrophils. 

Vitkov L, Krunić J, Dudek J, Bobbili MR, Grillari J, Hausegger B, Mladenović I, Stojanović N, Krautgartner WD, Oberthaler H, Schauer C, Herrmann M, Singh J, Minnich B, Hannig M.

Int J Mol Sci. 2024 Mar 14;25(6):3314. doi: 10.3390/ijms25063314.

PMID: 38542287 Free PMC article. 

Histological Presentation of Eosinophilic Esophagitis: Simply a Magic Number? 

Sterlacci W, Vieth M, Neurath M.

Inflamm Intest Dis. 2024 Jul 29;9(1):220-228. doi: 10.1159/000540610. eCollection 2024 Jan-Dec.

PMID: 39474332 Free PMC article. Review.

Fiber rich food suppressed airway inflammation, GATA3 + Th2 cells, and FcεRIα+ eosinophils in asthma. 

Schenzel A, Geiger A, Nendel E, Yang Z, Krammer S, Leberle A, Brunst AK, Trump S, Mittler S, Rauh M, Geppert CI, Tausche P, Hohenberger K, Rieker RJ, Schieweck O, Zundler S, Finotto S.

Front Nutr. 2024 May 2;11:1367864. doi: 10.3389/fnut.2024.1367864. eCollection 2024.

PMID: 38757128 Free PMC article. 

Deep learning-based classification of erosion, synovitis and osteitis in hand MRI of patients with inflammatory arthritis. 

Schlereth M, Mutlu MY, Utz J, Bayat S, Heimann T, Qiu J, Ehring C, Liu C, Uder M, Kleyer A, Simon D, Roemer F, Schett G, Breininger K, Fagni F.

RMD Open. 2024 Jun 17;10(2):e004273. doi: 10.1136/rmdopen-2024-004273.

PMID: 38886001 Free PMC article. 

Immobilization by 21 days of bed rest results in type II collagen degradation in healthy individuals. 

Liphardt AM, Godonou ET, Dreiner M, Mündermann A, Tascilar K, Djalal N, Heer M, Schett G, Zaucke F, Niehoff A.

Osteoarthritis Cartilage. 2024 Feb;32(2):177-186. doi: 10.1016/j.joca.2023.11.007. Epub 2023 Nov 19.

PMID: 37989468 

Non-Coding RNA in Tumor Cells and Tumor-Associated Myeloid Cells-Function and Therapeutic Potential. 

Binder AK, Bremm F, Dörrie J, Schaft N.

Int J Mol Sci. 2024 Jul 2;25(13):7275. doi: 10.3390/ijms25137275.

PMID: 39000381 Free PMC article. Review.

Performance of serum biomarkers reflective of different pathogenic processes in systemic sclerosis-associated interstitial lung disease. 

Györfi AH, Filla T, Dickel N, Möller F, Li YN, Bergmann C, Matei AE, Harrer T, Kunz M, Schett G, Distler JHW.

Rheumatology (Oxford). 2024 Apr 2;63(4):962-969. doi: 10.1093/rheumatology/kead332.

PMID: 37421394 

The side effect registry immuno-oncology (SERIO) - A tool for systematic analysis of immunotherapy-induced side effects. 

Ertl C, Ruf T, Mentzer D, Kong M, Kramer R, Bergwelt-Baildon MV, Subklewe M, Tomsitz D, Ascierto PA, Dummer R, Gogas H, Lebbé C, Long GV, McArthur G, Neilan TG, Ribas A, Robert C, Schadendorf D, Zimmer L, Eigentler T, Grabbe S, Forschner A, Kähler KC, Milani V, Pföhler C, Hassel J, Gutzmer R, Loquai C, Routy B, Furness AJS, Blank C, Wolchok JD, French LE, Hauschild A, Heinzerling L.

Eur J Cancer. 2024 Mar;199:113505. doi: 10.1016/j.ejca.2023.113505. Epub 2023 Dec 23.

PMID: 38262306 

Stringent monitoring can decrease mortality of immune checkpoint inhibitor induced cardiotoxicity. 

Wang Y, Ertl C, Schmitt C, Hammann L, Kramer R, Grabmaier U, Schöberl F, Anz D, Piseddu I, Pesch G, Vera J, Froehlich W, Weckbach L, Tomsitz D, Loquai C, Zimmer L, Mangana J, Dummer R, Gutzmer R, Klespe KC, Stege H, Meiss F, Thoms KM, Terheyden P, Bröckelmann PJ, Johnson DB, French LE, Heinzerling L.

Front Cardiovasc Med. 2024 Jun 10;11:1408586. doi: 10.3389/fcvm.2024.1408586. eCollection 2024.

PMID: 38915743 Free PMC article. 

Neutrophils with low production of reactive oxygen species are activated during immune priming and promote development of arthritis. 

Chen T, Zhou Z, Liu Y, Xu J, Zhu C, Sun R, Hu H, Liu Y, Dai L, Holmdahl R, Herrmann M, Zhang L, Muñoz LE, Meng L, Zhao Y.

Redox Biol. 2024 Oct 18;78:103401. doi: 10.1016/j.redox.2024.103401. Online ahead of print.

PMID: 39471640 Free PMC article. 

Neoadjuvant Radiochemotherapy Alters the Immune and Metabolic Microenvironment in Oral Cancer-Analyses of CD68, CD163, TGF-β1, GLUT-1 and HIF-1α Expressions. 

Weber M, Ries J, Braun K, Wehrhan F, Distel L, Geppert C, Lutz R, Kesting M, Trumet L.

Cells. 2024 Feb 25;13(5):397. doi: 10.3390/cells13050397.

PMID: 38474362 Free PMC article. 

Unbiased high-dimensional flow cytometry identified NK and DC immune cell signature in Luminal A-type and triple negative breast cancer. 

Heger L, Heidkamp GF, Amon L, Nimmerjahn F, Bäuerle T, Maier A, Erber R, Hartmann A, Hack CC, Ruebner M, Huebner H, Fasching P, Beckmann MW, Dudziak D.

Oncoimmunology. 2023 Dec 22;13(1):2296713. doi: 10.1080/2162402X.2023.2296713. eCollection 2024.

PMID: 38170155 Free PMC article. 

Anatomical pattern of entheseal and synovial fibroblast activation in patients with psoriasis and its risk of developing psoriatic arthritis. 

Corte G, Atzinger A, Temiz SA, Noversa de Sousa R, Mutlu MY, Schoenau V, Raimondo MG, Kleyer A, Kuwert T, Ramming A, Simon D, Sticherling M, Schmidkonz C, Schett G, Fagni F.

RMD Open. 2024 Jun 11;10(2):e004294. doi: 10.1136/rmdopen-2024-004294.

PMID: 38862244 Free PMC article. 

Ultrasound in Pediatric Inflammatory Bowel Disease-A Review of the State of the Art and Future Perspectives. 

Hoerning A, Jüngert J, Siebenlist G, Knieling F, Regensburger AP.

Children (Basel). 2024 Jan 25;11(2):156. doi: 10.3390/children11020156.

PMID: 38397268 Free PMC article. Review.

Severe bullous pemphigoid in a 4-month-old infant. 

Holtsche MM, van Beek N, Vorobyev A, Schmidt E, Lauten M, Wagner N, Krickau T, Anemüller W.

J Dtsch Dermatol Ges. 2024 Sep;22(9):1279-1281. doi: 10.1111/ddg.15476. Epub 2024 Jul 19.

PMID: 39031519 No abstract available. 

A New Immortalized Human Lacrimal Gland Cell Line. 

Gleixner S, Zahn I, Dietrich J, Singh S, Drobny A, Schneider Y, Schwendner R, Socher E, Blavet N, Bräuer L, Gostian AO, Balk M, Schulze-Tanzil G, Günther C, Paulsen F, Arnold P.

Cells. 2024 Apr 3;13(7):622. doi: 10.3390/cells13070622.

PMID: 38607061 Free PMC article. 

Transferrin receptor 2 mitigates periodontitis-driven alveolar bone loss. 

Lösser L, Ledesma-Colunga MG, Andrés Sastre E, Scholtysek C, Hofbauer LC, Noack B, Baschant U, Rauner M.

J Cell Physiol. 2024 Feb;239(2):e31172. doi: 10.1002/jcp.31172. Epub 2024 Jan 12.

PMID: 38214117 

Preventive effects of early immunosuppressive treatment on the development of interstitial lung disease in systemic sclerosis. 

Velauthapillai A, Bootsma MFR, Bruni C, Bergmann C, Matucci-Cerinic M, Launay D, Riemekastan G, Garzanova L, Airò P, Rezus E, da Silva JAP, Del Galdo F, Hunzelmann N, Chung LS, Krasowska D, Distler O, van den Ende CHM, Vonk MC; EUSTAR collaborators.

Rheumatology (Oxford). 2024 Jul 22:keae375. doi: 10.1093/rheumatology/keae375. Online ahead of print.

PMID: 39037917 

The Role of the Large T Antigen in the Molecular Pathogenesis of Merkel Cell Carcinoma. 

Myrda J, Bremm F, Schaft N, Dörrie J.

Genes (Basel). 2024 Aug 27;15(9):1127. doi: 10.3390/genes15091127.

PMID: 39336718 Free PMC article. Review.

Long-term safety and effectiveness of canakinumab in patients with monogenic autoinflammatory diseases: results from the interim analysis of the RELIANCE registry. 

Kuemmerle-Deschner JB, Kallinich T, Henes J, Kortus-Götze B, Oommen PT, Rech J, Krickau T, Weller-Heinemann F, Horneff G, Janda A, Foeldvari I, Schuetz C, Dressler F, Borte M, Hufnagel M, Meier F, Fiene M, Andreica I, Weber-Arden J, Blank N.

RMD Open. 2024 Feb 15;10(1):e003890. doi: 10.1136/rmdopen-2023-003890.

PMID: 38360038 Free PMC article. 

Metabolic rewiring controlled by HIF-1α tunes IgA-producing B-cell differentiation and intestinal inflammation. 

Meng X, Asadi-Asadabad S, Cao S, Song R, Lin Z, Safhi M, Qin Y, Tcheumi Tactoum E, Taudte V, Ekici A, Mielenz D, Wirtz S, Schett G, Bozec A.

Cell Mol Immunol. 2024 Nov 14. doi: 10.1038/s41423-024-01233-y. Online ahead of print.

PMID: 39543372 

Molecular Imaging: The New Frontier for Endoscopic Diagnosis and Personalization in Inflammatory Bowel Disease. 

Atreya R, Rath T, Neurath MF.

Gastrointest Endosc Clin N Am. 2025 Jan;35(1):255-263. doi: 10.1016/j.giec.2024.09.002. Epub 2024 Oct 10.

PMID: 39510691 Review.

Glowing insights: tracking vedolizumab in the mucosa of patients with IBD via molecular endoscopy. 

Atreya R.

Gut. 2024 Aug 8;73(9):1406-1408. doi: 10.1136/gutjnl-2024-332503.

PMID: 38821860 No abstract available. 

NETworking for Health and in Disease: Neutrophil Extracellular Traps in Pediatric Surgical Care. 

Dölling M, Herrmann M, Boettcher M.

Children (Basel). 2024 Mar 1;11(3):295. doi: 10.3390/children11030295.

PMID: 38539330 Free PMC article. Review.

Treatment trajectories and outcomes in inflammatory bowel disease: a tertiary single-centre experience. 

Wagner K, Müller TM, Vitali F, Fischer S, Haberkamp S, Rouse-Merkel R, Atreya R, Neurath MF, Zundler S.

Therap Adv Gastroenterol. 2024 Sep 28;17:17562848241284051. doi: 10.1177/17562848241284051. eCollection 2024.

PMID: 39381754 Free PMC article. 

Hybrid ultrasound and single wavelength optoacoustic imaging reveals muscle degeneration in peripheral artery disease. 

Träger AP, Günther JS, Raming R, Paulus LP, Lang W, Meyer A, Kempf J, Caranovic M, Li Y, Wagner AL, Tan L, Danko V, Trollmann R, Woelfle J, Klett D, Neurath MF, Regensburger AP, Eckstein M, Uter W, Uder M, Herrmann Y, Waldner MJ, Knieling F, Rother U.

Photoacoustics. 2023 Dec 2;35:100579. doi: 10.1016/j.pacs.2023.100579. eCollection 2024 Feb.

PMID: 38312805 Free PMC article. 

Screening for psoriatic arthritis in dermatological settings-are handheld ultrasound devices the gamechangers we hoped for? 

Bartsch V, Fagni F, Krieter M, Ibrahim M, Temiz SA, Yalcin-Mutlu M, Schett G, Simon D, Hueber AJ.

Rheumatology (Oxford). 2024 Nov 1;63(11):e294-e296. doi: 10.1093/rheumatology/kead592.

PMID: 37935433 No abstract available. 

Calpain-1 weakens the nuclear envelope and promotes the release of neutrophil extracellular traps. 

Singh J, Zlatar L, Muñoz-Becerra M, Lochnit G, Herrmann I, Pfister F, Janko C, Knopf J, Leppkes M, Schoen J, Muñoz LE, Schett G, Herrmann M, Schauer C, Mahajan A.

Cell Commun Signal. 2024 Sep 9;22(1):435. doi: 10.1186/s12964-024-01785-6.

PMID: 39252008 Free PMC article. 

Influence of adjuvant therapies on organ-specific recurrence of cutaneous melanoma: A multicenter study on 1383 patients of the prospective DeCOG registry ADOReg. 

Wohlfeil SA, Kranzmann L, Weiß C, von Wasielewski I, Klespe KC, Kähler KC, Weichenthal M, Schadendorf D, Zimmer L, Mohr P, Meier F, Pfoehler C, Berking C, Heppt MV, Herbst R, Kreuter A, Gutzmer R, Ulrich J, Meiss F, Gebhardt C, Dippel E, Leiter U, Schilling B, Ugurel S, Utikal J.

Int J Cancer. 2024 Nov 15;155(10):1808-1823. doi: 10.1002/ijc.35078. Epub 2024 Jul 8.

PMID: 38975881 

Optimizing immune checkpoint blockade in metastatic uveal melanoma: exploring the association of overall survival and the occurrence of adverse events. 

Koch EAT, Petzold A, Dippel E, Erdmann M, Gesierich A, Gutzmer R, Hassel JC, Haferkamp S, Kähler KC, Kreuzberg N, Leiter U, Loquai C, Meier F, Meissner M, Mohr P, Pföhler C, Rahimi F, Schell B, Terheyden P, Thoms KM, Ugurel S, Ulrich J, Utikal J, Weichenthal M, Ziller F, Berking C, Heppt MV.

Front Immunol. 2024 Jun 10;15:1395225. doi: 10.3389/fimmu.2024.1395225. eCollection 2024.

PMID: 38915414 Free PMC article. 

Metabolic profiling of single cells by exploiting NADH and FAD fluorescence via flow cytometry. 

Abir AH, Weckwerth L, Wilhelm A, Thomas J, Reichardt CM, Munoz L, Völkl S, Appelt U, Mroz M, Niesner R, Hauser A, Sophie Fischer R, Pracht K, Jäck HM, Schett G, Krönke G, Mielenz D.

Mol Metab. 2024 Sep;87:101981. doi: 10.1016/j.molmet.2024.101981. Epub 2024 Jul 4.

PMID: 38971403 Free PMC article. 

Recent advances in nuclear medicine and their role in inflammatory arthritis: focus on the emerging role of FAPI PET/CT. 

Schmidkonz C, Kuwert T, Götz TI, Ramming A, Atzinger A.

Skeletal Radiol. 2024 Nov 25. doi: 10.1007/s00256-024-04834-w. Online ahead of print.

PMID: 39586916 Review.

Efficacy of interventions for cutaneous squamous cell carcinoma in situ (Bowen's disease): A systematic review and meta-analysis of proportions. 

Petzold A, Wessely A, Steeb T, Berking C, Heppt MV.

J Eur Acad Dermatol Venereol. 2024 Aug 16. doi: 10.1111/jdv.20267. Online ahead of print.

PMID: 39148440 Review.

Engineering Therapeutic Regulatory T Cells to Overexpress G Protein-Coupled Receptor 15 Improves Functional Fitness for In Vivo Gut Homing. 

Müller TM, Liu LJ, Wiesinger M; TRR241 Working Group; Neurath MF, Voskens CJ, Zundler S.

Gastroenterology. 2024 Oct 9:S0016-5085(24)05565-3. doi: 10.1053/j.gastro.2024.10.003. Online ahead of print.

PMID: 39389186 No abstract available. 

Diagnostic Accuracy of a Mobile AI-Based Symptom Checker and a Web-Based Self-Referral Tool in Rheumatology: Multicenter Randomized Controlled Trial. 

Knitza J, Tascilar K, Fuchs F, Mohn J, Kuhn S, Bohr D, Muehlensiepen F, Bergmann C, Labinsky H, Morf H, Araujo E, Englbrecht M, Vorbrüggen W, von der Decken CB, Kleinert S, Ramming A, Distler JHW, Bartz-Bazzanella P, Vuillerme N, Schett G, Welcker M, Hueber A.

J Med Internet Res. 2024 Jul 23;26:e55542. doi: 10.2196/55542.

PMID: 39042425 Free PMC article. Clinical Trial. 

Intestinal epithelial Gasdermin C is induced by IL-4R/STAT6 signaling but is dispensable for gut immune homeostasis. 

Gámez-Belmonte R, Wagner Y, Mahapatro M, Wang R, Erkert L, González-Acera M, Cineus R, Hainbuch S, Patankar JV, Voehringer D, Hegazy AN, Neurath MF, Wirtz S, Becker C.

Sci Rep. 2024 Nov 3;14(1):26522. doi: 10.1038/s41598-024-78336-z.

PMID: 39489845 Free PMC article. 

Checkpoint inhibitor-induced lichen planus differs from spontaneous lichen planus on the clinical, histological, and gene expression level. 

Meier-Schiesser B, Zecha C, Zierold S, Kolm I, Röckel M, Fröhlich W, Mittag N, Schmitt C, Kumbrink J, Hassel JC, Berking C, Nashan D, French LE, Vera-González J, Dummer R, Kerl-French K, Heinzerling L.

JAAD Int. 2024 Jan 13;15:157-164. doi: 10.1016/j.jdin.2023.11.013. eCollection 2024 Jun.

PMID: 38882039 Free PMC article. 

Machine Learning Prediction of Treatment Response to Biological Disease-Modifying Antirheumatic Drugs in Rheumatoid Arthritis. 

Salehi F, Lopera Gonzalez LI, Bayat S, Kleyer A, Zanca D, Brost A, Schett G, Eskofier BM.

J Clin Med. 2024 Jul 2;13(13):3890. doi: 10.3390/jcm13133890.

PMID: 38999454 Free PMC article. 

Discrepant Phenotyping of Monocytes Based on CX3CR1 and CCR2 Using Fluorescent Reporters and Antibodies. 

Sommer K, Garibagaoglu H, Paap EM, Wiendl M, Müller TM, Atreya I, Krönke G, Neurath MF, Zundler S.

Cells. 2024 May 10;13(10):819. doi: 10.3390/cells13100819.

PMID: 38786041 Free PMC article. 

Corrigendum to "Kidney involvement in Rosai-Dorfman disease." Kidney International 2023;103:231-232. 

Mazzariol M, Peyronel F, Fagni F, Minervini A, Santi R, Agostini S, Vaglio A.

Kidney Int. 2024 Jul;106(1):165. doi: 10.1016/j.kint.2024.04.005.

PMID: 38906650 No abstract available. 

Gene network-based and ensemble modeling-based selection of tumor-associated antigens with a predicted low risk of tissue damage for targeted immunotherapy. 

Lischer C, Eberhardt M, Flamann C, Berges J, Güse E, Wessely A, Weich A, Retzlaff J, Dörrie J, Schaft N, Wiesinger M, März J, Schuler-Thurner B, Knorr H, Gupta S, Singh KP, Schuler G, Heppt MV, Koch EAT, van Kleef ND, Freen-van Heeren JJ, Turksma AW, Wolkenhauer O, Hohberger B, Berking C, Bruns H, Vera J.

J Immunother Cancer. 2024 May 9;12(5):e008104. doi: 10.1136/jitc-2023-008104.

PMID: 38724462 Free PMC article. 

Protein Supplementation Increases Adaptations to Low-Volume, Intra-Session Concurrent Training in Untrained Healthy Adults: A Double-Blind, Placebo-Controlled, Randomized Trial. 

Reljic D, Zieseniss N, Herrmann HJ, Neurath MF, Zopf Y.

Nutrients. 2024 Aug 15;16(16):2713. doi: 10.3390/nu16162713.

PMID: 39203849 Free PMC article. Clinical Trial. 

IL-1 Inhibitors in the Treatment of Familial Mediterranean Fever: Treatment Indications and Clinical Features in a Large Real-World Cohort. 

Yalcin-Mutlu M, Icacan OC, Yildirim F, Temiz SA, Fagni F, Schett G, Tascilar K, Minopoulou I, Burul G, Bes C.

J Clin Med. 2024 Jun 7;13(12):3375. doi: 10.3390/jcm13123375.

PMID: 38929904 Free PMC article. 

Neutrophils seeking new neighbors: radiotherapy affects the cellular framework and the spatial organization in a murine breast cancer model. 

Reichardt CM, Muñoz-Becerra M, Rius Rigau A, Rückert M, Fietkau R, Schett G, Gaipl US, Frey B, Muñoz LE.

Cancer Immunol Immunother. 2024 Mar 2;73(4):67. doi: 10.1007/s00262-024-03653-1.

PMID: 38430241 Free PMC article. 

Electroporation of mRNA as a Universal Technology Platform to Transfect a Variety of Primary Cells with Antigens and Functional Proteins. 

Sauerer T, Albrecht L, Sievers NM, Gerer KF, Hoyer S, Dörrie J, Schaft N.

Methods Mol Biol. 2024;2786:219-235. doi: 10.1007/978-1-0716-3770-8_10.

PMID: 38814397 

Case report: Cerebrospinal fluid neutrophilic pleocytosis upon intrathecal triamcinolone injection. 

Tsaktanis T, Stritzelberger J, To VTD, Uhl M, Schwab S, Heuss D, Rothhammer V.

Front Neurol. 2024 Apr 23;15:1372266. doi: 10.3389/fneur.2024.1372266. eCollection 2024.

PMID: 38715689 Free PMC article. 

Hidden Appendicoliths and Their Impact on the Severity and Treatment of Acute Appendicitis. 

Dölling M, Rahimli M, Pachmann J, Szep M, Al-Madhi S, Andric M, Kahlert UD, Hofmann T, Boettcher M, Muñoz LE, Herrmann M, Perrakis A, Croner RS.

J Clin Med. 2024 Jul 16;13(14):4166. doi: 10.3390/jcm13144166.

PMID: 39064205 Free PMC article. 

CD71 expressing circulating neutrophils serve as a novel prognostic biomarker for metastatic spread and reduced outcome in pancreatic ductal adenocarcinoma patients. 

Hansen FJ, Mittelstädt A, Clausen FN, Knoedler S, Knoedler L, Klöckner S, Kuchenreuther I, Mazurie J, Arnold LS, Anthuber A, Jacobsen A, Merkel S, Weisel N, Klösch B, Karabiber A, Tacyildiz I, Czubayko F, Reitberger H, Gendy AE, Brunner M, Krautz C, Wolff K, Mihai S, Neufert C, Siebler J, Grützmann R, Weber GF, David P.

Sci Rep. 2024 Sep 10;14(1):21164. doi: 10.1038/s41598-024-70916-3.

PMID: 39256468 Free PMC article. 

Submucosal Injection of the RNA Oligonucleotide GUT-1 in Active Ulcerative Colitis Patients: A Randomized, Double-Blind, Placebo-Controlled Phase 2a Induction Trial. 

Atreya R, Kühbacher T, Waldner MJ, Hirschmann S, Drvarov O, Abu Hashem R, Maaser C, Kucharzik T, Dinter J, Mertens J, Schramm C, Holler B, Mössner J, Suzuki K, Yokoyama J, Terai S, Uter W, Yoneyama H, Asakura H, Hibi T, Neurath MF.

J Crohns Colitis. 2024 Mar 1;18(3):406-415. doi: 10.1093/ecco-jcc/jjad162.

PMID: 37777210 Clinical Trial. 

Neutrophil Depletion Changes the N-Glycosylation Pattern of IgG in Experimental Murine Sepsis. 

Yaykasli KO, van Schie KA, Toes REM, Wuhrer M, Koeleman CAM, Bila G, Negrych N, Schett G, Knopf J, Herrmann M, Bilyy R.

Int J Mol Sci. 2024 Jun 12;25(12):6478. doi: 10.3390/ijms25126478.

PMID: 38928183 Free PMC article. 

Individualized neoantigen peptide immunization of a metastatic pancreatic cancer patient: a case report of combined tumor and liquid biopsy. 

Roehnisch T, Martos-Contreras MC, Manoochehri M, Nogueira M, Bremm F, Dörrie J, Christoph J, Kunz M, Schönharting W.

Front Immunol. 2024 Jun 13;15:1414737. doi: 10.3389/fimmu.2024.1414737. eCollection 2024.

PMID: 38938562 Free PMC article. 

Tailored Bisacylphosphane Oxides for Precise Induction of Oxidative Stress-Mediated Cell Death in Biological Systems. 

Almahayni K, Salvador JB, Conti R, Widera A, Spiekermann M, Wehner D, Grützmacher H, Möckl L.

ACS Chem Biol. 2024 Nov 5. doi: 10.1021/acschembio.4c00399. Online ahead of print.

PMID: 39498831 

COVID-19 in Systemic Lupus Erythematosus patients treated with belimumab: a retrospective clinical study. 

Wu Y, Li Y, Wu T, Huang D, Wu J, Zhang W, Jiang X, Yao C, Liang X, Cheng L, Liao Z, Xu F, Tan C, Liu Y, Herrmann M.

Immunol Res. 2024 Jun;72(3):418-429. doi: 10.1007/s12026-023-09449-2. Epub 2023 Dec 22.

PMID: 38133855 

Protocol for mapping the heterogeneous dendritic cell network across the murine tissue landscape via high-dimensional flow cytometry. 

Amon L, Seichter A, Vurnek D, Tchitashvili G, Heß I, Heger L, Lehmann CHK, Dudziak D.

STAR Protoc. 2024 Sep 20;5(3):103151. doi: 10.1016/j.xpro.2024.103151. Epub 2024 Jul 9.

PMID: 38990726 Free PMC article. 

Intra-arterial delivery of neurospheres into isolated perfused porcine colons: a proof of concept. 

Martel RD, Hoyos NA, Tapia-Laliena MÁ, Herrmann I, Herrmann M, Khasanov R, Schäfer KH.

Biol Methods Protoc. 2024 Apr 2;9(1):bpae022. doi: 10.1093/biomethods/bpae022. eCollection 2024.

PMID: 38628556 Free PMC article. 

Intravenous Immunoglobulin Therapy for Pyoderma Gangrenosum: A Multicenter Retrospective Analysis in 81 Patients. 

Ronicke M, Sollfrank L, Vitus MV, Walter LJ, Krieter M, Moelleken M, Dissemond J, Schultz E, Lauffer F, von den Driesch P, Erfurt-Berge C.

Am J Clin Dermatol. 2024 Nov 14. doi: 10.1007/s40257-024-00904-w. Online ahead of print.

PMID: 39541069 

Elevated aluminum excretion in patients by long-term subcutaneous immunotherapy - A cross-sectional case-control study. 

Hiller J, Göen T, Drexler H, Berking C, Wagner N.

Int J Hyg Environ Health. 2024 May;258:114337. doi: 10.1016/j.ijheh.2024.114337. Epub 2024 Mar 10.

PMID: 38461738 

Interdependence of coagulation with immunotherapy and BRAF/MEK inhibitor therapy: results from a prospective study. 

Beckmann M, Schlüter J, Erdmann M, Kramer R, Cunningham S, Hackstein H, Zimmermann R, Heinzerling L.

Cancer Immunol Immunother. 2024 Nov 2;74(1):5. doi: 10.1007/s00262-024-03850-y.

PMID: 39487855 Free PMC article. 

Prognostic relevance of ARFI elastography in comparison to liver histology and the FIB-4 score. 

Klüppel M, Adler W, Schellhaas B, Jesper D, Neurath MF, Pfeifer L.

Ultraschall Med. 2024 Jun;45(3):316-322. doi: 10.1055/a-2178-4808. Epub 2024 Jan 3.

PMID: 38171381 English. 

Interferential Current Stimulation of Rectal Motor Activity - Objective Data from the Isolated Perfused Porcine Rectum. 

Martel R, Boettcher M, Klinke M, Hoyos NA, Herrmann I, Magerl W, Herrmann M.

Eur J Pediatr Surg. 2024 Nov 25. doi: 10.1055/a-2482-5997. Online ahead of print.

PMID: 39587047 

Brief Communication: Treatment Outcomes for Advanced Melanoma of Unknown Primary Compared With Melanoma With Known Primary. 

Persa OD, Hassel JC, Steeb T, Erdmann M, Karimi B, Stege H, Klespe KC, Schatton K, Tomsitz D, Rübben A, Thiem A, Berking C, Biedermann T.

J Immunother. 2024 Nov-Dec 01;47(9):384-387. doi: 10.1097/CJI.0000000000000537. Epub 2024 Aug 29.

PMID: 39206786 

Neutrophil-to-Lymphocyte Ratio as a Biomarker for Clinical Response After Autologous Hematopoietic Stem Cell Transplantation in Systemic Sclerosis. 

Keret S, Kaly L, Schett G, Bergmann C, Feldman E, Zuckerman T, Yehudai-Ofir D, Shouval A, Awisat A, Rosner I, Rozenbaum M, Boulman N, Sawaed A, Hardak E, Henes J, Slobodin G, Rimar D.

Rheumatology (Oxford). 2024 Nov 1:keae606. doi: 10.1093/rheumatology/keae606. Online ahead of print.

PMID: 39485492 

"The Simpler, the Better." A Qualitative Study on Digital Health Transformation in Early Adopter Rheumatology Outpatient Clinics. 

May S, Darkow R, Knitza J, Boy K, Schwarz J, Heinze M, Hornig J, Aries P, Welcker M, Muehlensiepen F.

Inquiry. 2024 Jan-Dec;61:469580241247021. doi: 10.1177/00469580241247021.

PMID: 38801153 Free PMC article. 

Inflammatory Signals Across the Spectrum: A Detailed Exploration of Acute Appendicitis Stages According to EAES 2015 Guidelines. 

Dölling M, Andric M, Rahimli M, Klös M, Pachmann J, Stockheim J, Al-Madhi S, Wex C, Kahlert UD, Herrmann M, Perrakis A, Croner RS.

Diagnostics (Basel). 2024 Oct 21;14(20):2335. doi: 10.3390/diagnostics14202335.

PMID: 39451658 Free PMC article. 

Competencies for health-enhancing physical activity are associated with body mass: results of an updated data pooling across 18 samples. 

Carl J, Zheng M, Popp J, Eckert K, Geidl W, Blaschke S, Schmid J, Grüne E, Oppermann L, Liphardt AM, Morf H, Weissenfels A, Pfeifer K.

Obesity (Silver Spring). 2024 Nov;32(11):2161-2174. doi: 10.1002/oby.24121. Epub 2024 Sep 24.

PMID: 39318026 

German Version of the Telehealth Usability Questionnaire and Derived Short Questionnaires for Usability and Perceived Usefulness in Health Care Assessment in Telehealth and Digital Therapeutics: Instrument Validation Study. 

Zimmermann J, Morf H, Scharf F, Knitza J, Moeller H, Muehlensiepen F, Nathrath M, Orlemann T, Voelker T, Deckers M.

JMIR Hum Factors. 2024 Nov 21;11:e57771. doi: 10.2196/57771.

PMID: 39571151 

Clinical Pharmacist Counselling Improves Long-term Medication Safety and Patient-reported Outcomes in Anti-TNF-treated Patients With Inflammatory Bowel Diseases: The Prospective, Randomized AdPhaNCED Trial. 

Plechschmidt J, Fietkau K, Hepp T, Dietrich P, Fischer S, Krebs S, Neurath MF, Dörje F, Atreya R.

Inflamm Bowel Dis. 2024 Mar 20:izae040. doi: 10.1093/ibd/izae040. Online ahead of print.

PMID: 38507608 

The Immune Checkpoint BTLA in Oral Cancer: Expression Analysis and Its Correlation to Other Immune Modulators. 

Ries J, Trumet L, Hahn A, Kunater L, Lutz R, Geppert C, Kesting M, Weber M.

Int J Mol Sci. 2024 Jun 15;25(12):6601. doi: 10.3390/ijms25126601.

PMID: 38928307 Free PMC article. 

Comparative Analysis of Inhibitory and Activating Immune Checkpoints PD-1, PD-L1, CD28, and CD86 in Non-Melanoma Skin Cancer. 

Winter L, Ries J, Vogl C, Trumet L, Geppert CI, Lutz R, Kesting M, Weber M.

Cells. 2024 Sep 18;13(18):1569. doi: 10.3390/cells13181569.

PMID: 39329753 Free PMC article. 

Spatial cell graph analysis reveals skin tissue organization characteristic for cutaneous T cell lymphoma. 

Sarkar S, Möller A, Hartebrodt A, Erdmann M, Ostalecki C, Baur A, Blumenthal DB.

NPJ Syst Biol Appl. 2024 Dec 2;10(1):143. doi: 10.1038/s41540-024-00474-x.

PMID: 39622929